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The map label for this gene is serA

Identifier: 41409131

GI number: 41409131

Start: 3373753

End: 3375339

Strand: Reverse

Name: serA

Synonym: MAP3033c

Alternate gene names: 41409131

Gene position: 3375339-3373753 (Counterclockwise)

Preceding gene: 41409134

Following gene: 41409130

Centisome position: 69.89

GC content: 70.76

Gene sequence:

>1587_bases
GTGAATCTGCCAGTTGTACTCATTGCCGACAAACTCGCCGAATCAACCGTCGCGGCCTTGGGCGACCAGGTCGAGGTGCG
CTGGGTGGACGGGCCCGACCGGGAGAAGCTGCTGGCGGCCGTGCCGGAGGCCGACGCGCTGCTGGTGCGCTCGGCCACCA
CCGTCGACGCCGAGGTGCTGGCGGCCGCGCCCAAGCTGAAGATCGTCGCGCGCGCCGGGGTGGGCCTGGACAACGTCGAC
GTGGACGCCGCCACCGAGCGCGGGGTGCTGGTGGTCAACGCGCCGACCTCGAACATCCACAGCGCCGCCGAGCACGCGCT
GGCGCTGCTGCTGGCCGCCGCGCGCGAGATCCCGGCGGCCGACGCCTCGCTGCGCGAGCACACCTGGAAGCGGTCGTCCT
TCTCGGGCACCGAGATCTTCGGCAAGACGGTCGGCGTCGTCGGGCTGGGCCGGATCGGGCAGCTGGTTGCCCAGCGGCTC
AGCGCCTTCGGCACTCACCTCATCGCCTACGACCCGTACGTGTCGCCGGCCCGCGCCGCGCAGCTGGGTATCGAGCTGTT
GTCGTTGGACGAGCTGCTGGCCCGCGCCGACTTCATCTCCGTGCACCTGCCCAAGACCCCCGAGACGGCGGGGCTGATCG
ACAAGGACGCGCTGGCCAAGACCAAGCCGGGCGTCATCATCGTCAACGCCGCCCGCGGTGGCCTGGTCGACGAGGCGGCG
CTGGCCGACGCGGTGCGCAGCGGCCACGTGCGCGCGGCCGGCCTGGACGTGTTCTCCAAGGAGCCGTGCACCGACAGCCC
GCTGTTCGAGCTGCCGCAGGTGGTGGTCACGCCGCATCTGGGTGCGTCCACCACCGAGGCGCAGGATCGGGCGGGCACCG
ACGTCGCCGCGAGCGTAAAGCTCGCTCTGGCCGGGGAATTCGTTCCCGACGCGGTCAACGTCGCCGGGGGCACGGTGAAC
GAGGAGGTGGCGCCCTGGCTGGACCTGGTGCGCAAGCTCGGCCTGCTGGCCGCCACGCTGTCCGACGGCCCGCCGGTGTC
GCTGTCGGTGCAGGTGCGCGGCGAGTTGGCGTCGGAAGACGTTGAGGTGCTGAAACTTTCGGCTCTGCGGGTGTTGTTCT
CCGCCGTCGTGGAGGGGCCCGTGACGTTCGTCAACGCGCCGGCGCTGGCCGAAGAGCGCGGCGTCACCGCCGAGATCAGC
ACCGCCTCGGAAAGCCCCAACCACCGCAGCGTGGTCGACGTCCGCGCGGTGTCGCACGACGGCACTGCCGTCAACGTCGC
GGGAACGCTGTCCGGGCCGCAGCTGGTGGAGAAGATCGTGCAGATCAACGGCCGCAACTTCGACCTGCGCGCCCGCGGCA
TCAACCTGGTGATCAACTATGTCGACCAGCCCGGTGCGCTGGGCAAGATCGGCACCCTGTTGGGCTCGGCCGGGGTGAAC
ATCCAAGCCGCGCAGCTGTCCGAGGACGCCGAGGGCCCAGGCGCGACGATTCTGCTGCGGCTGGATCAAGACGTGCCGGC
CGATGTGCGGTCGGCCATCGGCGCGGCGGTCGGCGCGAACAAGCTTGAGGTGGTTGATCTCTCGTGA

Upstream 100 bases:

>100_bases
AGGCCGGCCCGGGCGCAGATGAGCGCAGCGGTCAGCCCGTTGGGTCCGCTGCCGACGATGGTGACGTCCACCCGTCAATT
ACAGCCGATAGGCTGGCCGG

Downstream 100 bases:

>100_bases
ACCGCCCCGACGACGATGCAGAGCGTAGCGATGGGGAGGAGCGGCGCCGATGAAACTCGCGGTGATCGGCGGCGACGGGA
TCGGCCCGGAGGTGACGGCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVD
VDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRL
SAFGTHLIAYDPYVSPARAAQLGIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAA
LADAVRSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPDAVNVAGGTVN
EEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASEDVEVLKLSALRVLFSAVVEGPVTFVNAPALAEERGVTAEIS
TASESPNHRSVVDVRAVSHDGTAVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVN
IQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS

Sequences:

>Translated_528_residues
MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVD
VDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRL
SAFGTHLIAYDPYVSPARAAQLGIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAA
LADAVRSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPDAVNVAGGTVN
EEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASEDVEVLKLSALRVLFSAVVEGPVTFVNAPALAEERGVTAEIS
TASESPNHRSVVDVRAVSHDGTAVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVN
IQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS
>Mature_528_residues
MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVD
VDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRL
SAFGTHLIAYDPYVSPARAAQLGIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAA
LADAVRSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPDAVNVAGGTVN
EEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASEDVEVLKLSALRVLFSAVVEGPVTFVNAPALAEERGVTAEIS
TASESPNHRSVVDVRAVSHDGTAVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVN
IQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=412, Percent_Identity=39.5631067961165, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI61743967, Length=305, Percent_Identity=32.7868852459016, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557497, Length=305, Percent_Identity=32.7868852459016, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI145580578, Length=322, Percent_Identity=32.2981366459627, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4557499, Length=322, Percent_Identity=32.2981366459627, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=35.3790613718412, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI145580575, Length=306, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1789279, Length=272, Percent_Identity=34.9264705882353, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=36.1370716510903, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=37.7551020408163, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788660, Length=271, Percent_Identity=33.5793357933579, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081824, Length=303, Percent_Identity=28.0528052805281, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=45.5445544554455, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI25147481, Length=345, Percent_Identity=32.1739130434783, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=292, Percent_Identity=33.9041095890411, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322116, Length=292, Percent_Identity=32.1917808219178, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324055, Length=259, Percent_Identity=35.1351351351351, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=29.520295202952, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=30.6818181818182, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=33.5570469798658, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=26.5, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921140, Length=327, Percent_Identity=43.1192660550459, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=37.6344086021505, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646446, Length=298, Percent_Identity=34.8993288590604, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646448, Length=298, Percent_Identity=34.8993288590604, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646452, Length=298, Percent_Identity=34.8993288590604, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646450, Length=298, Percent_Identity=34.8993288590604, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI62472511, Length=308, Percent_Identity=34.7402597402597, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=31.4285714285714, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574286, Length=300, Percent_Identity=32, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45551003, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 54509; Mature: 54509

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVL
CCCCEEEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHEEECCCCCEEEEECCCCCCHHHH
AAAPKLKIVARAGVGLDNVDVDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAA
HCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
DASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRLSAFGTHLIAYDPYVSPARAA
CCHHHHHHCCCCCCCCCHHHHHHHCCEEHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
QLGIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAA
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCHHHH
LADAVRSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVK
HHHHHHCCCEEEECCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCCCHHHEEE
LALAGEFVPDAVNVAGGTVNEEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASED
EEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCH
VEVLKLSALRVLFSAVVEGPVTFVNAPALAEERGVTAEISTASESPNHRSVVDVRAVSHD
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCEEEEECCCCCCCCCCEEEEEEECCC
GTAVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVN
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCCHHHHHHHHCCCCE
IQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS
EEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVL
CCCCEEEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHEEECCCCCEEEEECCCCCCHHHH
AAAPKLKIVARAGVGLDNVDVDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAA
HCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
DASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRLSAFGTHLIAYDPYVSPARAA
CCHHHHHHCCCCCCCCCHHHHHHHCCEEHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
QLGIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAA
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCHHHH
LADAVRSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVK
HHHHHHCCCEEEECCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCCCHHHEEE
LALAGEFVPDAVNVAGGTVNEEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASED
EEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCH
VEVLKLSALRVLFSAVVEGPVTFVNAPALAEERGVTAEISTASESPNHRSVVDVRAVSHD
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCEEEEECCCCCCCCCCEEEEEEECCC
GTAVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVN
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCCHHHHHHHHCCCCE
IQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS
EEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]