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The map label for this gene is iscS [H]

Identifier: 41409156

GI number: 41409156

Start: 3401720

End: 3402898

Strand: Reverse

Name: iscS [H]

Synonym: MAP3058c

Alternate gene names: 41409156

Gene position: 3402898-3401720 (Counterclockwise)

Preceding gene: 41409157

Following gene: 41409155

Centisome position: 70.46

GC content: 72.18

Gene sequence:

>1179_bases
ATGGTCTACCTGGATCACGCCGCCACCACCCCGATGCACCCCGCCGCCGTCGAGGCGATGACGGCTGTGCTCGGCACGGT
CGGCAACGCCTCCTCGCTGCACACCAGCGGCCGGGCGGCGCGGCGGCGCATCGAGGAGTCCCGCGAGCTGATCGCCGACA
AGCTGGGCGCGCGCCCCTCGGAGGTGATCTTCACCGCGGGCGGCACCGAGAGCGACAACCTGGCGGTCAAGGGCATCTAC
TGGGCCCGCCGCGACGCCGAGCCGCGGCACCGGCGCATCGTGACCAGCGAGGTGGAACACCACGCCGTGCTGGACTCGGT
GAACTGGCTCGTCGAACACGAAGGCGCCGAGGTGACCTGGCTGCCGACCGCCGCCGACGGCTCGGTGAGCCCCGCCGCAC
TGCGCGAGGTGCTCACCCGTCACGACGACGTCGCCCTGGTCTCGGTGATGTGGGCCAACAACGAGGTCGGCACCGTGCAG
CCAGTCGCCGAATTGGCTGCTGTCGCAGCGGAATTCGGTGTCCCGATGCACAGCGATGCGGTCCAGGCGGTGGGCCAGCT
GCCGGTCGACTTCACCGCCAGCGGGTTGTCGGCGATGAGCGTGACCGCGCACAAGTTCGGCGGCCCGCCGGCCGTGGGCG
CGCTGCTGCTGCGCCGCGACGTCGCGTGCGTGCCGCTGGCGCACGGCGGCGGGCAGGAACGCGACATCCGTTCGGGCACA
GCCGATGTCGCCGGGGCGGTCGGAATGGCGGCGGCGGCCCGGATCTCGGTCGACGGGCTGGAAACCAACAGCGCCCGGCT
GCGCGCGTTGCGGGATCGACTGGTCGACGGGGTGCTGGGCGGCATCGAGGACGTCACCCTCAACGGCGCCCGCGATCCGT
TGCGCCTTCCCGGCAACGCGCACTTCACCTTCCGCGGCTGCGAGGGCGATGCGCTGTTGATGTTGTTGGACGCCAACGGG
ATCGAGTGTTCAACCGGTTCGGCGTGCACCGCCGGTGTGGCGCAGCCGTCGCACGTGCTGGTGGCGATGGGCGTGGACCC
GGCCAGCGCCCGCGGCTCGTTGCGACTGTCGTTGGGGCACACCAGCATCGACGCGGACGTCGACGCCGTTCTGCGGGTGT
TGCCCGGGGCGGTGGAACGCGCTCGCCGGGCCGCGCTGGCCGCAGCGGGGGCTTCGTAA

Upstream 100 bases:

>100_bases
CTGCCAGTCCGCGGTGGGCGTGGCGGCGGCCCGGCGCGCTGGTCACGGGCGCGTGCTGGTGGCCTGAGCCCGCCGGCCGG
CCGGTATCGTGGGTCGGGTC

Downstream 100 bases:

>100_bases
GTGAGAGTGCTTGCCGCCATGAGCGGTGGCGTCGACTCGTCGGTCGCCGCCGCCCGGATGGTCGACGCCGGACACGACGT
GGTGGGCGTGCACCTGGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MVYLDHAATTPMHPAAVEAMTAVLGTVGNASSLHTSGRAARRRIEESRELIADKLGARPSEVIFTAGGTESDNLAVKGIY
WARRDAEPRHRRIVTSEVEHHAVLDSVNWLVEHEGAEVTWLPTAADGSVSPAALREVLTRHDDVALVSVMWANNEVGTVQ
PVAELAAVAAEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRRDVACVPLAHGGGQERDIRSGT
ADVAGAVGMAAAARISVDGLETNSARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALLMLLDANG
IECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSIDADVDAVLRVLPGAVERARRAALAAAGAS

Sequences:

>Translated_392_residues
MVYLDHAATTPMHPAAVEAMTAVLGTVGNASSLHTSGRAARRRIEESRELIADKLGARPSEVIFTAGGTESDNLAVKGIY
WARRDAEPRHRRIVTSEVEHHAVLDSVNWLVEHEGAEVTWLPTAADGSVSPAALREVLTRHDDVALVSVMWANNEVGTVQ
PVAELAAVAAEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRRDVACVPLAHGGGQERDIRSGT
ADVAGAVGMAAAARISVDGLETNSARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALLMLLDANG
IECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSIDADVDAVLRVLPGAVERARRAALAAAGAS
>Mature_392_residues
MVYLDHAATTPMHPAAVEAMTAVLGTVGNASSLHTSGRAARRRIEESRELIADKLGARPSEVIFTAGGTESDNLAVKGIY
WARRDAEPRHRRIVTSEVEHHAVLDSVNWLVEHEGAEVTWLPTAADGSVSPAALREVLTRHDDVALVSVMWANNEVGTVQ
PVAELAAVAAEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRRDVACVPLAHGGGQERDIRSGT
ADVAGAVGMAAAARISVDGLETNSARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALLMLLDANG
IECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSIDADVDAVLRVLPGAVERARRAALAAAGAS

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=37.5647668393782, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=34.2925659472422, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI48994898, Length=387, Percent_Identity=39.7932816537468, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=26.3959390862944, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789175, Length=409, Percent_Identity=27.1393643031785, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25143064, Length=386, Percent_Identity=37.0466321243523, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17533177, Length=317, Percent_Identity=30.9148264984227, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319831, Length=385, Percent_Identity=36.6233766233766, Blast_Score=237, Evalue=2e-63,
Organism=Drosophila melanogaster, GI20129463, Length=393, Percent_Identity=38.9312977099237, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40574; Mature: 40574

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYLDHAATTPMHPAAVEAMTAVLGTVGNASSLHTSGRAARRRIEESRELIADKLGARPS
CEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EVIFTAGGTESDNLAVKGIYWARRDAEPRHRRIVTSEVEHHAVLDSVNWLVEHEGAEVTW
CEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEE
LPTAADGSVSPAALREVLTRHDDVALVSVMWANNEVGTVQPVAELAAVAAEFGVPMHSDA
EECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHH
VQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRRDVACVPLAHGGGQERDIRSGT
HHHHHCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
ADVAGAVGMAAAARISVDGLETNSARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNA
HHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
HFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGH
EEEEECCCCCEEEEEEECCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECC
TSIDADVDAVLRVLPGAVERARRAALAAAGAS
CCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVYLDHAATTPMHPAAVEAMTAVLGTVGNASSLHTSGRAARRRIEESRELIADKLGARPS
CEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EVIFTAGGTESDNLAVKGIYWARRDAEPRHRRIVTSEVEHHAVLDSVNWLVEHEGAEVTW
CEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEE
LPTAADGSVSPAALREVLTRHDDVALVSVMWANNEVGTVQPVAELAAVAAEFGVPMHSDA
EECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHH
VQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRRDVACVPLAHGGGQERDIRSGT
HHHHHCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
ADVAGAVGMAAAARISVDGLETNSARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNA
HHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
HFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGH
EEEEECCCCCEEEEEEECCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECC
TSIDADVDAVLRVLPGAVERARRAALAAAGAS
CCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]