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The map label for this gene is devR [H]

Identifier: 41409369

GI number: 41409369

Start: 3631486

End: 3632154

Strand: Reverse

Name: devR [H]

Synonym: MAP3271c

Alternate gene names: 41409369

Gene position: 3632154-3631486 (Counterclockwise)

Preceding gene: 41409371

Following gene: 41409368

Centisome position: 75.2

GC content: 69.36

Gene sequence:

>669_bases
ATGGTCAAGGTGTTCCTGGTCGACGACCACGAAGTCGTCCGCCGCGGACTGTGCGATCTGCTCTCCTCGGATCCCGATCT
GCAGATCGTCGGCGAGGCCGGCACGGTGGCCGAGGCCAAGGCGCGGATACCGGCGGCGCGGCCCGACGTGGCCGTGCTCG
ACGTGCGGCTGCCCGACGGCAACGGCATCGAGTTGTGCCGCGACCTGCTCTCCGAGCATCCCGACCTGCGCTGCCTGATG
CTGACGTCGTTCACCTCCGACGAGGCGATGCTGGAGGCCATCCTGGCCGGCGCCAGCGGGTTCGTCATCAAGGACATCAA
GGGCATGGAGCTGGCCCGGGCGATCAAAGACGTGGGCGCCGGGAAATCGCTGCTGGACAACCGGGCCGCCGCCGCGTTGA
TGGCCAAGCTGCGCGGCAGCGCCGCGCAGGCGGACCCGCTGTCGGGCCTGACCGAACAGGAACGAACGCTGCTCGGGCTG
CTCAGCGAGGGCCTGACCAACCGGCAGATCGCCGCGCGAATGTTCCTCGCGGAGAAGACGGTCAAGAACTACGTGTCCCG
GCTGCTGGCCAAACTCGGCATGGAGCGCCGGACCCAGGCGGCGGTGTTCGCGTCGAAACTCAACCAGCAGGCCGGCCGTC
CGCCGACCCCACCGGACTGGCCGGGGTGA

Upstream 100 bases:

>100_bases
TCTGCGGTCGGGACCAAAGTCGTTGAACCAGTTACGCCCCGACCCGCAGGGAGCCGAGAATGTGGGATATTGGACTGGTC
TGCCGACAGGAAGGCTCGCC

Downstream 100 bases:

>100_bases
CCGGGAACCGGTTCGACGAACTGGCGGCCGCGCGCGATCAAACCGAGAAACTGCTGCGGGTGATCGCCGAGATCGGCGCG
GGCCTGGATCTCGACGCGAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MVKVFLVDDHEVVRRGLCDLLSSDPDLQIVGEAGTVAEAKARIPAARPDVAVLDVRLPDGNGIELCRDLLSEHPDLRCLM
LTSFTSDEAMLEAILAGASGFVIKDIKGMELARAIKDVGAGKSLLDNRAAAALMAKLRGSAAQADPLSGLTEQERTLLGL
LSEGLTNRQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFASKLNQQAGRPPTPPDWPG

Sequences:

>Translated_222_residues
MVKVFLVDDHEVVRRGLCDLLSSDPDLQIVGEAGTVAEAKARIPAARPDVAVLDVRLPDGNGIELCRDLLSEHPDLRCLM
LTSFTSDEAMLEAILAGASGFVIKDIKGMELARAIKDVGAGKSLLDNRAAAALMAKLRGSAAQADPLSGLTEQERTLLGL
LSEGLTNRQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFASKLNQQAGRPPTPPDWPG
>Mature_222_residues
MVKVFLVDDHEVVRRGLCDLLSSDPDLQIVGEAGTVAEAKARIPAARPDVAVLDVRLPDGNGIELCRDLLSEHPDLRCLM
LTSFTSDEAMLEAILAGASGFVIKDIKGMELARAIKDVGAGKSLLDNRAAAALMAKLRGSAAQADPLSGLTEQERTLLGL
LSEGLTNRQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFASKLNQQAGRPPTPPDWPG

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=34.6534653465347, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=32.3383084577114, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=31.3725490196078, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788222, Length=195, Percent_Identity=27.6923076923077, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23797; Mature: 23797

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVFLVDDHEVVRRGLCDLLSSDPDLQIVGEAGTVAEAKARIPAARPDVAVLDVRLPDG
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCC
NGIELCRDLLSEHPDLRCLMLTSFTSDEAMLEAILAGASGFVIKDIKGMELARAIKDVGA
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCC
GKSLLDNRAAAALMAKLRGSAAQADPLSGLTEQERTLLGLLSEGLTNRQIAARMFLAEKT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VKNYVSRLLAKLGMERRTQAAVFASKLNQQAGRPPTPPDWPG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVKVFLVDDHEVVRRGLCDLLSSDPDLQIVGEAGTVAEAKARIPAARPDVAVLDVRLPDG
CEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCC
NGIELCRDLLSEHPDLRCLMLTSFTSDEAMLEAILAGASGFVIKDIKGMELARAIKDVGA
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCC
GKSLLDNRAAAALMAKLRGSAAQADPLSGLTEQERTLLGLLSEGLTNRQIAARMFLAEKT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VKNYVSRLLAKLGMERRTQAAVFASKLNQQAGRPPTPPDWPG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]