| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is cysG2
Identifier: 41409014
GI number: 41409014
Start: 3248085
End: 3249290
Strand: Reverse
Name: cysG2
Synonym: MAP2916c
Alternate gene names: 41409014
Gene position: 3249290-3248085 (Counterclockwise)
Preceding gene: 41409015
Following gene: 41409013
Centisome position: 67.28
GC content: 69.82
Gene sequence:
>1206_bases GTGACCGAGAGCGCCTACCTGGTGGGGCTGCGGCTGACCGGCAAGAAGGTGGTCGTGGTCGGCGGCGGCACCGTCGCCCA GCGCCGGCTGCCGTTGCTGATCGCCAGCGGCGCGGACGTCCACGTCATCTCCCGCAGCGCCACCCGATCGGTCGAGGCGA TGACCGGAATCACCCTGCAATTGCGCGAATACCGCGACGGCGACCTCGACGGCGCCTGGTACGCGATCGCGGCCACCGAC GACCCGCGGGTCAACGAGGCCGTGGTCGCCGAGGCCGAACGCCGCCGCATCTTCTGCGTCCGGGCGGACGTCGCCGTGGC GGGGACCGCGGTCACCCCAGCGTCTTTCAGCTATGCCGGGTTGTCGGTGGGCGTGCTGGCCGGCGGCGAGCACCGCCGCT CGGCGGCGATCCGCTCGGCCATCCGGGAGGCGCTGCAGACCGGGGTCATCACGCCGGAAGGCCCGGTGGGCTCCGACGCC GTCAAGGGCGGGGTGGCGCTGATCGGCGGCGGCCCCGGCGACCCCGAACTGATCACGGTGCGCGGCCGGCGGCTGCTGGC CCAGGCCGACGTCGTGGTGGCCGACCGGCTCGCCCCGCCCGAACTGCTCGCCGAGCTGCCCCCGCACGTGGAGGTGATCG ACGCCGCCAAGATTCCCTACGGCCGGGCCATGGCCCAGGACGCCATCAACGACGTCATGATCGAACGCGCCCGCGCCGGA AGCTTCGTGGTGCGCCTCAAAGGCGGGGACCCGTTCGTCTTCGCCCGCGGCTACGAGGAGGTGCTGGCGTGCGCCGACGC TGGGATTCCGGTCACCGTCGTCCCGGGTGTGACGAGTGCCATAGGAGTGCCCGCATTGGCGGGCGTCCCGGTCACCCATC GGGCGGTAAATCACGAATTCGTGGTGGTCAGCGGGCATCTCCCACCCGGTCATCCCGAATCGTTAGTGAATTGGGATGCA CTGGCCGCATTGACCGGCACAATTGTTTTGCTGATGGCGGTCGAACGTATCGAACTTTTCGCCGAGGCCCTGCTAAAGGG CGGACGACCAGCGGATACGCCGGTGCTGGTGGTTCAGCACGGGACGACGGCGGCGCAACACACTTTGCGGGCCACCCTGG CCGACACGCCCGAAAAGATTCGTGCCGAAGGTATCCGACCTCCCGCGATCATCGTGATCGGCGCGGTGGCGGCTTTCGGG GTTTAA
Upstream 100 bases:
>100_bases CGCGCCCGCGGCGGTGGCCCGCTTCGTCGGGTGCGCGCTGGCCGCTCGCGCCGACCCGGGCAGGACGCGGGCCCACCCCG GCAACCACTAGGCTTGCCGG
Downstream 100 bases:
>100_bases ACGGTTCTTAAGATTACTGTAAGGTAACCCTTTATGACGGCTCTCAACGACTCAGAGCGCGCGGTCCAGAACTGGACATC TGCACGCCCCGATCGTCCGG
Product: CysG2
Products: NA
Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]
Number of amino acids: Translated: 401; Mature: 400
Protein sequence:
>401_residues MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQLREYRDGDLDGAWYAIAATD DPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDA VKGGVALIGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEFVVVSGHLPPGHPESLVNWDA LAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQHGTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAVAAFG V
Sequences:
>Translated_401_residues MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQLREYRDGDLDGAWYAIAATD DPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDA VKGGVALIGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEFVVVSGHLPPGHPESLVNWDA LAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQHGTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAVAAFG V >Mature_400_residues TESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQLREYRDGDLDGAWYAIAATDD PRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDAV KGGVALIGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAGS FVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEFVVVSGHLPPGHPESLVNWDAL AALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQHGTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAVAAFGV
Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si
COG id: COG0007
COG function: function code H; Uroporphyrinogen-III methylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the precorrin methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1789768, Length=441, Percent_Identity=30.6122448979592, Blast_Score=190, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6322922, Length=266, Percent_Identity=31.5789473684211, Blast_Score=127, Evalue=3e-30,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000878 - InterPro: IPR014777 - InterPro: IPR014776 - InterPro: IPR006366 - InterPro: IPR016040 - InterPro: IPR019478 - InterPro: IPR006367 - InterPro: IPR003043 [H]
Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]
EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]
Molecular weight: Translated: 41572; Mature: 41441
Theoretical pI: Translated: 6.61; Mature: 6.61
Prosite motif: PS00213 LIPOCALIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQ CCCCEEEEEEEECCCEEEEECCCCCHHCCCCEEEECCCCEEEEECCHHCCHHHHHCEEEE LREYRDGDLDGAWYAIAATDDPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAG EEECCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECEEEECCEECCCCCCCCC LSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDAVKGGVALIGGGPGDPELITV EEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEE RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG CCCEEEECCCEEEECCCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEF CEEEEEECCCCEEEECCHHHHHHHHCCCCCEEECCCCCHHHCCCHHCCCCCCCEECCCEE VVVSGHLPPGHPESLVNWDALAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQH EEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC GTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAVAAFGV CCHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECHHHHCC >Mature Secondary Structure TESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQ CCCEEEEEEEECCCEEEEECCCCCHHCCCCEEEECCCCEEEEECCHHCCHHHHHCEEEE LREYRDGDLDGAWYAIAATDDPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAG EEECCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEECEEEECCEECCCCCCCCC LSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDAVKGGVALIGGGPGDPELITV EEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEE RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG CCCEEEECCCEEEECCCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEF CEEEEEECCCCEEEECCHHHHHHHHCCCCCEEECCCCCHHHCCCHHCCCCCCCEECCCEE VVVSGHLPPGHPESLVNWDALAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQH EEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC GTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAVAAFGV CCHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA