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The map label for this gene is cofC

Identifier: 41409119

GI number: 41409119

Start: 3360303

End: 3360965

Strand: Direct

Name: cofC

Synonym: MAP3021

Alternate gene names: 41409119

Gene position: 3360303-3360965 (Clockwise)

Preceding gene: 41409116

Following gene: 41409120

Centisome position: 69.57

GC content: 73.76

Gene sequence:

>663_bases
ATGAGCGGCAAACGAGCCGACGGCGGGCACGACGGTGCGGGCGATGTCGCCCTGATCATTGCGGTCAAGAGGCTGGCCGC
GGCCAAGACCAGGCTGGCCCCGGTGTTCTCGGCGCGCACCCGCGAAAGCGTGGTGCTGGCCATGTTGACCGACACCCTGA
CCGCCGCCACACGGGTCCCGTCGCTGGGTTCGATCACCGTGATCACGCCCGACGAGGCCGCCGCGGCGGCGGCCGCCGGG
CTGGGCGCCGACGTGCTGGCCGACCCGACCCCGGAGGGGCATCCGGATCCGCTCAACAACGCCATCGCCACCGCGGAGCG
CGCGGTGAGCGGTTCCTTTACCAATATCGTTGCGCTGCAAGGAGATCTGCCGGCGCTGCAGTCCCAGGAGCTGGCCGAGG
CGGTGGCCGCCGCGCGTGCGCACCGGCGCAGCTTCGTCGCCGACCGGCTGGCCACCGGCACCGCGGCGCTGTTCGCGTTC
GGCACCCGGCTCGATCCCCGGTTCGGCTCCGATTCGTCGGCGCGGCACCGCAGTTCGGGCGCGATCGAGCTGACCGGCGC
CTGGCCCGGCCTGCGCTGTGACGTCGATACCCCCACCGATCTAGCCGCCGCCCGCCGCCTCGGGGTGGGGGCCGCGACGG
CCCGGGCCATCGCCGCGCATTGA

Upstream 100 bases:

>100_bases
TGTAGCTCACGCGGCACTTGCAGCCGCTACACCCTAGATCAGCGGCCGACCGTGCGTCACGCAAGCCGGCTGCGCGCCGG
CGCTGGCAGGATGACATCTC

Downstream 100 bases:

>100_bases
TTTTCGCTCACCGCGGCCGAATCTGTCCGGCCGGTGAACGGCGGCCCAACGGCGAATGGATGTCCCGCGGGCGCTAGCAG
CAGCCGCGCGTGATGCGCCA

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSGKRADGGHDGAGDVALIIAVKRLAAAKTRLAPVFSARTRESVVLAMLTDTLTAATRVPSLGSITVITPDEAAAAAAAG
LGADVLADPTPEGHPDPLNNAIATAERAVSGSFTNIVALQGDLPALQSQELAEAVAAARAHRRSFVADRLATGTAALFAF
GTRLDPRFGSDSSARHRSSGAIELTGAWPGLRCDVDTPTDLAAARRLGVGAATARAIAAH

Sequences:

>Translated_220_residues
MSGKRADGGHDGAGDVALIIAVKRLAAAKTRLAPVFSARTRESVVLAMLTDTLTAATRVPSLGSITVITPDEAAAAAAAG
LGADVLADPTPEGHPDPLNNAIATAERAVSGSFTNIVALQGDLPALQSQELAEAVAAARAHRRSFVADRLATGTAALFAF
GTRLDPRFGSDSSARHRSSGAIELTGAWPGLRCDVDTPTDLAAARRLGVGAATARAIAAH
>Mature_219_residues
SGKRADGGHDGAGDVALIIAVKRLAAAKTRLAPVFSARTRESVVLAMLTDTLTAATRVPSLGSITVITPDEAAAAAAAGL
GADVLADPTPEGHPDPLNNAIATAERAVSGSFTNIVALQGDLPALQSQELAEAVAAARAHRRSFVADRLATGTAALFAFG
TRLDPRFGSDSSARHRSSGAIELTGAWPGLRCDVDTPTDLAAARRLGVGAATARAIAAH

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_MYCPA (Q73VJ2)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961955.1
- ProteinModelPortal:   Q73VJ2
- SMR:   Q73VJ2
- EnsemblBacteria:   EBMYCT00000040497
- GeneID:   2718041
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3021
- NMPDR:   fig|262316.1.peg.3021
- GeneTree:   EBGT00050000017164
- HOGENOM:   HBG699055
- OMA:   LNADLPA
- ProtClustDB:   CLSK792205
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 22262; Mature: 22131

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKRADGGHDGAGDVALIIAVKRLAAAKTRLAPVFSARTRESVVLAMLTDTLTAATRVP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
SLGSITVITPDEAAAAAAAGLGADVLADPTPEGHPDPLNNAIATAERAVSGSFTNIVALQ
CCCEEEEECCCHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
GDLPALQSQELAEAVAAARAHRRSFVADRLATGTAALFAFGTRLDPRFGSDSSARHRSSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
AIELTGAWPGLRCDVDTPTDLAAARRLGVGAATARAIAAH
CEEEEECCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
SGKRADGGHDGAGDVALIIAVKRLAAAKTRLAPVFSARTRESVVLAMLTDTLTAATRVP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
SLGSITVITPDEAAAAAAAGLGADVLADPTPEGHPDPLNNAIATAERAVSGSFTNIVALQ
CCCEEEEECCCHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
GDLPALQSQELAEAVAAARAHRRSFVADRLATGTAALFAFGTRLDPRFGSDSSARHRSSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
AIELTGAWPGLRCDVDTPTDLAAARRLGVGAATARAIAAH
CEEEEECCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA