Click here to switch to the map view.

The map label for this gene is nuoH

Identifier: 41409306

GI number: 41409306

Start: 3558864

End: 3560093

Strand: Direct

Name: nuoH

Synonym: MAP3208

Alternate gene names: 41409306

Gene position: 3558864-3560093 (Clockwise)

Preceding gene: 41409305

Following gene: 41409307

Centisome position: 73.69

GC content: 66.1

Gene sequence:

>1230_bases
GTGCTGGGCAAGGCGCTGGCCATCTTCGTGTTCCTCATGCTCAACGTGCTGGTCGCGATCCTGCTCGAACGCAAGATCCT
CGGCTGGATGCAGCTGCGGCCCGGCCCCAACCGGGTGGGCCCGTGGGGTGTGCTGCAGAGCCTGGCCGACGGAATCAAGT
TGGCGCTCAAGGAAACCATCACCCCGGGCGGTGTCGACAAATTCGTCTACTTCGCGGCGCCGGTCATCTCGACCATCCCC
GCCTTCACCGCGTTCGCGTTCATCCCGTTCGGCCCGGTGGTGTCGGTGTTCGGCCACCGCACCCCGCTTCAGCTCACCGA
CCTGCCGGTCGCGGTGCTGTTCATCCTGGGCCTGTCGGCGATCGGGGTGTACGGAATCGTGTTGGGCGGCTGGGCATCCG
GCTCAACCTACCCGCTGCTGGGCGGGGTGCGCTCCACCGCGCAGGTGATCTCCTACGAGGTGGCGATGGGGTTGTCGTTC
GCGGCGGTGTTCCTCTACGCCGGCTCCATGTCCACCTCGCAGATCGTGGCCGCCCAGGACCGGGTCTGGTTCGTGTTCCT
GCTGCTGCCGTCGTTCGTGATCTACCTGATCTCGATGGTCGGTGAAACCAACCGGGCGCCTTTCGATTTGCCCGAGGCCG
AGGGCGAGCTGGTGGCCGGGTTCCACACCGAGTACTCGTCGCTGAAGTTCGCCATGTTCATGCTGGCCGAGTACGTCAAC
ATGATGACGGTGTCGTCACTGGCCACCGCGTTGTTCTTCGGCGGCTGGCATGCGCCGTGGCCGCTGAACATGTGGGCGGG
CGCCAACACCGGCTGGTGGCCGGTGCTGTGGTTCACCGCGAAGATGTGGACCTTCCTGTTCATCTACTTCTGGCTGCGGG
CCAGCCTGCCGCGGCTGCGCTACGACCAGTTCATGGGGCTGGGCTGGAAGCTGCTGATCCCCGCCTCGTTGGTGTGGGTG
CTGATCGCGGCGGTGATCCGCACGCTGCAGAACCAGGGGTACGCGCACTGGACGCCGATCCTGGTGATCTCCAGCATCGT
GTTCGCCGCCGCCCTGGTGCTCTCGCTGCGAAAACCGTTCACCACGCCGCATATTCGCGCGCTGCGACGGCAGCTGCGCC
GGAAGGCCAAGCAGCTGCCCACCGCGCCGGATTCCACCCCGGTATTCCCGACACCGCCGCTGCCGGCGAAAGCGCTGGCG
GCCGCGAGTAAGGAGAAAGCACGTGGCTAA

Upstream 100 bases:

>100_bases
GCACCGCCAGCTCGGCGTCACCGTCGGCGCCACGGTGCGGATTGGAGTTGGCTCGTGACGACCCCCACTGACCGCCTTCG
GGCACGACCCCTGGTGGCTG

Downstream 100 bases:

>100_bases
ATTCTTGGACGCGGTCGCCGGATTCGGCGTGACGTTCGCGTCGATGTTCAAAAAGCATGTCACCGAGGAGTATCCGGAGA
AGCCGGGCCCGGTCGCGCCG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLGKALAIFVFLMLNVLVAILLERKILGWMQLRPGPNRVGPWGVLQSLADGIKLALKETITPGGVDKFVYFAAPVISTIP
AFTAFAFIPFGPVVSVFGHRTPLQLTDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSF
AAVFLYAGSMSTSQIVAAQDRVWFVFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVN
MMTVSSLATALFFGGWHAPWPLNMWAGANTGWWPVLWFTAKMWTFLFIYFWLRASLPRLRYDQFMGLGWKLLIPASLVWV
LIAAVIRTLQNQGYAHWTPILVISSIVFAAALVLSLRKPFTTPHIRALRRQLRRKAKQLPTAPDSTPVFPTPPLPAKALA
AASKEKARG

Sequences:

>Translated_409_residues
MLGKALAIFVFLMLNVLVAILLERKILGWMQLRPGPNRVGPWGVLQSLADGIKLALKETITPGGVDKFVYFAAPVISTIP
AFTAFAFIPFGPVVSVFGHRTPLQLTDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSF
AAVFLYAGSMSTSQIVAAQDRVWFVFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVN
MMTVSSLATALFFGGWHAPWPLNMWAGANTGWWPVLWFTAKMWTFLFIYFWLRASLPRLRYDQFMGLGWKLLIPASLVWV
LIAAVIRTLQNQGYAHWTPILVISSIVFAAALVLSLRKPFTTPHIRALRRQLRRKAKQLPTAPDSTPVFPTPPLPAKALA
AASKEKARG
>Mature_409_residues
MLGKALAIFVFLMLNVLVAILLERKILGWMQLRPGPNRVGPWGVLQSLADGIKLALKETITPGGVDKFVYFAAPVISTIP
AFTAFAFIPFGPVVSVFGHRTPLQLTDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSF
AAVFLYAGSMSTSQIVAAQDRVWFVFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVN
MMTVSSLATALFFGGWHAPWPLNMWAGANTGWWPVLWFTAKMWTFLFIYFWLRASLPRLRYDQFMGLGWKLLIPASLVWV
LIAAVIRTLQNQGYAHWTPILVISSIVFAAALVLSLRKPFTTPHIRALRRQLRRKAKQLPTAPDSTPVFPTPPLPAKALA
AASKEKARG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=298, Percent_Identity=37.5838926174497, Blast_Score=201, Evalue=8e-52,
Organism=Escherichia coli, GI1788618, Length=311, Percent_Identity=40.1929260450161, Blast_Score=226, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44972; Mature: 44972

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA