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The map label for this gene is echA12 [H]

Identifier: 41409219

GI number: 41409219

Start: 3472011

End: 3472865

Strand: Direct

Name: echA12 [H]

Synonym: MAP3121

Alternate gene names: 41409219

Gene position: 3472011-3472865 (Clockwise)

Preceding gene: 41409217

Following gene: 41409220

Centisome position: 71.89

GC content: 72.63

Gene sequence:

>855_bases
CTGGATTCTCGACGCCGTCGACGACGTGATCGCCGGCGGCGGCATGGGCACCGCGACCATCATCGAGCGGGTGTGACGAT
GCCGAGCATGCTGGAGCTGGCCGCGCCGGGCGACGGGGTGCGGGTGCTGCGGCTGAATCGCCCGCACCGGCTCAATGCCA
TCGACGAGGCGATGCAGACCGAATTGCGGTTGGTGCTCGACGATTTGGCCGCCGACCACGCGGTACGCGCCGTGGTGCTG
ACCGGCGCCGGGCGGGGCTTCTGCGCGGGCATCGACATGCGTGACTTCGGGCCGTCGATGGTCAGGGCCGACGCGCCGGC
GCTGGAGCGGATGCGGTTTCAGGAGCGGATGGCCGCCCTCGCGGAGGCGGTGTGGGCACTGCCGCAACCCGTCATCGCGG
CGGTCAACGGGCCCTGCGTCGGCGCGGGACTGGCCCTGTGTCTGGCCGCCGACATCCGAATCTGCTCGGCGGCAGCGACT
TTCGCCAACGCGGCCATCCTGCTCGGGCTGTCCGGCGCCGAGATGGGCATGAGCTATCACCTGCCCCGCATCGTCGGGAC
CGGCGTCGCCGCCGACTGGATGCTCACCGGCCGTACCGTGTCGGCCGCCGAAGCCGACCGGCGCGGGCTGGTGAGCGAGG
TCGTCGAGCCGGACCGGCTGGCCGAGCGGGCGGTGGAGTTGGCGCGGCTCATCGCCGGGCACGCGCCGCTCGGCGCGCAG
CTGACCAAGCGCGCCCTGCAGGTCAACACCGACGCCGCGAGCCTGGCGTCGGCGATGGAGCTGGAGAACCGCAACCAGGT
GATCGCGCACGCAACCGACGAGGCGGCGGCGCGCCGGCAGATGTGGTCGCGGTGA

Upstream 100 bases:

>100_bases
CCGGCCAATTCGGGAGAAGACAGTTCTCGATAACCGAGAGACGATTTACGATCACTGGTGACCTGAGCGGTCCCTGACGA
TCGGAGTTCCCCATCGACGC

Downstream 100 bases:

>100_bases
ACCGTAACCCGGAGAGGACGGCAGATGTCGTGGGACTTTTCCACCGAACCCCAGTGGGCGCGGCAACTCGAATGGGTCGA
GGATTTCGTGCGCGAGGAGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MDSRRRRRRDRRRRHGHRDHHRAGVTMPSMLELAAPGDGVRVLRLNRPHRLNAIDEAMQTELRLVLDDLAADHAVRAVVL
TGAGRGFCAGIDMRDFGPSMVRADAPALERMRFQERMAALAEAVWALPQPVIAAVNGPCVGAGLALCLAADIRICSAAAT
FANAAILLGLSGAEMGMSYHLPRIVGTGVAADWMLTGRTVSAAEADRRGLVSEVVEPDRLAERAVELARLIAGHAPLGAQ
LTKRALQVNTDAASLASAMELENRNQVIAHATDEAAARRQMWSR

Sequences:

