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The map label for this gene is gutB [H]

Identifier: 41409424

GI number: 41409424

Start: 3694824

End: 3695771

Strand: Reverse

Name: gutB [H]

Synonym: MAP3326c

Alternate gene names: 41409424

Gene position: 3695771-3694824 (Counterclockwise)

Preceding gene: 41409425

Following gene: 41409422

Centisome position: 76.52

GC content: 68.57

Gene sequence:

>948_bases
GTGGGCCCGCGCGACGTCCTGGTGCGGATGCGTGCCTGCGGCATCTGCGGCTCCGACGCGTTCTACATCAGCATCGGCGG
CGTCCCGCCGCGGCAGGGACACACCCCGCTGGGGCACGAACCGGCCGGCGAGGTCGTCGAGGTCGGCGCCGAGGTGACCG
GGCTGGCCGTCGGTGACCACGTCGTCATCAACCCGATGGCCGCGCCCAGCGGCATCATCGGCAACGGCGGCGCCAGCGGG
GCGCTCGCCGACTACCTGCTGATCGAAAACGCCGTCCGCGGAACAAGTCTCGAGGTCATTCCGGACCACATCCCGTGGGA
GGTGGCGGCGCTCAACGAACCGATGGCCGTCGCGCGCCACGGCGTCAACCGCTGTCAACCCCGACCCACGGACAAGGTCG
TCGTCTTCGGCGCCGGCCCGATCGGGCTGGGCGCCACGCTGGCCTTCAAATCCCTCGGCGTGCAGCACATCGTGGTCATC
GATCTGATTCCCGGGCGCCTGGACAAGGCAGTGCGGATCGGCGCCGACGCGGTCGTCAACTCCGCCGAAGAAGACGTGGC
GGCGCGCCTGGTCGAACTGCACGGCTCGGGCGAGAGCATGTTCCCCGGCAAGGCCGGCACCGACATCTACCTCGACGCCG
CCGGCGCGCCAGCCGTCGTCAGCACCGCGCTGGCCGCCGCCAAGAAGGGCGCCACGTTGGGAATCGTTGGCGTGCACAAG
GAACCGGTGCCCGTCGACCTGATCAACGTGATGAGCAACGAGATCACCATCGTCGGGAGCATGGGTTATCCGGACGAAAT
CTTCGAAGTGACCGGCGATCTGGTGAGGAACTGGGAGAAGTACGCGCTGATCGTCAGCCACACCATTCCGTTCGACCGCG
TCGGCGAGGCGCTCGAACTGGCCCGTACTCCCGGCGCCGCCGACAAGGTCGTCGTCACCTTCTGCTGA

Upstream 100 bases:

>100_bases
ACCTCGACACCTTCGACATCGAACTGGAAGGCACGCCGTGAAAGCATCCGTGGTCACCGGCCCGCGCCGGGTCGAGGTCG
TCGACGTCGAGCGCCCCGAC

Downstream 100 bases:

>100_bases
CCGGCCTACGAACGGGCGTTGCTAGGGGCCGGTGTATCCCGGCGGGTTGACGCCGTCCACCCAAAAGTCCACGCCCAGTT
GGGATCCCGGCACGCAGTTG

Product: hypothetical protein

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MGPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDHVVINPMAAPSGIIGNGGASG
ALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNRCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVI
DLIPGRLDKAVRIGADAVVNSAEEDVAARLVELHGSGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHK
EPVPVDLINVMSNEITIVGSMGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALELARTPGAADKVVVTFC

Sequences:

>Translated_315_residues
MGPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDHVVINPMAAPSGIIGNGGASG
ALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNRCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVI
DLIPGRLDKAVRIGADAVVNSAEEDVAARLVELHGSGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHK
EPVPVDLINVMSNEITIVGSMGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALELARTPGAADKVVVTFC
>Mature_314_residues
GPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDHVVINPMAAPSGIIGNGGASGA
LADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNRCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVID
LIPGRLDKAVRIGADAVVNSAEEDVAARLVELHGSGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHKE
PVPVDLINVMSNEITIVGSMGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALELARTPGAADKVVVTFC

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=319, Percent_Identity=31.3479623824451, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1788073, Length=317, Percent_Identity=29.3375394321767, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=28.2738095238095, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787863, Length=329, Percent_Identity=27.0516717325228, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=316, Percent_Identity=28.1645569620253, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=340, Percent_Identity=24.7058823529412, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=27.2463768115942, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=333, Percent_Identity=27.3273273273273, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=328, Percent_Identity=26.219512195122, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=280, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=281, Percent_Identity=28.8256227758007, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=324, Percent_Identity=27.7777777777778, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=320, Percent_Identity=27.8125, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=320, Percent_Identity=27.8125, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=316, Percent_Identity=27.5316455696203, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=307, Percent_Identity=27.3615635179153, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=324, Percent_Identity=30.2469135802469, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=28.8288288288288, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 32546; Mature: 32415

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDH
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCE
VVINPMAAPSGIIGNGGASGALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARH
EEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCHHHHHC
GVNRCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRIGADAVVN
CHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHCCHHHHHC
SAEEDVAARLVELHGSGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHK
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCC
EPVPVDLINVMSNEITIVGSMGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALEL
CCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
ARTPGAADKVVVTFC
HCCCCCCCEEEEEEC
>Mature Secondary Structure 
GPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTGLAVGDH
CHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCE
VVINPMAAPSGIIGNGGASGALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARH
EEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCHHHHHC
GVNRCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRIGADAVVN
CHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHCCHHHHHC
SAEEDVAARLVELHGSGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHK
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCC
EPVPVDLINVMSNEITIVGSMGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALEL
CCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
ARTPGAADKVVVTFC
HCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]