| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is yqhE [C]
Identifier: 41409105
GI number: 41409105
Start: 3344071
End: 3344916
Strand: Direct
Name: yqhE [C]
Synonym: MAP3007
Alternate gene names: 41409105
Gene position: 3344071-3344916 (Clockwise)
Preceding gene: 41409099
Following gene: 41409112
Centisome position: 69.24
GC content: 67.49
Gene sequence:
>846_bases TTGACTGGCGAGTCGGGCTCCGCCGCACCCTCGATTGCTCTCAACGACGAAAACACGATGCCGGTGCTGGGCCTCGGTGT CGCGGAGTTGTCGGATGACGAGACCGAACGCGCGGTGTCGGCGGCGCTGGAGGTCGGCTGCCGGCTCATCGACACCGCCG CGGCCTACGGCAACGAGGCCGCCGTCGGGCGCGCCATCGCCGCCTCGGGGATCCCGCGCGCCGAGCTGTTCGTCACCACC AAGCTGGCCACCTCCGACCAGGGCTTCAAAGGGGCGATGGACGCCTGCGAGGCCAGCCTGGAGCGGCTCGGGCTGGACTA CGTCGACCTGTACCTGATTCACTGGCCGGCCCCCGCGCTGGGCACCTACGTGAACTCCTTCGGCGGCATGATCCAGTCCC GCGGCAACGGCCACGCCCGCTCGATCGGCGTCTCCAACTTCACCGAGGAGTACTTGACGACGGTCATCGACCTCACGTTC GTCACCCCGGCGGTCAACCAGATCGAGCTGCACCCGCTGCTCAACCAGGAAGCGCTGCGCAAGACCAACGCCGAGCACAA CGTGGTCACCCAGTCCTATACGCCGCTGGCGCTGGGCAAGCTGAACGACCACCCGACGGTGAACTCGGTGGCCGCCGAAT ACGGCAAGACCGCGTCGCAGGTGCTGCTGCGGTGGAACCTGCAGTTGAGCAACGCGGTGATCTTCCGGTCGGCCAACGCC GAGCACATCGCCAGCGACTTCGACGTGTTCGACTTCGAGCTGGCCGCCGAGCACATGGACGCCATCAACGCGCTCAACGA CGGCACCCGGCTGCGCCCGGACCCAGACACCTACGAGGGCTCCTAA
Upstream 100 bases:
>100_bases GATTTCGATTTCGGCGCCGAAACGGCGTTGACCTCCTCGCGCGATGACGGCCCCCGGCTCGATGCACACGAACGTTTGAC TTCACAGGCAGGTGAATGAA
Downstream 100 bases:
>100_bases CCGCTACCCCGCGGGGCAGGTGGCCGCGGCCTGACGCAGCACACCGGTGGACGCCTGGTCCACCGGCAGCGCATAGCCGC GCAGCACCGCGATGAACTGC
Product: hypothetical protein
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 281; Mature: 280
Protein sequence:
>281_residues MTGESGSAAPSIALNDENTMPVLGLGVAELSDDETERAVSAALEVGCRLIDTAAAYGNEAAVGRAIAASGIPRAELFVTT KLATSDQGFKGAMDACEASLERLGLDYVDLYLIHWPAPALGTYVNSFGGMIQSRGNGHARSIGVSNFTEEYLTTVIDLTF VTPAVNQIELHPLLNQEALRKTNAEHNVVTQSYTPLALGKLNDHPTVNSVAAEYGKTASQVLLRWNLQLSNAVIFRSANA EHIASDFDVFDFELAAEHMDAINALNDGTRLRPDPDTYEGS
Sequences:
>Translated_281_residues MTGESGSAAPSIALNDENTMPVLGLGVAELSDDETERAVSAALEVGCRLIDTAAAYGNEAAVGRAIAASGIPRAELFVTT KLATSDQGFKGAMDACEASLERLGLDYVDLYLIHWPAPALGTYVNSFGGMIQSRGNGHARSIGVSNFTEEYLTTVIDLTF VTPAVNQIELHPLLNQEALRKTNAEHNVVTQSYTPLALGKLNDHPTVNSVAAEYGKTASQVLLRWNLQLSNAVIFRSANA EHIASDFDVFDFELAAEHMDAINALNDGTRLRPDPDTYEGS >Mature_280_residues TGESGSAAPSIALNDENTMPVLGLGVAELSDDETERAVSAALEVGCRLIDTAAAYGNEAAVGRAIAASGIPRAELFVTTK LATSDQGFKGAMDACEASLERLGLDYVDLYLIHWPAPALGTYVNSFGGMIQSRGNGHARSIGVSNFTEEYLTTVIDLTFV TPAVNQIELHPLLNQEALRKTNAEHNVVTQSYTPLALGKLNDHPTVNSVAAEYGKTASQVLLRWNLQLSNAVIFRSANAE HIASDFDVFDFELAAEHMDAINALNDGTRLRPDPDTYEGS
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=32.0945945945946, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=32.0945945945946, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI310109922, Length=287, Percent_Identity=34.4947735191638, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI310109920, Length=305, Percent_Identity=32.7868852459016, Blast_Score=141, Evalue=5e-34, Organism=Homo sapiens, GI45446745, Length=305, Percent_Identity=32.7868852459016, Blast_Score=141, Evalue=6e-34, Organism=Homo sapiens, GI4503285, Length=305, Percent_Identity=32.7868852459016, Blast_Score=141, Evalue=6e-34, Organism=Homo