>Translated_284_residues
MDSRRRRRRDRRRRHGHRDHHRAGVTMPSMLELAAPGDGVRVLRLNRPHRLNAIDEAMQTELRLVLDDLAADHAVRAVVL
TGAGRGFCAGIDMRDFGPSMVRADAPALERMRFQERMAALAEAVWALPQPVIAAVNGPCVGAGLALCLAADIRICSAAAT
FANAAILLGLSGAEMGMSYHLPRIVGTGVAADWMLTGRTVSAAEADRRGLVSEVVEPDRLAERAVELARLIAGHAPLGAQ
LTKRALQVNTDAASLASAMELENRNQVIAHATDEAAARRQMWSR
>Mature_284_residues
MDSRRRRRRDRRRRHGHRDHHRAGVTMPSMLELAAPGDGVRVLRLNRPHRLNAIDEAMQTELRLVLDDLAADHAVRAVVL
TGAGRGFCAGIDMRDFGPSMVRADAPALERMRFQERMAALAEAVWALPQPVIAAVNGPCVGAGLALCLAADIRICSAAAT
FANAAILLGLSGAEMGMSYHLPRIVGTGVAADWMLTGRTVSAAEADRRGLVSEVVEPDRLAERAVELARLIAGHAPLGAQ
LTKRALQVNTDAASLASAMELENRNQVIAHATDEAAARRQMWSR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=242, Percent_Identity=31.404958677686, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI70995211, Length=221, Percent_Identity=33.0316742081448, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI20127408, Length=192, Percent_Identity=31.25, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45643119, Length=191, Percent_Identity=31.9371727748691, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260275230, Length=191, Percent_Identity=31.9371727748691, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260274832, Length=191, Percent_Identity=31.9371727748691, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI68989263, Length=237, Percent_Identity=28.6919831223629, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221136756, Length=269, Percent_Identity=25.2788104089219, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136753, Length=269, Percent_Identity=25.2788104089219, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221307494, Length=271, Percent_Identity=25.830258302583, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI116235487, Length=174, Percent_Identity=28.735632183908, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI31542718, Length=203, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=218, Percent_Identity=29.3577981651376, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1787660, Length=232, Percent_Identity=37.0689655172414, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787659, Length=216, Percent_Identity=36.1111111111111, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI221142681, Length=220, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788682, Length=211, Percent_Identity=32.2274881516588, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=27.8884462151394, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082183, Length=222, Percent_Identity=23.8738738738739, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540714, Length=234, Percent_Identity=32.4786324786325, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17536985, Length=220, Percent_Identity=32.7272727272727, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=31.640625, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=32.3383084577114, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17534483, Length=232, Percent_Identity=30.6034482758621, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=248, Percent_Identity=31.8548387096774, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=224, Percent_Identity=29.9107142857143, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=194, Percent_Identity=30.4123711340206, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=189, Percent_Identity=29.1005291005291, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=236, Percent_Identity=29.2372881355932, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=236, Percent_Identity=29.2372881355932, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=236, Percent_Identity=29.2372881355932, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=198, Percent_Identity=28.7878787878788, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=190, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19920382, Length=228, Percent_Identity=35.9649122807018, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=35.0597609561753, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=35.0597609561753, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24653139, Length=241, Percent_Identity=32.3651452282158, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357171, Length=200, Percent_Identity=28, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24654903, Length=182, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922422, Length=237, Percent_Identity=25.7383966244726, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650670, Length=234, Percent_Identity=26.4957264957265, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=183, Percent_Identity=28.4153005464481, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583077, Length=220, Percent_Identity=27.7272727272727, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583079, Length=220, Percent_Identity=27.7272727272727, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 30675; Mature: 30675

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSRRRRRRDRRRRHGHRDHHRAGVTMPSMLELAAPGDGVRVLRLNRPHRLNAIDEAMQT
CCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHH
ELRLVLDDLAADHAVRAVVLTGAGRGFCAGIDMRDFGPSMVRADAPALERMRFQERMAAL
HHHHHHHHHHHHHHHEEEEEECCCCCEEECCCHHHCCCHHHHCCCHHHHHHHHHHHHHHH
AEAVWALPQPVIAAVNGPCVGAGLALCLAADIRICSAAATFANAAILLGLSGAEMGMSYH
HHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCHHC
LPRIVGTGVAADWMLTGRTVSAAEADRRGLVSEVVEPDRLAERAVELARLIAGHAPLGAQ
CHHHHHCCCHHHHEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHH
LTKRALQVNTDAASLASAMELENRNQVIAHATDEAAARRQMWSR
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MDSRRRRRRDRRRRHGHRDHHRAGVTMPSMLELAAPGDGVRVLRLNRPHRLNAIDEAMQT
CCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHH
ELRLVLDDLAADHAVRAVVLTGAGRGFCAGIDMRDFGPSMVRADAPALERMRFQERMAAL
HHHHHHHHHHHHHHHEEEEEECCCCCEEECCCHHHCCCHHHHCCCHHHHHHHHHHHHHHH
AEAVWALPQPVIAAVNGPCVGAGLALCLAADIRICSAAATFANAAILLGLSGAEMGMSYH
HHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCHHC
LPRIVGTGVAADWMLTGRTVSAAEADRRGLVSEVVEPDRLAERAVELARLIAGHAPLGAQ
CHHHHHCCCHHHHEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHH
LTKRALQVNTDAASLASAMELENRNQVIAHATDEAAARRQMWSR
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]