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The map label for this gene is yngG [H]

Identifier: 41409292

GI number: 41409292

Start: 3545491

End: 3546396

Strand: Direct

Name: yngG [H]

Synonym: MAP3194

Alternate gene names: 41409292

Gene position: 3545491-3546396 (Clockwise)

Preceding gene: 41409291

Following gene: 41409293

Centisome position: 73.41

GC content: 72.63

Gene sequence:

>906_bases
GTGAACACACATGTGGCCATCCGCGAGGTGGCGCTGCGCGACGGCCTGCAGATCGAGGCGCCGATCCCGTTGTCCGCCAA
GCTCGAACTGCTGGCCGCGGTGGCGGCCACCGGCGTGCGCGAGGTCGAGGCCACCGCGTTCGTCTCCCCGTCCAAGGTGC
CGTCGATGGCCGACGCCGCCGAGCTGGCCGCCCACCTGGCCGACTACCCCGACATCGAATTCTCCGCCCTGGTCGCCAGT
CCCAACGGCGCCAGGCGGGCGGTGGCCGCCGGGTTGCGCGCCATCGAATACGTGGTGGCCGCCGACGACACGTTCAGCGC
GGCCAACGTCGGGCGCACCAGCGCCGAGGCCACCGAACAGATCGGCGACATCGTCGCCATCGCCCACGACGGCCCGGGCC
CGCCGGTCACCGTCGAAGTCGTCATCGCCACCGCGTGGGACTCACCGTTCGAAGGCCCCACTCCCCCGCAGCGGGTGCTC
GACATCGCCGCCGCGGCCCGCGACCGCGGGGCCGACCGGCTGTCGATCGCCGACACCATCGGCACGGCGACCCCCGGCCG
GGTGAGTTCGCTGATCGCGCAACTGCTTCCGGTGATCGGTGACATGCCGCTGGGCGGTCATTTCCACAACACCCGCGGCT
GCGGGCTGGCCAGCGCGTACGCGGCGGTCGGCGCCGGGGTCACCCGGCTGGACGCGTCGGTCGGCGGGCTGGGTGGCTGC
CCGTTCGCGCCCGGGGCCACCGGCAACATCGCCACCGAGGACCTGGTGTACCTGCTCACCGACAGCGGATTCGACGTGGA
CGTCGACCTGCAGGCCGCCAGCGCCGCCGCCGGTGTCGCGAAAACACTTGTGGGGCATGATCTTCCCAGTGCCCTGCTGC
GCGCCGGGGACCGGCGGAGAAGTTGA

Upstream 100 bases:

>100_bases
CGGGTCCGGCGCGGCCGGGCCAGCACAACGACGAGGTGTACCGCGGGCTGCTGGGCAAGACCGCCGAGGAACTCGAGGAG
CTGCGGGCACAGGAGGTGCT

Downstream 100 bases:

>100_bases
GAGCGGGGCCCCTGATGCCTGCCGAACTGCTGACCGCCAAGGGCCGCCAGACCAGGCAGGCCATCGAGCAGGCCGCGCGC
AAGCTGTTCGCCGAGCGGGG

Product: hypothetical protein

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNTHVAIREVALRDGLQIEAPIPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAHLADYPDIEFSALVAS
PNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQIGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVL
DIAAAARDRGADRLSIADTIGTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGAGVTRLDASVGGLGGC
PFAPGATGNIATEDLVYLLTDSGFDVDVDLQAASAAAGVAKTLVGHDLPSALLRAGDRRRS

Sequences:

>Translated_301_residues
MNTHVAIREVALRDGLQIEAPIPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAHLADYPDIEFSALVAS
PNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQIGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVL
DIAAAARDRGADRLSIADTIGTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGAGVTRLDASVGGLGGC
PFAPGATGNIATEDLVYLLTDSGFDVDVDLQAASAAAGVAKTLVGHDLPSALLRAGDRRRS
>Mature_301_residues
MNTHVAIREVALRDGLQIEAPIPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAHLADYPDIEFSALVAS
PNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQIGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVL
DIAAAARDRGADRLSIADTIGTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGAGVTRLDASVGGLGGC
PFAPGATGNIATEDLVYLLTDSGFDVDVDLQAASAAAGVAKTLVGHDLPSALLRAGDRRRS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150427, Length=267, Percent_Identity=35.5805243445693, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI109150422, Length=267, Percent_Identity=35.5805243445693, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI62198232, Length=269, Percent_Identity=34.5724907063197, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI260654708, Length=102, Percent_Identity=44.1176470588235, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17510563, Length=284, Percent_Identity=33.4507042253521, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24582381, Length=294, Percent_Identity=35.7142857142857, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30466; Mature: 30466

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50991 PYR_CT ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTHVAIREVALRDGLQIEAPIPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAA
CCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHH
ELAAHLADYPDIEFSALVASPNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQ
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCHHHCCCCHHHHHHH
IGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVLDIAAAARDRGADRLSIADTI
HCCEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
GTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGAGVTRLDASVGGLGGC
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCC
PFAPGATGNIATEDLVYLLTDSGFDVDVDLQAASAAAGVAKTLVGHDLPSALLRAGDRRR
CCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
S
C
>Mature Secondary Structure
MNTHVAIREVALRDGLQIEAPIPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAA
CCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHEEECCCCCCCHHHHH
ELAAHLADYPDIEFSALVASPNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQ
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCHHHCCCCHHHHHHH
IGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVLDIAAAARDRGADRLSIADTI
HCCEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
GTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGAGVTRLDASVGGLGGC
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCC
PFAPGATGNIATEDLVYLLTDSGFDVDVDLQAASAAAGVAKTLVGHDLPSALLRAGDRRR
CCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]