| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is sdhB
Identifier: 41409542
GI number: 41409542
Start: 3823509
End: 3824312
Strand: Direct
Name: sdhB
Synonym: MAP3444
Alternate gene names: 41409542
Gene position: 3823509-3824312 (Clockwise)
Preceding gene: 41409541
Following gene: 41409543
Centisome position: 79.17
GC content: 66.67
Gene sequence:
>804_bases ATGTCTGTCGAGCCGGACGTCGAAACCTTGGAACCGCCGCTGCCGCCGGTTCCCGACGAAGCGGTGATGGTGACCGTCAA GATCGCCCGGTTCAACCCCGACCAGCCCGACGCGTATGCGGAAACCGGTGGCTGGCAAAGCTTTCGGGTGCCGTGCCTGC CCAGTGACCGGATGCTCAACCTGCTGATCTACATCAAGAGCTACCTGGACGGGACGCTGACCTTCCGGCGTTCCTGCGCG CACGGGGTGTGCGGCTCGGACGCCATGCGCATCAACGGTGTCAACCGGCTGGCGTGCAAGGTGCTGATGCGCGATCTGCT GCCCGAGCCCAAGAAGGGCAAGCCGGGCAAGCCGCTGACCATCACGGTCGAGCCGATCCGCGGGCTGCCGGTGGAAAAGG ACCTGGTGGTCGACATGGAGCCGTTCTTCGACGCCTACCGCGCGGTCAAGCCGTACCTGATCACCACCGGCAATCCGCCC ACCCGCGAGCGCATCCAGAGTCCGGCCGACCGGGCCCGCTACGACGACACCACCAAGTGCATCCTGTGCGCGGCATGCAC CACCAGCTGCCCGGTCTTCTGGCACGAGGGCAGCTACTACGGCCCGGCCGCGATCGTCAACGCGCACCGGTTCATCTTCG ACAGCCGCGACGAGGGCGCCGCCGAGCGGCTGGACATCCTCAACGAGGTCGACGGCGTGTGGCGCTGCCGCACCACGTTC AACTGCACCGATGCCTGCCCGCGCGGCATCGAGGTGACCAAGGCCATCCAAGAGGTCAAGCGCGCCATCATGTTCTCCCG CTGA
Upstream 100 bases:
>100_bases CATGGCCTACAAGCAGGGCACCGATCTGCTGAGCGACATCGCGCTGGACTTCAAGCCCGTGGTGCAGACGCGCTACGAAC CCAAGGAACGGAAGTACTGA
Downstream 100 bases:
>100_bases TCGCTCGAGCTTTTGCCCCCTTCTGCCCGCGAGCGTCCCCTTCTGCCCGCGAGCGTCACGTTTTGCCCGCGAGCGTCTCC TTCTGCCCGCGAGCGTCACG
Product: succinate dehydrogenase iron-sulfur subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 267; Mature: 266
Protein sequence:
>267_residues MSVEPDVETLEPPLPPVPDEAVMVTVKIARFNPDQPDAYAETGGWQSFRVPCLPSDRMLNLLIYIKSYLDGTLTFRRSCA HGVCGSDAMRINGVNRLACKVLMRDLLPEPKKGKPGKPLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITTGNPP TRERIQSPADRARYDDTTKCILCAACTTSCPVFWHEGSYYGPAAIVNAHRFIFDSRDEGAAERLDILNEVDGVWRCRTTF NCTDACPRGIEVTKAIQEVKRAIMFSR
Sequences:
>Translated_267_residues MSVEPDVETLEPPLPPVPDEAVMVTVKIARFNPDQPDAYAETGGWQSFRVPCLPSDRMLNLLIYIKSYLDGTLTFRRSCA HGVCGSDAMRINGVNRLACKVLMRDLLPEPKKGKPGKPLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITTGNPP TRERIQSPADRARYDDTTKCILCAACTTSCPVFWHEGSYYGPAAIVNAHRFIFDSRDEGAAERLDILNEVDGVWRCRTTF NCTDACPRGIEVTKAIQEVKRAIMFSR >Mature_266_residues SVEPDVETLEPPLPPVPDEAVMVTVKIARFNPDQPDAYAETGGWQSFRVPCLPSDRMLNLLIYIKSYLDGTLTFRRSCAH GVCGSDAMRINGVNRLACKVLMRDLLPEPKKGKPGKPLTITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITTGNPPT RERIQSPADRARYDDTTKCILCAACTTSCPVFWHEGSYYGPAAIVNAHRFIFDSRDEGAAERLDILNEVDGVWRCRTTFN CTDACPRGIEVTKAIQEVKRAIMFSR
Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]
COG id: COG0479
COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]
Homologues:
Organism=Homo sapiens, GI115387094, Length=239, Percent_Identity=38.0753138075314, Blast_Score=161, Evalue=7e-40, Organism=Escherichia coli, GI1786943, Length=245, Percent_Identity=41.6326530612245, Blast_Score=184, Evalue=5e-48, Organism=Escherichia coli, GI1790596, Length=241, Percent_Identity=37.344398340249, Blast_Score=159, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17533915, Length=244, Percent_Identity=39.344262295082, Blast_Score=157, Evalue=5e-39, Organism=Saccharomyces cerevisiae, GI6322987, Length=246, Percent_Identity=37.8048780487805, Blast_Score=174, Evalue=2e-44, Organism=Drosophila melanogaster, GI17137106, Length=257, Percent_Identity=38.5214007782101, Blast_Score=169, Evalue=1e-42, Organism=Drosophila melanogaster, GI24643156, Length=248, Percent_Identity=37.5, Blast_Score=159, Evalue=1e-39,
Paralogues:
None
Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR017896 - InterPro: IPR017900 - InterPro: IPR012675 - InterPro: IPR001041 - InterPro: IPR012285 - InterPro: IPR009051 - InterPro: IPR004489 [H]
Pfam domain/function: NA
EC number: =1.3.99.1 [H]
Molecular weight: Translated: 29857; Mature: 29725
Theoretical pI: Translated: 6.72; Mature: 6.72
Prosite motif: PS00198 4FE4S_FERREDOXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
4.1 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 6.7 %Cys+Met (Translated Protein) 4.1 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 6.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVEPDVETLEPPLPPVPDEAVMVTVKIARFNPDQPDAYAETGGWQSFRVPCLPSDRMLN CCCCCCHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHCCCCCCEECCCCCCHHHHH LLIYIKSYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDLLPEPKKGKPGKPLT HHHHHHHHHCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEE ITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITTGNPPTRERIQSPADRARYDDTTKC EEECCCCCCCCCCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHCCCCCCCE ILCAACTTSCPVFWHEGSYYGPAAIVNAHRFIFDSRDEGAAERLDILNEVDGVWRCRTTF EEEEECCCCCCEEEECCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEEC NCTDACPRGIEVTKAIQEVKRAIMFSR CCHHCCCCCCHHHHHHHHHHHHHHCCC >Mature Secondary Structure SVEPDVETLEPPLPPVPDEAVMVTVKIARFNPDQPDAYAETGGWQSFRVPCLPSDRMLN CCCCCHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHCCCCCCEECCCCCCHHHHH LLIYIKSYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDLLPEPKKGKPGKPLT HHHHHHHHHCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEE ITVEPIRGLPVEKDLVVDMEPFFDAYRAVKPYLITTGNPPTRERIQSPADRARYDDTTKC EEECCCCCCCCCCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHCCCCCCCE ILCAACTTSCPVFWHEGSYYGPAAIVNAHRFIFDSRDEGAAERLDILNEVDGVWRCRTTF EEEEECCCCCCEEEECCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEEC NCTDACPRGIEVTKAIQEVKRAIMFSR CCHHCCCCCCHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 7.0
TargetDB status: NA
Availability: NA
References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]