The gene/protein map for NC_002944 is currently unavailable.
Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is xecD [H]

Identifier: 41409601

GI number: 41409601

Start: 3899022

End: 3899804

Strand: Reverse

Name: xecD [H]

Synonym: MAP3503c

Alternate gene names: 41409601

Gene position: 3899804-3899022 (Counterclockwise)

Preceding gene: 41409602

Following gene: 41409598

Centisome position: 80.74

GC content: 68.45

Gene sequence:

>783_bases
ATGGCTGACATGCAGGTCGCGATCGTCACGGGCGCAAGCAGCGGCATCGGGTTGGGCTGCGCGACCAGGCTGGCCGGGAC
GGGCATGGCGGTGCTCGGCACCGGCCGCGACCCAAAGCGGTTGGCCGAGTTGGAAACCGCGATCGGCGACCCCGACCGGG
TCGCCACCGTCGCGGTCGACCTGACCGACGACGACGCGCCGCGGCGCATCGTGGACCGCGCCCTGCAGCGGTGGGGCCAC
ATCGACTTCCTGATCAACAACGCCGGCGTGGGCAGCCCCAAACCGCTGCACGAAACCGACGACGACACCCTGGACTACTT
CCTGAATTTGATGCTGCGGGCACCGTTTCGGCTCGCGCGCGAGGTGCTGCCCCACCTGCCGCCCGGATCGGCGATCATCA
ACGTGACATCGACGTTCGCCGTCGTCGGCGGCCTGCGCGGCGGCGCCTACTCCGCGGCCAAGGGCGGGCTGACCGCGCTG
ACCACCCACATCGCCTGCCAATACGGCGCCTCCGGCATCCGCTGCAATGCCGTCGCGCCGGGGGTGACGGTCACCCCGAT
GGTGGAAAAGCGGTTGCAGGACCCGCGCTTTCGCAAGATCAACACGGAGATGACACCGCACCAACGGTTGGGCAGCGTCG
ACGACATCGCCGCCACCGTCGCGTTCCTGTGCTCGCCGGGCGGAAGTTTCATCAACGGCCAGACGATCGTGGTCGACGGC
GGATGGAGTTCGACGAAGTATCTGTCGGAGTACGCGCTGACCTCGGAGTGGATCGCGCCGTGA

Upstream 100 bases:

>100_bases
AAGTTCAAGGCGCCCGAACAAGTGGTGCTCTGGGATGCCCTGCCGAAGAACGACGCCGGCAAGGTGCTCAAGCATCGGAT
CCGCGCGGCGCTGAGTAAGG

Downstream 100 bases:

>100_bases
GTTAGCGGCTACCGGCTGGCGAAGTCGATGACGCCGCGGATGTTGCGGCCCTCGCGCAGGTCGGCGAATGCCTCGTTGAT
CTCGTCGAGCCGGTAGTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: R-HPCDH; Aliphatic epoxide carboxylation component III [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MADMQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRLAELETAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWGH
IDFLINNAGVGSPKPLHETDDDTLDYFLNLMLRAPFRLAREVLPHLPPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTAL
TTHIACQYGASGIRCNAVAPGVTVTPMVEKRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFINGQTIVVDG
GWSSTKYLSEYALTSEWIAP

Sequences:

>Translated_260_residues
MADMQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRLAELETAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWGH
IDFLINNAGVGSPKPLHETDDDTLDYFLNLMLRAPFRLAREVLPHLPPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTAL
TTHIACQYGASGIRCNAVAPGVTVTPMVEKRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFINGQTIVVDG
GWSSTKYLSEYALTSEWIAP
>Mature_259_residues
ADMQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRLAELETAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWGHI
DFLINNAGVGSPKPLHETDDDTLDYFLNLMLRAPFRLAREVLPHLPPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALT
THIACQYGASGIRCNAVAPGVTVTPMVEKRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFINGQTIVVDGG
WSSTKYLSEYALTSEWIAP

Specific function: Catalyzes the oxidation of 2-(R)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the R enantiomers [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=31.8367346938775, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=31.7991631799163, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923817, Length=248, Percent_Identity=29.4354838709677, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI15277342, Length=248, Percent_Identity=31.4516129032258, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=28.4, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=30.3643724696356, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4503301, Length=195, Percent_Identity=29.2307692307692, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI59889578, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=28.6885245901639, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=31.0526315789474, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723750, Length=244, Percent_Identity=26.6393442622951, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=187, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=27.734375, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789208, Length=242, Percent_Identity=32.2314049586777, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=30.1652892561983, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=30, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=30.078125, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=31.2757201646091, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=31.2757201646091, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790717, Length=238, Percent_Identity=27.3109243697479, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=26.9076305220884, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=26.1111111111111, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=27.5720164609054, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=35.2226720647773, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=35.8267716535433, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=31.5384615384615, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=31.9230769230769, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=32.5670498084291, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI72000259, Length=257, Percent_Identity=33.0739299610895, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=29.6296296296296, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=32.5581395348837, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=31.4176245210728, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=31.203007518797, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=29.3893129770992, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=31.5384615384615, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=255, Percent_Identity=30.9803921568627, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=253, Percent_Identity=31.6205533596838, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=30.8880308880309, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=32.8185328185328, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=258, Percent_Identity=29.0697674418605, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=30.0813008130081, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=32.1705426356589, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=243, Percent_Identity=27.9835390946502, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=29.2134831460674, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=29.6153846153846, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=26.7489711934156, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=253, Percent_Identity=30.0395256916996, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=253, Percent_Identity=28.0632411067194, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=26.2948207171315, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=26, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=30.078125, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=25.668449197861, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=32.2175732217573, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=35.4838709677419, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=33.4677419354839, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=34, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=33.0677290836653, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=28.7449392712551, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=29.2181069958848, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18859837, Length=260, Percent_Identity=24.6153846153846, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24663911, Length=219, Percent_Identity=26.027397260274, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.268 [H]

Molecular weight: Translated: 27431; Mature: 27299

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MADMQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRLAELETAIGDPDRVATVAVD
CCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEE
LTDDDAPRRIVDRALQRWGHIDFLINNAGVGSPKPLHETDDDTLDYFLNLMLRAPFRLAR
ECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
EVLPHLPPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGASGIRCNAVAP
HHHCCCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEECCCC
GVTVTPMVEKRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFINGQTIVVDG
CCEECHHHHHHCCCCCCEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEECCCEEEEEC
GWSSTKYLSEYALTSEWIAP
CCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADMQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRLAELETAIGDPDRVATVAVD
CCEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEE
LTDDDAPRRIVDRALQRWGHIDFLINNAGVGSPKPLHETDDDTLDYFLNLMLRAPFRLAR
ECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
EVLPHLPPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGASGIRCNAVAP
HHHCCCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEECCCC
GVTVTPMVEKRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFINGQTIVVDG
CCEECHHHHHHCCCCCCEECCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEECCCEEEEEC
GWSSTKYLSEYALTSEWIAP
CCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704278; 9405410; 12524213 [H]