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The map label for this gene is fabG2 [H]

Identifier: 41409214

GI number: 41409214

Start: 3464662

End: 3465420

Strand: Reverse

Name: fabG2 [H]

Synonym: MAP3116c

Alternate gene names: 41409214

Gene position: 3465420-3464662 (Counterclockwise)

Preceding gene: 41409218

Following gene: 41409213

Centisome position: 71.75

GC content: 69.43

Gene sequence:

>759_bases
ATGGAGATCAACGGGAAGAAAGCCGTCGTCGTCGGCGGTGCATCGGGAATGGGACGCGCCAGCGCCGAGCTGTTCGCGGC
GCGCGGCGCCGACGTCGCCATCCTCGACCGCGAGAGTTCCGACGGCAAGGCGGTGGCCGAGGGCATCGGCGCCGCGTTCT
ACCCCGTCGACGTCACCGACTTCGCCGGCACCGAGGAGACCCTGCAGAGCGCGGTCGACAAGCTGGGCGGCCTGCACGTC
ATCGTCACCACCGCCGGGGGCGGCATCGCCAAACGGACCCTGACCAAGAACGGCCCGCACGACCTCGAATCCTTCCAGTC
GGTGATCGACCTCAACCTCATCGCCACCTTCAACATCAGCCGGCTGGCCGCCGCGCACATGGCCAAGAACGAGCCCGAGG
ACGAGGAGCGCGGCGTCATCATCAACACCGCCTCCATCGCCGCCTTCGAGGGCCAGATCGGGCAGGTCGCCTACACCGCC
GCCAAGGCCGCCATCGCCGGGATGTGCCTGACCATGGCGCGTGACCTCGGCTCGGTGGGGGTGCGGGTGCTGGCGATCGC
CCCCAGCCTGTTCGCCACCGGGTTGACCCAGGGCATTCCCGACGAGTTCGCGACGCAGCTGACCAAGGACGCGGCCTTCC
CCAAGCGCCTCGGCCGTCCCGAGGAGTACGCGAAGCTGGCCCTGGCCATCGTGGACAACCCGATGCTCAACGGCCAGTGC
CTGCGGCTGGACGCCGGTCAGCGGTTCGCGCCCAAGTAG

Upstream 100 bases:

>100_bases
GCATGGCTCGGTGACAAGCGCCTGGAGCGGACACGCTAGCGTGCCTACGTAACGTTACAAATCGCATGGATTCTGACAAG
CCTGACAATGGGAGGTCCGG

Downstream 100 bases:

>100_bases
GCGCCCCCCGCCGGAACCCTCCTCGCATTAAGTACACTCTTTAGGCAGCCGCCCCGCTTCCCCTCGAAGCGGGGCAGGCA
CCCATCCCGGTACGGCGAGG

Product: hypothetical protein

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRESSDGKAVAEGIGAAFYPVDVTDFAGTEETLQSAVDKLGGLHV
IVTTAGGGIAKRTLTKNGPHDLESFQSVIDLNLIATFNISRLAAAHMAKNEPEDEERGVIINTASIAAFEGQIGQVAYTA
AKAAIAGMCLTMARDLGSVGVRVLAIAPSLFATGLTQGIPDEFATQLTKDAAFPKRLGRPEEYAKLALAIVDNPMLNGQC
LRLDAGQRFAPK

Sequences:

>Translated_252_residues
MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRESSDGKAVAEGIGAAFYPVDVTDFAGTEETLQSAVDKLGGLHV
IVTTAGGGIAKRTLTKNGPHDLESFQSVIDLNLIATFNISRLAAAHMAKNEPEDEERGVIINTASIAAFEGQIGQVAYTA
AKAAIAGMCLTMARDLGSVGVRVLAIAPSLFATGLTQGIPDEFATQLTKDAAFPKRLGRPEEYAKLALAIVDNPMLNGQC
LRLDAGQRFAPK
>Mature_252_residues
MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRESSDGKAVAEGIGAAFYPVDVTDFAGTEETLQSAVDKLGGLHV
IVTTAGGGIAKRTLTKNGPHDLESFQSVIDLNLIATFNISRLAAAHMAKNEPEDEERGVIINTASIAAFEGQIGQVAYTA
AKAAIAGMCLTMARDLGSVGVRVLAIAPSLFATGLTQGIPDEFATQLTKDAAFPKRLGRPEEYAKLALAIVDNPMLNGQC
LRLDAGQRFAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=47.0588235294118, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=45.2755905511811, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=29.3838862559242, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI59889578, Length=204, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=29.1428571428571, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4504505, Length=261, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI10190704, Length=235, Percent_Identity=28.5106382978723, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=30.2788844621514, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=30.4526748971193, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=30.078125, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=29.2490118577075, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=28.0632411067194, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=27.843137254902, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=26.5151515151515, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=26.1044176706827, Blast_Score=64, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=41.501976284585, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=29.5454545454545, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=27.7566539923954, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=28.1368821292776, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=27.8195488721804, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=26.9961977186312, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=236, Percent_Identity=32.2033898305085, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=28.7313432835821, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=28.5185185185185, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.7566539923954, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=25.8555133079848, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=208, Percent_Identity=28.3653846153846, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=27.7153558052434, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=27.5471698113208, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=26.615969581749, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=26.5384615384615, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=24.1379310344828, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=264, Percent_Identity=28.7878787878788, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=26.8199233716475, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=48.8188976377953, Blast_Score=233, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=28.5140562248996, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859837, Length=223, Percent_Identity=31.390134529148, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI23397609, Length=237, Percent_Identity=27.4261603375527, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24644339, Length=241, Percent_Identity=26.9709543568465, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=237, Percent_Identity=26.5822784810127, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357041, Length=233, Percent_Identity=26.1802575107296, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26142; Mature: 26142

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRESSDGKAVAEGIGAAFYPVDVTD
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCEEEEEECHH
FAGTEETLQSAVDKLGGLHVIVTTAGGGIAKRTLTKNGPHDLESFQSVIDLNLIATFNIS
CCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHEEEEECHH
RLAAAHMAKNEPEDEERGVIINTASIAAFEGQIGQVAYTAAKAAIAGMCLTMARDLGSVG
HHHHHHHHCCCCCHHHCCEEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
VRVLAIAPSLFATGLTQGIPDEFATQLTKDAAFPKRLGRPEEYAKLALAIVDNPMLNGQC
EEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCEE
LRLDAGQRFAPK
EEECCCCCCCCC
>Mature Secondary Structure
MEINGKKAVVVGGASGMGRASAELFAARGADVAILDRESSDGKAVAEGIGAAFYPVDVTD
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCEEEEEECHH
FAGTEETLQSAVDKLGGLHVIVTTAGGGIAKRTLTKNGPHDLESFQSVIDLNLIATFNIS
CCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHEEEEECHH
RLAAAHMAKNEPEDEERGVIINTASIAAFEGQIGQVAYTAAKAAIAGMCLTMARDLGSVG
HHHHHHHHCCCCCHHHCCEEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
VRVLAIAPSLFATGLTQGIPDEFATQLTKDAAFPKRLGRPEEYAKLALAIVDNPMLNGQC
EEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCEE
LRLDAGQRFAPK
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]