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The map label for this gene is fadK [H]

Identifier: 41409602

GI number: 41409602

Start: 3899797

End: 3901350

Strand: Reverse

Name: fadK [H]

Synonym: MAP3504c

Alternate gene names: 41409602

Gene position: 3901350-3899797 (Counterclockwise)

Preceding gene: 41409603

Following gene: 41409601

Centisome position: 80.78

GC content: 70.59

Gene sequence:

>1554_bases
GTGCGTAGCACACTGGCCGACGCGGCGCGCGCCGCTGCGCAACGTACGCCCGAGCGGATAGCGTTGGTGGACAACGAGGT
TCGGCTGAACTGCGCCACCCTGTACGCCCAGGCCGGCGAGCTGGCCGCCGCCCTGCTGGCCCGTATCCCGGCCGGCAGCG
TGGTGTCGTTCATGCTGCCGAACTGGCACGAGGCCGCGGTCATCTACCTGGCCGCGACACTGGCCGGCATGGTGGTGAAC
CCGATCCTGCCGTCGCTGCGCGACCACGACCTGCGTTTCATCCTCGAGGATGCCTGCGCTGCAATGGTTTTCGTCCCGCA
CCGGTACGGCGGCCACGACTACCCGGCGATGCTGGACCGCGTGACGGCCGCGATGAGTGCGGCGCCGCAGGTGGTGGTGC
TGCGCGGCCCCGCAACGGGACGAACCGGTCGGCACACCCCGTACCGCTGCATGCTGGGCGGACCGCCCGGGGGTCTTCCG
GCCCTGGATCCCGATGCGGTGCGGATGATCCTCTATACCTCCGGCACCACCAGCCGCCCGAAAGGTGTTCTGCACACCCA
TAATTCGATACATGCGCTGATCTGCCAGATCCGTGACCACTGGGCGATCGATCCCGGCGACACATTCCTGGTGCCGTCGC
CGCTCGCCCATATCGGCGGCTCGATCTACGCGTTTGAATGCCCGCTGCTGCTGGGCACCACGGCGGTGCTGATGGACCGG
TGGGACCCGGCGCGGGCGGTGGCGTTGATGACCGCGCATCGCTGCACCCACATGGCCGGGGCCACACCGTTTTTGCAGCA
GCTGCTCTCGGCCGCCGCGAACGCCCGCACCCGCCTGCCCGACCTGAAGGTGTTCATCTGCGGCGGCGCCTCGGTGTCGC
CGTCACTGATCCGCCGGGCCGCGGCCTATTTCGACCGCGCGGTCGTCACCCGGGTGTACGGCTGCACCGAGGTGCCGGTG
GCCACCGTCGGGGCTCCCCGACCGCAGGAGGCCGACTACGCCGCCGATACCGACGGCCGGCCCGGCATCGCCGAGATCAA
GCTCGCCGCGCACCCGGCGGCGCCCACCGGTGACGGCGAGATCTGCGTGCGCGGCCCGCAGATGCTGCGCGGCTACCGCC
ACCCGGAGGACGACGCCGAGTCCTTCGACGCCGCAGGGTTTTTCCGCACCGGCGACCTGGGCCGCTGGGCGTTAGCCGAT
TCCGCCGGCCGGTACCTGGTCGTGACCGGCCGCGCCAAGGACGTCATCATCCGCAGCGGCGAGAACATCTCCGCCAAGGA
GGTGGAGGACCTGCTGGCCGACCATCCCGGCATCGCCGAGATCGCGGTCGTCGGGCTGCCCGACGAGCGCACCGGCGAGC
GGGCGTGCGCGGTCATCGTTCCCACCCCCGGGGCGAGCCCGGACGTGGCCGGCCTGCTGGCGCTGCTGGTGAGCAAGGGG
GTGGCCAAGTTCAAGGCGCCCGAACAAGTGGTGCTCTGGGATGCCCTGCCGAAGAACGACGCCGGCAAGGTGCTCAAGCA
TCGGATCCGCGCGGCGCTGAGTAAGGATGGCTGA

Upstream 100 bases:

>100_bases
ATGACGATGCGCCGCGTCACCGGTCAGGCCGGTTGAGATGACCGCCCGCACCGCCCCGGACGCCGCGCAAACATCGCTGG
CCTACCGGCGCGGCTGGTGG

Downstream 100 bases:

