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The map label for this gene is nuoD

Identifier: 41409302

GI number: 41409302

Start: 3552973

End: 3554298

Strand: Direct

Name: nuoD

Synonym: MAP3204

Alternate gene names: 41409302

Gene position: 3552973-3554298 (Clockwise)

Preceding gene: 41409301

Following gene: 41409303

Centisome position: 73.56

GC content: 65.31

Gene sequence:

>1326_bases
ATGAGCACCACCACCGAATCGACGCACGACGGCGCCGGCGAGACTCTCGTGGTCGCGGGCGGCCAGGACTGGGACAAGGT
CGTCGAGGCTGCCCGCAGCGCCGACCCCGGCGAACGCATCGTCGTCAACATGGGACCCCAGCACCCGTCCACCCACGGGG
TGCTGCGGCTGATCCTGGAGATCGAGGGCGAAACGGTCACCGAGGCGCGTTGCGGAATCGGCTACCTGCACACCGGCATC
GAGAAGAACCTCGAATACCGGTACTGGACCCAGGGTGTCACGTTCGTGACCCGAATGGATTATCTCTCACCGTTTTTCAA
CGAGACCGCCTACTGCCTGGGCGTGGAGAAGCTGCTCGGCATCACCGACCAGATACCGGAGCGGGTCAACGTCATCCGGG
TGATGATGATGGAGCTCAACCGGATCTCCTCGCATCTGGTGGCCCTGGCCACCGGCGGCATGGAGCTGGGCGCGATGACG
CCGATGTTCGTCGGCTTCCGCGGCCGCGAAATCGTGCTCACCCTGTTCGAGTCGATCACCGGGCTGCGGATGAACAGCGC
CTACATCCGGCCCGGCGGCGTGGCCCAGGACCTGCCGCCGAATGCGAAAACCGAAATCGCCCAGGCGCTCGACCAGTTGC
GCCAACCGCTGCGCGAAATGGGCGACCTGCTCAACGAGAACGCCATCTGGAAGGCCCGCACCCAGGACATCGGCTACCTG
GACCTGACCGGCTGCATGGCGCTGGGCATCACGGGGCCGATCCTTCGCGCCACCGGGCTGCCGCACGATCTGCGCAAGAG
CGAACCGTACTGCGGTTATGAAAACTACGAATTCGACGTGATCACCGCCGACACGTGTGATGCTTACGGGCGCTACATGA
TTCGCGTCAAGGAGATGTGGGAGTCGATCAAGATCGTCGAGCAATGTCTGGACAAGTTGCAGCCGGGCCCCATCATGGTC
GAGAACGGAAAGATCGCCTGGCCCGCCGATTTGAAGGTCGGCCCGGACGGCCTGGGTAACTCGCCGGAGCACATCGCCAA
GATCATGGGCGGCTCGATGGAGGCCCTGATCCACCACTTCAAGCTGGTCACCGAGGGCATCCGGGTCCCGCCGGGCCAGG
TGTACACGGCGGTCGAATCGCCGCGCGGCGAGCTCGGCGTGCACATGGTCAGCGACGGCGGCACCCGCCCCTACCGGGTG
CACTACCGCGACCCGTCGTTCACCAATCTGCAGTCCGTCGCCGCGATGTGCGAGGGCGGCATGGTCGCCGACCTGATCAC
CGCGGTCGCCAGCATCGACCCGGTGATGGGCGGGGTGGACCGATGA

Upstream 100 bases:

>100_bases
ACGGGCATCCGCAGCGCAAGGACTACCCGCTCGGCGGGATCCCGGTCGAATACAAAGGCGCACAGATACCCCCGCCCGAC
GAGCGGAGAGCGTACAACTG

Downstream 100 bases:

>100_bases
CCGGCCCACAGGGGCAGCCGGTGTTCCTCCGGCTCGGCCCGCCGCCCGACGAGCCCAACGCGTTCGTGGTCGAGGGCGCG
CCCACGTCCTACCCGCCCGA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSTTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVTEARCGIGYLHTGI
EKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMT
PMFVGFRGREIVLTLFESITGLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYL
DLTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMWESIKIVEQCLDKLQPGPIMV
ENGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHFKLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRV
HYRDPSFTNLQSVAAMCEGGMVADLITAVASIDPVMGGVDR

Sequences:

>Translated_441_residues
MSTTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVTEARCGIGYLHTGI
EKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMT
PMFVGFRGREIVLTLFESITGLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYL
DLTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMWESIKIVEQCLDKLQPGPIMV
ENGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHFKLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRV
HYRDPSFTNLQSVAAMCEGGMVADLITAVASIDPVMGGVDR
>Mature_440_residues
STTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVTEARCGIGYLHTGIE
KNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMTP
MFVGFRGREIVLTLFESITGLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYLD
LTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMWESIKIVEQCLDKLQPGPIMVE
NGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHFKLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRVH
YRDPSFTNLQSVAAMCEGGMVADLITAVASIDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=43.8118811881188, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=43.4010152284264, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI145693162, Length=411, Percent_Identity=37.956204379562, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1789076, Length=403, Percent_Identity=28.0397022332506, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1788832, Length=404, Percent_Identity=26.980198019802, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17568379, Length=404, Percent_Identity=41.5841584158416, Blast_Score=344, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=40.8415841584158, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI221459469, Length=401, Percent_Identity=42.3940149625935, Blast_Score=351, Evalue=7e-97,
Organism=Drosophila melanogaster, GI24638644, Length=402, Percent_Identity=41.5422885572139, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_MYCA1 (A0QJV0)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_883188.1
- ProteinModelPortal:   A0QJV0
- SMR:   A0QJV0
- STRING:   A0QJV0
- EnsemblBacteria:   EBMYCT00000013321
- GeneID:   4529715
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_4036
- TIGR:   MAV_4036
- eggNOG:   COG0649
- GeneTree:   EBGT00050000016726
- HOGENOM:   HBG459705
- OMA:   LRMNHAF
- PhylomeDB:   A0QJV0
- ProtClustDB:   PRK06075
- BioCyc:   MAVI243243:MAV_4036-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 48359; Mature: 48228

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILE
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEE
IEGETVTEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLG
ECCCEEHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHEEHHHHHC
ITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMTPMFVGFRGREIVLTLFESIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHCCCCHHHCCCCCCHHHHHHHHHHH
GLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYL
CCEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEE
DLTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMW
EHHHHHHHCCCCHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ESIKIVEQCLDKLQPGPIMVENGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHF
HHHHHHHHHHHHCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
KLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGG
HHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCC
MVADLITAVASIDPVMGGVDR
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STTTESTHDGAGETLVVAGGQDWDKVVEAARSADPGERIVVNMGPQHPSTHGVLRLILE
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEE
IEGETVTEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLG
ECCCEEHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHEEHHHHHC
ITDQIPERVNVIRVMMMELNRISSHLVALATGGMELGAMTPMFVGFRGREIVLTLFESIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHCCCCHHHCCCCCCHHHHHHHHHHH
GLRMNSAYIRPGGVAQDLPPNAKTEIAQALDQLRQPLREMGDLLNENAIWKARTQDIGYL
CCEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEE
DLTGCMALGITGPILRATGLPHDLRKSEPYCGYENYEFDVITADTCDAYGRYMIRVKEMW
EHHHHHHHCCCCHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ESIKIVEQCLDKLQPGPIMVENGKIAWPADLKVGPDGLGNSPEHIAKIMGGSMEALIHHF
HHHHHHHHHHHHCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
KLVTEGIRVPPGQVYTAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGG
HHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCC
MVADLITAVASIDPVMGGVDR
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA