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The map label for this gene is fdh [H]

Identifier: 41409361

GI number: 41409361

Start: 3623722

End: 3624903

Strand: Reverse

Name: fdh [H]

Synonym: MAP3263c

Alternate gene names: 41409361

Gene position: 3624903-3623722 (Counterclockwise)

Preceding gene: 41409362

Following gene: 41409360

Centisome position: 75.05

GC content: 69.04

Gene sequence:

>1182_bases
ATGAAGGCTGTCACGTGGCACGGCAAACGCGATGTGCGGGTGGACTCGGTGCCCGATCCCAAGATCGAGCAGCCCACCGA
CGCGATCATCGAGGTCACCTCGACCAACATCTGCGGTTCGGATCTGCACCTCTACGAGATCCTCGGGGCTTTCATGAAGC
CCGGGGACATCCTGGGGCACGAACCGATGGGCGTCGTGCGCGAGGTCGGCACCGAAACCGGCGACCTGCGCGTCGGCGAC
CGCGTGGTCATCCCCTTCCAAATCTGTTGCGGCAGTTGCTACATGTGCGGCCAGCAGCTGTACACCCAGTGCGAGACCAC
CCAGGTGCGCGACCAGGGCATGGGGGCGGCGCTGTTCGGCTATTCCGAGCTCTACGGTGAAGTCCCCGGCGGGCAGGCCG
AGCTGCTGCGGGTGCCGCAGGCCCAGTTCACCCACATCAAAGTGCCTGTGGGACCGCCGGATTCGCGGTTCGTCTACCTC
TCCGACGTGCTGCCCACCGCGTGGCAGGCGGTGGCCTACGCCGACATCCCCGATGGCGGCACGGTCGCGGTGCTCGGCCT
GGGGCCGATCGGCGACATGGCCGCCCGCATCGCCGATCACCTCGGCTACCGGGTCATCGCGGTCGACCTGGTGCCCGAGC
GGCTGGGCCGGGCCGCGCAACGCGGAATCCACACCATCGACCTGGCGCGGCTGGACGCCGGGCTCGGTGACGCGATCCGG
GACCTGACCGACGGCCGCGGCGCCGACTCGGTGATCGACGCGGTGGGCATGGAGGCGCACGGCTCGCCGGCGGCCAAGCT
GGCCCAGCAGGTGGCCGGCGTGCTGCCGGACGCGCTCGGCAAGCGGCTGATGCAGACCGCGGGCGTGGACCGGCTGTCGG
CGCTGTACTCGGCGATCGATGCCGTGCGGCGCGGCGGGACGATCTCGCTGATCGGGGTGTACGGCGGGATGGCCGACCCG
CTGCCGATGCTCACCCTGTTCGACAAGCAGGTCACGCTGCGGATGGGGCAGGCCAACGTCAAGCGCTGGGTCGACGACAT
CATGCCGCTGCTCACCGACGACGATCCGCTGGGCGTGGACGACTTCGCCACCCACGTGCTGCCGCTGGAGCGGGCCCCGC
ACGCCTATGAGATCTTCCAGAAGAAGCAGGACGGAGCGGTCAAAGTCATACTCAAGCCGTAA

Upstream 100 bases:

>100_bases
CGTTGTGGGTCAGCACCCCGACGACGGGCGGTACCCGCGCTGCGCGGGCTCAACCGCGGCTGCCGTTTCGGCGCTGAGCG
GGCGGGTATGCGCCCCCGGC

Downstream 100 bases:

>100_bases
TCGCTTCTACGGCAACGCATTCCGCTTCCCACCGGCAACGCCGCCACGGGCGCCCGAGTTTGACGGGCGCACCGGCAGGG
TATTGAATGCGCCATGACCT

Product: hypothetical protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGHEPMGVVREVGTETGDLRVGD
RVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQAQFTHIKVPVGPPDSRFVYL
SDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDMAARIADHLGYRVIAVDLVPERLGRAAQRGIHTIDLARLDAGLGDAIR
DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKRLMQTAGVDRLSALYSAIDAVRRGGTISLIGVYGGMADP
LPMLTLFDKQVTLRMGQANVKRWVDDIMPLLTDDDPLGVDDFATHVLPLERAPHAYEIFQKKQDGAVKVILKP

Sequences:

>Translated_393_residues
MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGHEPMGVVREVGTETGDLRVGD
RVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQAQFTHIKVPVGPPDSRFVYL
SDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDMAARIADHLGYRVIAVDLVPERLGRAAQRGIHTIDLARLDAGLGDAIR
DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKRLMQTAGVDRLSALYSAIDAVRRGGTISLIGVYGGMADP
LPMLTLFDKQVTLRMGQANVKRWVDDIMPLLTDDDPLGVDDFATHVLPLERAPHAYEIFQKKQDGAVKVILKP
>Mature_393_residues
MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGHEPMGVVREVGTETGDLRVGD
RVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQAQFTHIKVPVGPPDSRFVYL
SDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDMAARIADHLGYRVIAVDLVPERLGRAAQRGIHTIDLARLDAGLGDAIR
DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKRLMQTAGVDRLSALYSAIDAVRRGGTISLIGVYGGMADP
LPMLTLFDKQVTLRMGQANVKRWVDDIMPLLTDDDPLGVDDFATHVLPLERAPHAYEIFQKKQDGAVKVILKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=43.2432432432432, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI87082125, Length=258, Percent_Identity=32.5581395348837, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=271, Percent_Identity=30.6273062730627, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=359, Percent_Identity=26.7409470752089, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790718, Length=366, Percent_Identity=24.8633879781421, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787863, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=250, Percent_Identity=30.4, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788075, Length=214, Percent_Identity=29.4392523364486, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788407, Length=277, Percent_Identity=25.9927797833935, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=290, Percent_Identity=28.9655172413793, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=265, Percent_Identity=29.4339622641509, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=277, Percent_Identity=27.4368231046931, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42142; Mature: 42142

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGH
CCCEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCC
EPMGVVREVGTETGDLRVGDRVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFG
CCHHHHHHHCCCCCCEEECCEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
YSELYGEVPGGQAELLRVPQAQFTHIKVPVGPPDSRFVYLSDVLPTAWQAVAYADIPDGG
HHHHHCCCCCCHHHHEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHEEEEECCCCC
TVAVLGLGPIGDMAARIADHLGYRVIAVDLVPERLGRAAQRGIHTIDLARLDAGLGDAIR
EEEEEECCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEHHHHCCCCHHHHH
DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKRLMQTAGVDRLSALYSAID
HHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHH
AVRRGGTISLIGVYGGMADPLPMLTLFDKQVTLRMGQANVKRWVDDIMPLLTDDDPLGVD
HHHCCCCEEEEEECCCCCCCCHHHHHHCCHHEEEECHHHHHHHHHHHHHHHCCCCCCCHH
DFATHVLPLERAPHAYEIFQKKQDGAVKVILKP
HHHHHHCCCCCCCHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLYEILGAFMKPGDILGH
CCCEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCC
EPMGVVREVGTETGDLRVGDRVVIPFQICCGSCYMCGQQLYTQCETTQVRDQGMGAALFG
CCHHHHHHHCCCCCCEEECCEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
YSELYGEVPGGQAELLRVPQAQFTHIKVPVGPPDSRFVYLSDVLPTAWQAVAYADIPDGG
HHHHHCCCCCCHHHHEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHEEEEECCCCC
TVAVLGLGPIGDMAARIADHLGYRVIAVDLVPERLGRAAQRGIHTIDLARLDAGLGDAIR
EEEEEECCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEHHHHCCCCHHHHH
DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKRLMQTAGVDRLSALYSAID
HHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHH
AVRRGGTISLIGVYGGMADPLPMLTLFDKQVTLRMGQANVKRWVDDIMPLLTDDDPLGVD
HHHCCCCEEEEEECCCCCCCCHHHHHHCCHHEEEECHHHHHHHHHHHHHHHCCCCCCCHH
DFATHVLPLERAPHAYEIFQKKQDGAVKVILKP
HHHHHHCCCCCCCHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]