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The map label for this gene is fabG [C]

Identifier: 41409665

GI number: 41409665

Start: 3967125

End: 3967988

Strand: Direct

Name: fabG [C]

Synonym: MAP3567

Alternate gene names: 41409665

Gene position: 3967125-3967988 (Clockwise)

Preceding gene: 41409664

Following gene: 41409669

Centisome position: 82.14

GC content: 67.82

Gene sequence:

>864_bases
ATGCCCGGAGTGCAGGATCGCGTCATCGTCGTCACCGGAGCCGGTGGCGGGCTGGGCCGTGAGTACGCCCTGACGCTGGC
CCGCGAGGGTGCCAGCGTGGTCGTCAACGACCTCGGCGGGGCCCGCGACGGCACCGGCGCCGGCCACAACATGGCCGACC
AGGTGGTCAAGGAGATCAAGGACGCCGGCGGCCGCGCGGTGGCCAACTACGACAGCGTGGCCGAGCCCGCGGGCGCTGAG
AACATCATCAAAACCGCGCTTGATGAGTTCGGCGCCGTGCACGGCGTGGTGAGCAACGCCGGGATCCTGCGCGACGGCAC
CTTCCACAAGATGTTGTTCGAGAACTGGGACGCCGTGCTCAAGGTGCACCTGTACGGCGGGTACAACGTGATCCGCGCCG
CCTGGCCGCACTTCCGCGAGCAGAGCTACGGCCGGGTCGTCGTCGCCACCTCCACCAGCGGCCTGTTCGGCAACTTCGGC
CAAACCAATTACGGGGCAGCCAAACTCGGCCTGGTTGGCCTGATCAACAGCCTGGCGCTGGAGGGGGCCAAGTACAACAT
CCACGCCAACGCGATCGCCCCGATCGCGGCGACCCGGATGACCGAGGACATCCTGCCCAAGGAAGTGCTGGCCAAGCTGA
CCCCCGAGTACGTCGCGCCGGTGGTCGCCTACCTGTGCACTGAGGAAAACCCCAACAGCGCTTCGGTTTTCGTGGTCGGT
GGCGGCAAGGTGCAGCGCGTCGCGCTGTTCCAGAACGCCGGCGTCACCTACGACAAGCCGCCGACGGTGCAGGACGTCGC
CGCGCGGTGGGACGAGATCACCGACCTGTCCGCGGCCAAGCAGGCCGACTTCAAGCTGGGGTAG

Upstream 100 bases:

>100_bases
TACACGGAGCGGGCCTTCAAGATGGCCCGCAAGATGTTCTGACCGCTGGCTTCACCGAATCGGTTGCCAGACAGAGCTTT
TCACAGCAGAGAGGAATCTT

Downstream 100 bases:

>100_bases
GCAGCGGGCGGTCGGCGGGTCAGGCGAGCAGCGCCGCGCGCAGGCGTTGCACGTCTGCCTCGCCGACCCCGGCGTCGCGC
AGGTAGGCCTGCAGCGACCC

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVKEIKDAGGRAVANYDSVAEPAGAE
NIIKTALDEFGAVHGVVSNAGILRDGTFHKMLFENWDAVLKVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSGLFGNFG
QTNYGAAKLGLVGLINSLALEGAKYNIHANAIAPIAATRMTEDILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVG
GGKVQRVALFQNAGVTYDKPPTVQDVAARWDEITDLSAAKQADFKLG

Sequences:

>Translated_287_residues
MPGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVKEIKDAGGRAVANYDSVAEPAGAE
NIIKTALDEFGAVHGVVSNAGILRDGTFHKMLFENWDAVLKVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSGLFGNFG
QTNYGAAKLGLVGLINSLALEGAKYNIHANAIAPIAATRMTEDILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVG
GGKVQRVALFQNAGVTYDKPPTVQDVAARWDEITDLSAAKQADFKLG
>Mature_286_residues
PGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVKEIKDAGGRAVANYDSVAEPAGAEN
IIKTALDEFGAVHGVVSNAGILRDGTFHKMLFENWDAVLKVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSGLFGNFGQ
TNYGAAKLGLVGLINSLALEGAKYNIHANAIAPIAATRMTEDILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVGG
GKVQRVALFQNAGVTYDKPPTVQDVAARWDEITDLSAAKQADFKLG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=278, Percent_Identity=50.7194244604317, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=33.4645669291339, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=32.9268292682927, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=27.734375, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503817, Length=244, Percent_Identity=25.4098360655738, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI25282469, Length=246, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=235, Percent_Identity=32.3404255319149, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=240, Percent_Identity=29.5833333333333, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=212, Percent_Identity=27.8301886792453, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789208, Length=209, Percent_Identity=28.2296650717703, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=25.6916996047431, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=28.1746031746032, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787526, Length=230, Percent_Identity=28.695652173913, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786812, Length=184, Percent_Identity=28.2608695652174, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789057, Length=208, Percent_Identity=30.2884615384615, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=26.0416666666667, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=274, Percent_Identity=49.6350364963504, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI25147288, Length=239, Percent_Identity=34.7280334728033, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=28.2945736434109, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=258, Percent_Identity=27.1317829457364, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=222, Percent_Identity=30.6306306306306, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=26.615969581749, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=239, Percent_Identity=28.4518828451883, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=29.9465240641711, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=281, Percent_Identity=51.6014234875445, Blast_Score=275, Evalue=5e-75,
Organism=Drosophila melanogaster, GI18859837, Length=279, Percent_Identity=47.6702508960573, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=29.9212598425197, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=30.8900523560209, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356301, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=26.7676767676768, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364892, Length=179, Percent_Identity=26.2569832402235, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737361, Length=228, Percent_Identity=28.5087719298246, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=25.6544502617801, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28571526, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30184; Mature: 30053

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVKEIK
CCCCCCCEEEEECCCCCCCHHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
DAGGRAVANYDSVAEPAGAENIIKTALDEFGAVHGVVSNAGILRDGTFHKMLFENWDAVL
HCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCEEE
KVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSGLFGNFGQTNYGAAKLGLVGLINSLAL
EEEEECCCHHHHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGAKYNIHANAIAPIAATRMTEDILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVG
CCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEE
GGKVQRVALFQNAGVTYDKPPTVQDVAARWDEITDLSAAKQADFKLG
CCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PGVQDRVIVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVKEIK
CCCCCCEEEEECCCCCCCHHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
DAGGRAVANYDSVAEPAGAENIIKTALDEFGAVHGVVSNAGILRDGTFHKMLFENWDAVL
HCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCEEE
KVHLYGGYNVIRAAWPHFREQSYGRVVVATSTSGLFGNFGQTNYGAAKLGLVGLINSLAL
EEEEECCCHHHHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGAKYNIHANAIAPIAATRMTEDILPKEVLAKLTPEYVAPVVAYLCTEENPNSASVFVVG
CCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEE
GGKVQRVALFQNAGVTYDKPPTVQDVAARWDEITDLSAAKQADFKLG
CCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]