sapiens, GI5453543, Length=305, Percent_Identity=32.7868852459016, Blast_Score=141, Evalue=8e-34, Organism=Homo sapiens, GI5174695, Length=304, Percent_Identity=31.9078947368421, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=30.2721088435374, Blast_Score=137, Evalue=1e-32, Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=31.3725490196078, Blast_Score=136, Evalue=2e-32, Organism=Homo sapiens, GI4502049, Length=298, Percent_Identity=33.2214765100671, Blast_Score=135, Evalue=4e-32, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=31.5436241610738, Blast_Score=132, Evalue=3e-31, Organism=Homo sapiens, GI24497583, Length=301, Percent_Identity=31.2292358803987, Blast_Score=130, Evalue=1e-30, Organism=Homo sapiens, GI291291012, Length=272, Percent_Identity=29.7794117647059, Blast_Score=121, Evalue=9e-28, Organism=Homo sapiens, GI300116271, Length=285, Percent_Identity=30.8771929824561, Blast_Score=120, Evalue=1e-27, Organism=Homo sapiens, GI300116273, Length=282, Percent_Identity=30.8510638297872, Blast_Score=117, Evalue=8e-27, Organism=Homo sapiens, GI207028673, Length=118, Percent_Identity=41.5254237288136, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=41.8803418803419, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI310109924, Length=157, Percent_Identity=31.2101910828025, Blast_Score=80, Evalue=1e-15, Organism=Escherichia coli, GI87082198, Length=271, Percent_Identity=46.8634686346863, Blast_Score=251, Evalue=4e-68, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=37.7952755905512, Blast_Score=160, Evalue=1e-40, Organism=Escherichia coli, GI1788081, Length=273, Percent_Identity=28.2051282051282, Blast_Score=97, Evalue=2e-21, Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=4e-42, Organism=Caenorhabditis elegans, GI17552492, Length=276, Percent_Identity=34.0579710144928, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=32.3432343234323, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=31.6326530612245, Blast_Score=139, Evalue=2e-33, Organism=Caenorhabditis elegans, GI17564128, Length=299, Percent_Identity=31.1036789297659, Blast_Score=138, Evalue=4e-33, Organism=Caenorhabditis elegans, GI17561298, Length=277, Percent_Identity=29.9638989169675, Blast_Score=134, Evalue=6e-32, Organism=Caenorhabditis elegans, GI17566692, Length=291, Percent_Identity=30.9278350515464, Blast_Score=130, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17537079, Length=301, Percent_Identity=27.5747508305648, Blast_Score=124, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17550248, Length=301, Percent_Identity=32.890365448505, Blast_Score=121, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17538386, Length=273, Percent_Identity=28.5714285714286, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=29.3040293040293, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562292, Length=279, Percent_Identity=27.2401433691756, Blast_Score=104, Evalue=5e-23, Organism=Saccharomyces cerevisiae, GI6320576, Length=280, Percent_Identity=34.6428571428571, Blast_Score=160, Evalue=3e-40, Organism=Saccharomyces cerevisiae, GI6324694, Length=285, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=5e-37, Organism=Saccharomyces