>100_bases
CATGCAGGTCGCGATCGTCACGGGCGCAAGCAGCGGCATCGGGTTGGGCTGCGCGACCAGGCTGGCCGGGACGGGCATGG
CGGTGCTCGGCACCGGCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MRSTLADAARAAAQRTPERIALVDNEVRLNCATLYAQAGELAAALLARIPAGSVVSFMLPNWHEAAVIYLAATLAGMVVN
PILPSLRDHDLRFILEDACAAMVFVPHRYGGHDYPAMLDRVTAAMSAAPQVVVLRGPATGRTGRHTPYRCMLGGPPGGLP
ALDPDAVRMILYTSGTTSRPKGVLHTHNSIHALICQIRDHWAIDPGDTFLVPSPLAHIGGSIYAFECPLLLGTTAVLMDR
WDPARAVALMTAHRCTHMAGATPFLQQLLSAAANARTRLPDLKVFICGGASVSPSLIRRAAAYFDRAVVTRVYGCTEVPV
ATVGAPRPQEADYAADTDGRPGIAEIKLAAHPAAPTGDGEICVRGPQMLRGYRHPEDDAESFDAAGFFRTGDLGRWALAD
SAGRYLVVTGRAKDVIIRSGENISAKEVEDLLADHPGIAEIAVVGLPDERTGERACAVIVPTPGASPDVAGLLALLVSKG
VAKFKAPEQVVLWDALPKNDAGKVLKHRIRAALSKDG

Sequences:

>Translated_517_residues
MRSTLADAARAAAQRTPERIALVDNEVRLNCATLYAQAGELAAALLARIPAGSVVSFMLPNWHEAAVIYLAATLAGMVVN
PILPSLRDHDLRFILEDACAAMVFVPHRYGGHDYPAMLDRVTAAMSAAPQVVVLRGPATGRTGRHTPYRCMLGGPPGGLP
ALDPDAVRMILYTSGTTSRPKGVLHTHNSIHALICQIRDHWAIDPGDTFLVPSPLAHIGGSIYAFECPLLLGTTAVLMDR
WDPARAVALMTAHRCTHMAGATPFLQQLLSAAANARTRLPDLKVFICGGASVSPSLIRRAAAYFDRAVVTRVYGCTEVPV
ATVGAPRPQEADYAADTDGRPGIAEIKLAAHPAAPTGDGEICVRGPQMLRGYRHPEDDAESFDAAGFFRTGDLGRWALAD
SAGRYLVVTGRAKDVIIRSGENISAKEVEDLLADHPGIAEIAVVGLPDERTGERACAVIVPTPGASPDVAGLLALLVSKG
VAKFKAPEQVVLWDALPKNDAGKVLKHRIRAALSKDG
>Mature_517_residues
MRSTLADAARAAAQRTPERIALVDNEVRLNCATLYAQAGELAAALLARIPAGSVVSFMLPNWHEAAVIYLAATLAGMVVN
PILPSLRDHDLRFILEDACAAMVFVPHRYGGHDYPAMLDRVTAAMSAAPQVVVLRGPATGRTGRHTPYRCMLGGPPGGLP
ALDPDAVRMILYTSGTTSRPKGVLHTHNSIHALICQIRDHWAIDPGDTFLVPSPLAHIGGSIYAFECPLLLGTTAVLMDR
WDPARAVALMTAHRCTHMAGATPFLQQLLSAAANARTRLPDLKVFICGGASVSPSLIRRAAAYFDRAVVTRVYGCTEVPV
ATVGAPRPQEADYAADTDGRPGIAEIKLAAHPAAPTGDGEICVRGPQMLRGYRHPEDDAESFDAAGFFRTGDLGRWALAD
SAGRYLVVTGRAKDVIIRSGENISAKEVEDLLADHPGIAEIAVVGLPDERTGERACAVIVPTPGASPDVAGLLALLVSKG
VAKFKAPEQVVLWDALPKNDAGKVLKHRIRAALSKDG

