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The map label for this gene is sdhA

Identifier: 41409541

GI number: 41409541

Start: 3821754

End: 3823508

Strand: Direct

Name: sdhA

Synonym: MAP3443

Alternate gene names: 41409541

Gene position: 3821754-3823508 (Clockwise)

Preceding gene: 41409540

Following gene: 41409542

Centisome position: 79.13

GC content: 67.81

Gene sequence:

>1755_bases
ATGATCCAACAACATCGATACGACGTGGTGATCGTCGGCGCCGGCGGTGCCGGGATGCGCGCGGCCGTGGAAGCCGGCCC
GCGGGTGCGCACCGCGGTGCTGACCAAGCTCTACCCCACCCGCAGCCACACCGGGGCGGCCCAGGGCGGCATGTGCGCGG
CGCTGGCCAACGTCGAGGAAGACAACTGGGAATGGCACACCTTCGACACCGTCAAGGGCGGCGACTACCTCGCCGACCAG
GACGCGGTAGAGATCATGTGCAAGGAAGCCATCGACGCGGTGCTCGACCTGGAGAAGATGGGGATGCCGTTCAACCGCAC
CCCCGAGGGCCGCATCGACCAGCGCCGCTTCGGCGGCCACACCCGCGACCACGGCAAGGCCCCGGTGCGCCGGGCCTGTT
ACGCCGCCGACCGCACCGGCCACATGATCCTGCAGACGCTCTACCAGAACTGTGTGCGGCACGACGTGCAGTTCTTCAAC
GAGTTCTACGCGCTGGACCTGGTTTTGACGCAGACACCCAGCGGCCCGGTGGCCAGCGGCGTGGTGGCCTACGAGCTGGC
CACCGGCGACATCCACGTCTTTCACGCCAAGGCCGTCGTGCTCGCCACCGGCGGGTCGGGCCGGATGTACAAGACCACCT
CCAACGCGCACACCCTGACCGGCGACGGCATCGGCATCGTCTTCCGCAAGGGACTTCCCTTGGAGGACATGGAGTTTCAC
CAGTTCCACCCGACCGGCCTGGCCGGATTGGGGATTCTGATCTCCGAGGCGGTGCGCGGCGAGGGCGGCCGGCTGCTCAA
CGGCGAGGGCGAGCGGTTCATGGAGCGCTACGCCCCCACCATCGTCGACCTGGCGCCGCGCGACATCGTCGCGCGCTCAA
TGGTTTTGGAGGTGCTGGAGGGCCGCGGCGCCGGACCGCACAAGGACTACGTCTACATCGACGTGCGCCACCTCGGCGAG
GACGTGCTGGAGTCCAAGCTGCCCGACATCACCGAGTTCGCCCGCACCTACCTGGGCGTGGACCCGGTGCACGAGCTGGT
GCCGGTGTACCCGACGTGCCACTACGTGATGGGCGGCATCCCCACCACGGTCACCGGACAAGTGTTGCGGGACAACACCT
CCACCGTGCCGGGCCTGTACGCGGCCGGCGAGTGCGCGTGCGTGTCGGTGCACGGCGCCAACCGGCTGGGCACCAATTCG
CTGCTGGACATCAACGTGTTCGGCCGCCGGGCCGGCATCGCCGCGGCCAACTACGCCCGGGGCCACGACTTCGTGGACAT
GCCGCCTGACCCGGCGGCGATGGTGGTGCGCTGGGTCGCCGACATCCTCTCCGAGCACGGCAACGAGCGGGTCGCCGACA
TCCGCGGCACGCTGCAGCAGTCGATGGACAACAATGCGGCGGTGTTCCGCACCGAGGAGACGCTCAAGCAGGCGCTGACG
GACATCCACGCGTGCAAGGAGCGGTACTCGCGAATCCGCATCCACGACAAGGGAAAACGATTCAACAGCGACCTGCTGGA
AGCCATCGAGCTGGGCTTCCTGCTGGAGCTGGCCGAGGTCACCGTGGTGGGGGCGCTCAACCGCAAGGAGTCCCGCGGCG
GCCACGCCCGCGAGGACTATCCCAACCGGGACGACGTCAACTACATGCGCCACACCATGGCCTACAAGCAGGGCACCGAT
CTGCTGAGCGACATCGCGCTGGACTTCAAGCCCGTGGTGCAGACGCGCTACGAACCCAAGGAACGGAAGTACTGA

Upstream 100 bases:

>100_bases
TGGCTGAACAGCCTGCTGCTGCTGTCGATGGGCTTCACCCTGGTGCTGGGCACCTACGTGCTGCTGACCTTCGACCCGAA
CATCTCGGGATAGGCGAGTC

Downstream 100 bases:

>100_bases
ATGTCTGTCGAGCCGGACGTCGAAACCTTGGAACCGCCGCTGCCGCCGGTTCCCGACGAAGCGGTGATGGTGACCGTCAA
GATCGCCCGGTTCAACCCCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVRHDVQFFN
EFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
DVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYARGHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALT
DIHACKERYSRIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPKERKY

Sequences:

>Translated_584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVRHDVQFFN
EFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
DVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYARGHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALT
DIHACKERYSRIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPKERKY
>Mature_584_residues
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVRHDVQFFN
EFYALDLVLTQTPSGPVASGVVAYELATGDIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGE
DVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAANYARGHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALT
DIHACKERYSRIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKQGTD
LLSDIALDFKPVVQTRYEPKERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=573, Percent_Identity=47.4694589877836, Blast_Score=505, Evalue=1e-143,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=49.2857142857143, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1790597, Length=572, Percent_Identity=40.034965034965, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=33.213644524237, Blast_Score=228, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=577, Percent_Identity=46.2738301559792, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17505833, Length=524, Percent_Identity=48.4732824427481, Blast_Score=496, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=48.135593220339, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322416, Length=586, Percent_Identity=48.6348122866894, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17137288, Length=569, Percent_Identity=46.9244288224956, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24655642, Length=569, Percent_Identity=46.9244288224956, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24655647, Length=569, Percent_Identity=46.9244288224956, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24663005, Length=601, Percent_Identity=45.0915141430948, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64360; Mature: 64360

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEE
CCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVRHDVQFFNEFYALDLVLTQTPSGPVASG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCC
VVAYELATGDIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
GRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAANYAR
CCHHCCHHHCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHCCCC
GHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHACKERYSRIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PNRDDVNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPKERKY
CCCCHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHCCCCCHHCCC
>Mature Secondary Structure
MIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEE
CCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVRHDVQFFNEFYALDLVLTQTPSGPVASG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCC
VVAYELATGDIHVFHAKAVVLATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
GRGAGPHKDYVYIDVRHLGEDVLESKLPDITEFARTYLGVDPVHELVPVYPTCHYVMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCC
PTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAANYAR
CCHHCCHHHCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHCCCC
GHDFVDMPPDPAAMVVRWVADILSEHGNERVADIRGTLQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHACKERYSRIRIHDKGKRFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PNRDDVNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPKERKY
CCCCHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA