Click here to switch to the map view.

The map label for this gene is icd1

Identifier: 41409553

GI number: 41409553

Start: 3834914

End: 3836152

Strand: Reverse

Name: icd1

Synonym: MAP3455c

Alternate gene names: 41409553

Gene position: 3836152-3834914 (Counterclockwise)

Preceding gene: 41409554

Following gene: 41409551

Centisome position: 79.43

GC content: 63.44

Gene sequence:

>1239_bases
ATGTCCAACCCCGCCAACACGTCCAAGATCAAGGTCAAGGGCCGCGTCGTCGAGCTCGACGGTGACGAGATGACCCGGGT
CATCTGGAAGATGATCAAGGAGAACTTGATCCTTCCCTACCTCGACATCGACCTGGACTACTACGACCTGGGCATCGAGC
ACCGCGACCGCACCGACGACCAGGTGACGATCGACGCGGCGTATGCCATCAAGAAGCACGGCGTGGGCGTCAAGTGCGCG
ACGATCACCCCCGACGAGGCGAGGGTCCGGGAGTTCAACCTCAAGAGGATGTGGCTGTCCCCGAACGGGACGATCCGGAA
CATCTTGGGCGGCACCATCTTCCGCGAGCCGATCGTGATATCCAATGTGCCCCGGCTGGTTCCGGGCTGGACCAAGCCGA
TCGTCATCGGCCGCCACGCATTCGGTGACCAGTACCGGTCGACCAACTTCAAGGTGGACAAGCCGGGCACCGTCGCGATC
ACCTTCACTCCCGCCGACGGCAGCGAGCCGATCGTGCACGAGATGGTGTCCATCCCCGAGGACGGCGGGGTGGTGATGGG
GATGTACAACTTCCGGGAGTCGATCCGCGACTTCGCCCGCGCGTCGTTCAAGTACGGCCTGAACGCCAAATGGCCGGTGT
ACCTGTCGACCAAGAACACCATCCTCAAGGCCTACGACGGCATGTTCAAGGACGAGTTCCAGCGCATCTACGACGAGGAA
TTCAAGGAGCAGTTCGAAGCCGAGGGACTGACCTACGAACACCGGCTGATCGACGACATGGTGGCGGCCTGCCTCAAATG
GGAGGGCGGCTACGTGTGGGCCTGCAAGAACTACGACGGCGACGTCCAATCCGACGCGATAGCACAGGGTTACGGCTCGC
TGGGGCTGATGACCTCGGTGCTGATGACCGCCGACGGCAAGACGGTCGAGGCCGAGGCCGCGCACGGCACCGTCACCCGG
CACTTCCGTCAGTACCAGGCCGGCAAGCCGACCTCGACCAACCCGATCGCCTCGATCTTCGCCTGGACGCGCGGGCTGGC
GCACCGCGGCAAGCTGGACGACACCCCCGAGGTGGTCGAGTTCGCGCAGACCCTGGAACGCGTCGTCGTCTCCACCGTGG
AGAGCGGCAAGATGACCAAGGACCTCGCCATCCTGATCGGCCCCGACCAAAAGTGGCAGCAGAGCGAGGAATTCCTCAAC
TCGATCGCCGAGAACCTGCGGCGGGAGCTGACTAACTAG

Upstream 100 bases:

>100_bases
GACATCGGCGGCTACTACCAGCCCGACAGCGAGAAGACCACCGCGGTGATGCGGCCGAGCAAGACGTTCAACGAGGCGCT
GGCCGCGTCGCAGCGCTGAC

Downstream 100 bases:

>100_bases
CGGGGGGCTGCTGGCGCTGGGAGCGGGCCACGCAGTCGTCGATGAAGTCGGTGAGCACCGTTGTGACCCGCTCGGGCGCC
TCGAACATCGGCACGTGTCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDDQVTIDAAYAIKKHGVGVKCA
TITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAI
TFTPADGSEPIVHEMVSIPEDGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEE
FKEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTR
HFRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPEVVEFAQTLERVVVSTVESGKMTKDLAILIGPDQKWQQSEEFLN
SIAENLRRELTN

Sequences:

>Translated_412_residues
MSNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDDQVTIDAAYAIKKHGVGVKCA
TITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAI
TFTPADGSEPIVHEMVSIPEDGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEE
FKEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTR
HFRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPEVVEFAQTLERVVVSTVESGKMTKDLAILIGPDQKWQQSEEFLN
SIAENLRRELTN
>Mature_411_residues
SNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDDQVTIDAAYAIKKHGVGVKCAT
ITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAIT
FTPADGSEPIVHEMVSIPEDGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEEF
KEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRH
FRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPEVVEFAQTLERVVVSTVESGKMTKDLAILIGPDQKWQQSEEFLNS
IAENLRRELTN

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=404, Percent_Identity=65.3465346534654, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=64.7058823529412, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17550822, Length=411, Percent_Identity=62.5304136253041, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17540874, Length=403, Percent_Identity=62.7791563275434, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6324319, Length=403, Percent_Identity=61.2903225806452, Blast_Score=532, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6323203, Length=406, Percent_Identity=60.5911330049261, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320137, Length=413, Percent_Identity=60.0484261501211, Blast_Score=514, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21356561, Length=408, Percent_Identity=63.4803921568627, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221330987, Length=414, Percent_Identity=62.8019323671498, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221330985, Length=414, Percent_Identity=62.8019323671498, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI28574947, Length=414, Percent_Identity=62.8019323671498, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24660849, Length=414, Percent_Identity=62.8019323671498, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24660856, Length=408, Percent_Identity=63.4803921568627, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221330983, Length=408, Percent_Identity=63.4803921568627, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=63.3251833740831, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=63.3251833740831, Blast_Score=534, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46423; Mature: 46292

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDD
CCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCCCCCC
QVTIDAAYAIKKHGVGVKCATITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVI
EEEEEEEHHHHHCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCHHHHHCCHHHCCCEEE
SNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAITFTPADGSEPIVHEMVSIPE
CCCCCCCCCCCCCEEEECHHCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCCC
DGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEE
CCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHH
FKEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLMTSV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHH
LMTADGKTVEAEAAHGTVTRHFRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPEVVE
HHHCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
FAQTLERVVVSTVESGKMTKDLAILIGPDQKWQQSEEFLNSIAENLRRELTN
HHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDD
CCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCCCCCC
QVTIDAAYAIKKHGVGVKCATITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVI
EEEEEEEHHHHHCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCHHHHHCCHHHCCCEEE
SNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAITFTPADGSEPIVHEMVSIPE
CCCCCCCCCCCCCEEEECHHCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCCC
DGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIYDEE
CCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHH
FKEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLMTSV
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHH
LMTADGKTVEAEAAHGTVTRHFRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPEVVE
HHHCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
FAQTLERVVVSTVESGKMTKDLAILIGPDQKWQQSEEFLNSIAENLRRELTN
HHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]