cerevisiae, GI6319625, Length=294, Percent_Identity=34.6938775510204, Blast_Score=128, Evalue=1e-30, Organism=Saccharomyces cerevisiae, GI6322556, Length=270, Percent_Identity=28.8888888888889, Blast_Score=125, Evalue=7e-30, Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=29.4326241134752, Blast_Score=122, Evalue=7e-29, Organism=Saccharomyces cerevisiae, GI6321896, Length=315, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=9e-28, Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=36.1486486486487, Blast_Score=175, Evalue=4e-44, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=35.3333333333333, Blast_Score=163, Evalue=1e-40, Organism=Drosophila melanogaster, GI24657054, Length=300, Percent_Identity=34.6666666666667, Blast_Score=163, Evalue=2e-40, Organism=Drosophila melanogaster, GI45553081, Length=293, Percent_Identity=34.4709897610922, Blast_Score=162, Evalue=2e-40, Organism=Drosophila melanogaster, GI24662789, Length=299, Percent_Identity=33.1103678929766, Blast_Score=158, Evalue=4e-39, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=32.1875, Blast_Score=158, Evalue=5e-39, Organism=Drosophila melanogaster, GI20129731, Length=292, Percent_Identity=36.3013698630137, Blast_Score=157, Evalue=7e-39, Organism=Drosophila melanogaster, GI21356425, Length=300, Percent_Identity=33, Blast_Score=152, Evalue=2e-37, Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=32.6848249027237, Blast_Score=130, Evalue=8e-31, Organism=Drosophila melanogaster, GI24662785, Length=300, Percent_Identity=32.6666666666667, Blast_Score=120, Evalue=1e-27, Organism=Drosophila melanogaster, GI24662781, Length=301, Percent_Identity=31.8936877076412, Blast_Score=119, Evalue=3e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 30014; Mature: 29882
Theoretical pI: Translated: 4.28; Mature: 4.28
Prosite motif: PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTGESGSAAPSIALNDENTMPVLGLGVAELSDDETERAVSAALEVGCRLIDTAAAYGNEA CCCCCCCCCCEEEECCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH AVGRAIAASGIPRAELFVTTKLATSDQGFKGAMDACEASLERLGLDYVDLYLIHWPAPAL HHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHH GTYVNSFGGMIQSRGNGHARSIGVSNFTEEYLTTVIDLTFVTPAVNQIELHPLLNQEALR HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH KTNAEHNVVTQSYTPLALGKLNDHPTVNSVAAEYGKTASQVLLRWNLQLSNAVIFRSANA HCCCCCCEEECCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHEECEEECCEEEEECCCH EHIASDFDVFDFELAAEHMDAINALNDGTRLRPDPDTYEGS HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC >Mature Secondary Structure TGESGSAAPSIALNDENTMPVLGLGVAELSDDETERAVSAALEVGCRLIDTAAAYGNEA CCCCCCCCCEEEECCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH AVGRAIAASGIPRAELFVTTKLATSDQGFKGAMDACEASLERLGLDYVDLYLIHWPAPAL HHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHH GTYVNSFGGMIQSRGNGHARSIGVSNFTEEYLTTVIDLTFVTPAVNQIELHPLLNQEALR HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH KTNAEHNVVTQSYTPLALGKLNDHPTVNSVAAEYGKTASQVLLRWNLQLSNAVIFRSANA HCCCCCCEEECCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHEECEEECCEEEEECCCH EHIASDFDVFDFELAAEHMDAINALNDGTRLRPDPDTYEGS HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA