BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

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The map label for this gene is kduD [H]

Identifier: 41409426

GI number: 41409426

Start: 3697020

End: 3697769

Strand: Reverse

Name: kduD [H]

Synonym: MAP3328c

Alternate gene names: 41409426

Gene position: 3697769-3697020 (Counterclockwise)

Preceding gene: 41409427

Following gene: 41409425

Centisome position: 76.56

GC content: 68.13

Gene sequence:

>750_bases
ATGAACACCGTCCACTTCGACTTCACCGACGCCCGGGTGCTGGTGACCGGCGGCACCAGCGGCATCGGCAACGCGATCGC
CACCGCCTTCGCCGACTCCGGGGCCGCCGTCACGGTGACCGGAACCCGCGCCGCGGCCACCGGCTATCCCGACATCGACC
TCGGTGCGTTCAGCTACCGGCAGTGCCACATCCAGGATCCGGAATCCGTTGACGCCCTGGCGAACTCACTGTCAGATCTG
GACATACTGGTCAACAACGCCGGCGGGCCCTACCCCGCGGGCGACGAATACGACCCGGACGGCTACGTCGCCTCGGTGAC
GCAAAACATGTTCGGCCCGATGCGGCTGACCATGCGCTGTCATGACCTGCTCAAGTCCAGCCGGGCCGCCGGCGGCGCCA
GTGTGGTCAACGTCGTCTCGATGTCGGCGTTCCGCTCGGCGGTCTTCGTCCCCGGCTACGCGTCGTCGAAGATGGGGCTG
GTCGCCCTGACCATGAACCTGTCCCGCCGCTGGGCCGGCGACGGGATCCGGGTCAACGCCATCGCCCCCGGGCTGATCGA
CACCCGAATGACCCACCCCGCCATGGGAATTCCCGAAGTGATGGACGTCGAGATCGGCTTTCACACCCCGCTGGGCCGGC
CGGGCACGCCCGCGGACTGCGCCGGGGCCGCGCTGTTTTTGTGTACCGAGGCGGCGTCGTACATCACGGGCAGCACGATT
GCGGTCGACGGCGGATACCTGACGGTCTAG

Upstream 100 bases:

>100_bases
CGGTCGCCGCCGACGCCCACGAGGCGCTGCTGGCCGGCACCGAAAACTTCTGGGAGAAAGCCTGGCTCACCAAATCGATC
CGCGAATTGAGGGACCCGGA

Downstream 100 bases:

>100_bases
GGCCATGAGCGACTTCGACAACATCACCACCGCCGACGACGTCTTCAAGCTGGCCGCGCAGCGCACCGGCCTCAGCGAAA
TCGACTCCGACTCTTGGCGA

Product: hypothetical protein

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNTVHFDFTDARVLVTGGTSGIGNAIATAFADSGAAVTVTGTRAAATGYPDIDLGAFSYRQCHIQDPESVDALANSLSDL
DILVNNAGGPYPAGDEYDPDGYVASVTQNMFGPMRLTMRCHDLLKSSRAAGGASVVNVVSMSAFRSAVFVPGYASSKMGL
VALTMNLSRRWAGDGIRVNAIAPGLIDTRMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGAALFLCTEAASYITGSTI
AVDGGYLTV

Sequences:

>Translated_249_residues
MNTVHFDFTDARVLVTGGTSGIGNAIATAFADSGAAVTVTGTRAAATGYPDIDLGAFSYRQCHIQDPESVDALANSLSDL
DILVNNAGGPYPAGDEYDPDGYVASVTQNMFGPMRLTMRCHDLLKSSRAAGGASVVNVVSMSAFRSAVFVPGYASSKMGL
VALTMNLSRRWAGDGIRVNAIAPGLIDTRMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGAALFLCTEAASYITGSTI
AVDGGYLTV
>Mature_249_residues
MNTVHFDFTDARVLVTGGTSGIGNAIATAFADSGAAVTVTGTRAAATGYPDIDLGAFSYRQCHIQDPESVDALANSLSDL
DILVNNAGGPYPAGDEYDPDGYVASVTQNMFGPMRLTMRCHDLLKSSRAAGGASVVNVVSMSAFRSAVFVPGYASSKMGL
VALTMNLSRRWAGDGIRVNAIAPGLIDTRMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGAALFLCTEAASYITGSTI
AVDGGYLTV

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=29.3172690763052, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=33.8842975206612, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=30.8, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503301, Length=194, Percent_Identity=29.8969072164948, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5031737, Length=241, Percent_Identity=31.1203319502075, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=28.8973384030418, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=29.5154185022026, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=28.515625, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI66933014, Length=230, Percent_Identity=25.2173913043478, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=27.843137254902, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=27.3092369477912, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=34.0248962655602, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=31.1023622047244, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=30.2788844621514, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=31.640625, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=29.1338582677165, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=26.1363636363636, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=28.0632411067194, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.1740890688259, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=29.1187739463602, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=29.3877551020408, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788459, Length=269, Percent_Identity=27.1375464684015, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=245, Percent_Identity=31.0204081632653, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=33.8709677419355, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=31.2267657992565, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=29.0836653386454, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=31.1787072243346, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=30.9160305343511, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=243, Percent_Identity=30.8641975308642, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.0751879699248, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=30.9433962264151, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=29.4776119402985, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=31.3207547169811, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.1526717557252, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=30.241935483871, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=29.6992481203008, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=31.203007518797, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=31.0756972111554, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.2238805970149, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=28.8, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=29.0566037735849, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=29.277566539924, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=245, Percent_Identity=28.9795918367347, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=27.9245283018868, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=29.6, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=30.5785123966942, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=29.4354838709677, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=29.8039215686275, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=29.6, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=29.8449612403101, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=29.0196078431373, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643142, Length=263, Percent_Identity=28.1368821292776, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24644337, Length=189, Percent_Identity=32.2751322751323, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 25733; Mature: 25733

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVHFDFTDARVLVTGGTSGIGNAIATAFADSGAAVTVTGTRAAATGYPDIDLGAFSYR
CCEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCEECCCCCCCCCCCEEEE
QCHIQDPESVDALANSLSDLDILVNNAGGPYPAGDEYDPDGYVASVTQNMFGPMRLTMRC
EECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHH
HDLLKSSRAAGGASVVNVVSMSAFRSAVFVPGYASSKMGLVALTMNLSRRWAGDGIRVNA
HHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCHHCCCCCEEEEE
IAPGLIDTRMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGAALFLCTEAASYITGSTI
ECCCHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
AVDGGYLTV
EECCCEEEC
>Mature Secondary Structure
MNTVHFDFTDARVLVTGGTSGIGNAIATAFADSGAAVTVTGTRAAATGYPDIDLGAFSYR
CCEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCEECCCCCCCCCCCEEEE
QCHIQDPESVDALANSLSDLDILVNNAGGPYPAGDEYDPDGYVASVTQNMFGPMRLTMRC
EECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHH
HDLLKSSRAAGGASVVNVVSMSAFRSAVFVPGYASSKMGLVALTMNLSRRWAGDGIRVNA
HHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCHHCCCCCEEEEE
IAPGLIDTRMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGAALFLCTEAASYITGSTI
ECCCHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
AVDGGYLTV
EECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]