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The map label for this gene is fgd1 [H]

Identifier: 41409639

GI number: 41409639

Start: 3943792

End: 3944922

Strand: Reverse

Name: fgd1 [H]

Synonym: MAP3541c

Alternate gene names: 41409639

Gene position: 3944922-3943792 (Counterclockwise)

Preceding gene: 41409642

Following gene: 41409638

Centisome position: 81.68

GC content: 69.85

Gene sequence:

>1131_bases
GTGTGTGTGAGGCCGGCGGTGGCGGGTATGCCGACGGGGGTGACCGGCATTTCGCGGCGAACGTTGGGGCGGCTGGCGGT
CGGTGCCGGCGTGCTCGCGTCCGCGGTCCAGGCATGCGCGAAGCCGGGCGCCGGGCACGGCCGATCCGGCGCACCGCCGG
CGCCCGCGGGCAAGGGCGTCGGGTTTGTGCTCTCCCACGAGCAGTTCCGCACCGACCGGTTGGTGGCACAGGCGCAGGCG
GCCGAACGGGCCGGCTTCACCCACGTGTGGGCCAGCGATCACATCCAGCCGTGGCAGGACAACGAGGGCCATTCGATGTT
TCCGTGGCTGACGCTGGCGTTGGTGGGCAGCAGCACCAGCCACGTCTCGTTCGGCACCGGGGTGACCTGTCCGACCTACC
GCTATCACCCCGCCACGGTGGCCCAGGCGTTCGCCTCGCTGGCAATCCTCAACCCCGGCAGGGTGTTTCTGGGAGTGGGC
ACCGGCGAGCGGCTCAACGAGCAGGCCACCACCAACGGCTACGGCAACTACACCGAACGCCACGAACGGCTGGCCGAGGC
GATCGCGCTGATCCGCCAGCTGTGGAGCGGGTCGCGAATCTCGTTCTCCGGCCGCTACTTTCAGACGAATTCACTAAAGC
TGTACGACGTGCCGGCCACCCCGCCGCCGATCTTCGTGGCGGCTGGCGGCCCGAAGAGCGCGAAGCTGGCCGGGCAGTTC
GGCGACGGCTGGATCACCCAGTCCGGCGACGTCACCAATCCAAAACTGTTGGCGGCCTTCGGTGCTGGAGCCCAAGCGGC
CGGGCGTGACGTAGCGACCCTGGGGAAACGGGCCGAGATGTTCGCCGTCGTCGGCGATGACGCCGTGGCCGCCCGCGCGG
CCACGCTGTGGCGCTTCACGGCCGGCGCGGTCGACCAGCCGGATCCGGTGGACATCCAGCGGGCCGCCGAGTCCAATCCC
ACCGACAAGGTGTTGGGTGGCTGGACGGTCGGCACCGACGCGGGTCGGCACGTCGAGGCCGCGCAGCGGGTCCTGGACGC
GGGCGCCGTTCCCTTCCTGCACTTTCCGCAGGACGACCCGATGGTCGCCATCGACTTCTACCGGGACAATGTCTTACCGA
AATTGCGCTGA

Upstream 100 bases:

>100_bases
CGTAGAACGCGCGGGCCAGCGTGGCCGACAGTGCGCGGATGTCGGCCCGGTCGGCCGGGCGGACCTGCGGGGTCATCCAC
CCGAGGCTAGTGCGTACCCG

Downstream 100 bases:

>100_bases
ACCCGCTTAGGGCAACGCCGGTTTCGCCGCTGCCGGCCACAAACTCGCGGCGGATCGGGCAGAATCGGGACGTTATGGAT
GCAGTGGACCCGGATTCCCG

Product: hypothetical protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MCVRPAVAGMPTGVTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFVLSHEQFRTDRLVAQAQA
AERAGFTHVWASDHIQPWQDNEGHSMFPWLTLALVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVG
TGERLNEQATTNGYGNYTERHERLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPPIFVAAGGPKSAKLAGQF
GDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFTAGAVDQPDPVDIQRAAESNP
TDKVLGGWTVGTDAGRHVEAAQRVLDAGAVPFLHFPQDDPMVAIDFYRDNVLPKLR

Sequences:

>Translated_376_residues
MCVRPAVAGMPTGVTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFVLSHEQFRTDRLVAQAQA
AERAGFTHVWASDHIQPWQDNEGHSMFPWLTLALVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVG
TGERLNEQATTNGYGNYTERHERLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPPIFVAAGGPKSAKLAGQF
GDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFTAGAVDQPDPVDIQRAAESNP
TDKVLGGWTVGTDAGRHVEAAQRVLDAGAVPFLHFPQDDPMVAIDFYRDNVLPKLR
>Mature_376_residues
MCVRPAVAGMPTGVTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFVLSHEQFRTDRLVAQAQA
AERAGFTHVWASDHIQPWQDNEGHSMFPWLTLALVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVG
TGERLNEQATTNGYGNYTERHERLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPPIFVAAGGPKSAKLAGQF
GDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFTAGAVDQPDPVDIQRAAESNP
TDKVLGGWTVGTDAGRHVEAAQRVLDAGAVPFLHFPQDDPMVAIDFYRDNVLPKLR

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 39550; Mature: 39550

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVRPAVAGMPTGVTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GFVLSHEQFRTDRLVAQAQAAERAGFTHVWASDHIQPWQDNEGHSMFPWLTLALVGSSTS
EEEEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEHHHHEEHHHCCCCC
HVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVGTGERLNEQATTNGYGNYTER
CEECCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEEEECCCCCHHCCHHCCCCCCCHHHH
HERLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPPIFVAAGGPKSAKLAGQF
HHHHHHHHHHHHHHHCCCEEEECCCEEEECCEEEEECCCCCCCEEEECCCCCCCEEECCC
GDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFT
CCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
AGAVDQPDPVDIQRAAESNPTDKVLGGWTVGTDAGRHVEAAQRVLDAGAVPFLHFPQDDP
CCCCCCCCCCHHHHHHCCCCCCCEECCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCC
MVAIDFYRDNVLPKLR
EEEEEEECCCCCCCCC
>Mature Secondary Structure
MCVRPAVAGMPTGVTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GFVLSHEQFRTDRLVAQAQAAERAGFTHVWASDHIQPWQDNEGHSMFPWLTLALVGSSTS
EEEEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEHHHHEEHHHCCCCC
HVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVGTGERLNEQATTNGYGNYTER
CEECCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEEEECCCCCHHCCHHCCCCCCCHHHH
HERLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPPIFVAAGGPKSAKLAGQF
HHHHHHHHHHHHHHHCCCEEEECCCEEEECCEEEEECCCCCCCEEEECCCCCCCEEECCC
GDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFT
CCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
AGAVDQPDPVDIQRAAESNPTDKVLGGWTVGTDAGRHVEAAQRVLDAGAVPFLHFPQDDP
CCCCCCCCCCHHHHHHCCCCCCCEECCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCC
MVAIDFYRDNVLPKLR
EEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]