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is ma

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein. Note=Partially membrane-associated [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=555, Percent_Identity=26.4864864864865, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI187761345, Length=544, Percent_Identity=26.4705882352941, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI187761343, Length=544, Percent_Identity=26.4705882352941, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI28416953, Length=376, Percent_Identity=28.9893617021277, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI42544132, Length=381, Percent_Identity=26.246719160105, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI115511026, Length=373, Percent_Identity=25.201072386059, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI38505220, Length=523, Percent_Identity=23.9005736137667, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI157311624, Length=482, Percent_Identity=23.8589211618257, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI157311622, Length=482, Percent_Identity=23.8589211618257, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI58082049, Length=356, Percent_Identity=25.8426966292135, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI122937307, Length=356, Percent_Identity=26.685393258427, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=34.8571428571429, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1788107, Length=546, Percent_Identity=25.0915750915751, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=27.7246653919694, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI221142682, Length=482, Percent_Identity=25.7261410788382, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790505, Length=506, Percent_Identity=24.5059288537549, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789201, Length=283, Percent_Identity=28.2685512367491, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786801, Length=503, Percent_Identity=24.0556660039761, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788595, Length=512, Percent_Identity=25.1953125, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786529, Length=551, Percent_Identity=24.5009074410163, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=509, Percent_Identity=25.9332023575639, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=515, Percent_Identity=25.8252427184466, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17538037, Length=540, Percent_Identity=25.1851851851852, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=534, Percent_Identity=25.6554307116105, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71994703, Length=550, Percent_Identity=24.5454545454545, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=550, Percent_Identity=24.5454545454545, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71994690, Length=550, Percent_Identity=24.5454545454545, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560308, Length=563, Percent_Identity=24.1563055062167, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17560140, Length=524, Percent_Identity=25.763358778626, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=507, Percent_Identity=23.8658777120316, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559526, Length=490, Percent_Identity=25.1020408163265, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=360, Percent_Identity=27.5, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17531443, Length=479, Percent_Identity=22.3382045929019, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25141359, Length=452, Percent_Identity=21.2389380530973, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=480, Percent_Identity=25.8333333333333, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319264, Length=517, Percent_Identity=24.3713733075435, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323182, Length=566, Percent_Identity=24.0282685512367, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581924, Length=360, Percent_Identity=30.5555555555556, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI18859661, Length=362, Percent_Identity=28.7292817679558, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19922652, Length=505, Percent_Identity=23.1683168316832, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653035, Length=463, Percent_Identity=24.622030237581, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI20130357, Length=417, Percent_Identity=25.8992805755396, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648260, Length=399, Percent_Identity=25.5639097744361, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281365686, Length=327, Percent_Identity=25.9938837920489, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=519, Percent_Identity=25.2408477842004, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355181, Length=371, Percent_Identity=24.5283018867925, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358303, Length=332, Percent_Identity=25.3012048192771, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161076582, Length=479, Percent_Identity=24.0083507306889, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648257, Length=366, Percent_Identity=24.5901639344262, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356441, Length=332, Percent_Identity=23.7951807228916, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24648253, Length=342, Percent_Identity=21.6374269005848, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356947, Length=423, Percent_Identity=25.0591016548463, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648255, Length=342, Percent_Identity=21.6374269005848, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 54831; Mature: 54831

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTLADAARAAAQRTPERIALVDNEVRLNCATLYAQAGELAAALLARIPAGSVVSFMLP
CCCHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
NWHEAAVIYLAATLAGMVVNPILPSLRDHDLRFILEDACAAMVFVPHRYGGHDYPAMLDR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
VTAAMSAAPQVVVLRGPATGRTGRHTPYRCMLGGPPGGLPALDPDAVRMILYTSGTTSRP
HHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCC
KGVLHTHNSIHALICQIRDHWAIDPGDTFLVPSPLAHIGGSIYAFECPLLLGTTAVLMDR
CCEEECCCHHHHHHHHHHHCEEECCCCCEECCCCHHHHCCCEEEEECCHHHCCHHHHHCC
WDPARAVALMTAHRCTHMAGATPFLQQLLSAAANARTRLPDLKVFICGGASVSPSLIRRA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
AAYFDRAVVTRVYGCTEVPVATVGAPRPQEADYAADTDGRPGIAEIKLAAHPAAPTGDGE
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
ICVRGPQMLRGYRHPEDDAESFDAAGFFRTGDLGRWALADSAGRYLVVTGRAKDVIIRSG
EEEECHHHHHCCCCCCCHHHHCCCCCCEECCCCCCEEECCCCCCEEEEECCCCEEEEECC
ENISAKEVEDLLADHPGIAEIAVVGLPDERTGERACAVIVPTPGASPDVAGLLALLVSKG
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC
VAKFKAPEQVVLWDALPKNDAGKVLKHRIRAALSKDG
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSTLADAARAAAQRTPERIALVDNEVRLNCATLYAQAGELAAALLARIPAGSVVSFMLP
CCCHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
NWHEAAVIYLAATLAGMVVNPILPSLRDHDLRFILEDACAAMVFVPHRYGGHDYPAMLDR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
VTAAMSAAPQVVVLRGPATGRTGRHTPYRCMLGGPPGGLPALDPDAVRMILYTSGTTSRP
HHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCC
KGVLHTHNSIHALICQIRDHWAIDPGDTFLVPSPLAHIGGSIYAFECPLLLGTTAVLMDR
CCEEECCCHHHHHHHHHHHCEEECCCCCEECCCCHHHHCCCEEEEECCHHHCCHHHHHCC
WDPARAVALMTAHRCTHMAGATPFLQQLLSAAANARTRLPDLKVFICGGASVSPSLIRRA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
AAYFDRAVVTRVYGCTEVPVATVGAPRPQEADYAADTDGRPGIAEIKLAAHPAAPTGDGE
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
ICVRGPQMLRGYRHPEDDAESFDAAGFFRTGDLGRWALADSAGRYLVVTGRAKDVIIRSG
EEEECHHHHHCCCCCCCHHHHCCCCCCEECCCCCCEEECCCCCCEEEEECCCCEEEEECC
ENISAKEVEDLLADHPGIAEIAVVGLPDERTGERACAVIVPTPGASPDVAGLLALLVSKG
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC
VAKFKAPEQVVLWDALPKNDAGKVLKHRIRAALSKDG
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 7984428; 12535077 [H]