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The map label for this gene is echA16_2

Identifier: 41409002

GI number: 41409002

Start: 3234183

End: 3234932

Strand: Direct

Name: echA16_2

Synonym: MAP2904

Alternate gene names: 41409002

Gene position: 3234183-3234932 (Clockwise)

Preceding gene: 41409000

Following gene: 41409009

Centisome position: 66.96

GC content: 73.07

Gene sequence:

>750_bases
ATGACCGACGAGATCCTGCTGAGCAACACCGAGGAGCGGGTGCGCACCCTCACCCTCAACCGGCCCCAGGCCCGCAACGC
GCTGTCCGCGGCCTTGCGGGACCGCTTCTTCGGCGCCCTGGCCGACGCCGAGACGGACGACGACGTGGACGTCGTCATCA
TCACCGGCGCCGATCCGGTGTTCTGCGCGGGGCTGGATCTCAAGGAGCTGGGCGGCTCGTCGGCGCTGCCGGACATCTCG
CCGCGCTGGCCGGCGCTGACCAAGCCGGTGATCGGCGCCATCAACGGCGCCGCGGTCACCGGTGGGCTGGAGCTGGCGCT
GTATTGCGACATCCTGATCGCCTCGGAGAACGCCCGCTTCGCCGACACGCACGCCCGGGTCGGCCTGCTGCCCACCTGGG
GGCTGAGCGTGCGGCTGCCGCAGAAGGTGGGCATCGGCCTGGCCCGCCGGATGAGCCTGACCGGCGACTACCTGTCGGCG
GCCGACGCGCTGCGGGCCGGGCTGGTCACCGAGGTGGTGCCGCACGACCAGCTGTTGGGCGCCGCCCAGGCCGTGGCGGC
CTCGATCGTCGGGAACAACCAGAACGCGGTGCGCGCGCTGCTGGCCTCCTATCACCGCATCGACGACGCGCAGACCAGCG
CGGGGCTGTGGCAGGAGGCCATGGCGGCCCGGCAGTTCCGGACCAGCGGCGACGACATCGCCGCCAACCGGGAGGCGGTG
CTGGCGCGCGGCCGCTCCCAGGTCCGCTGA

Upstream 100 bases:

>100_bases
ACCGCGCAGTTCGGTGATGTTCCGGCACATGGGTCCAACCATAAGCGCTGCGGCCAGATACCGCCTCCGCTCGCATCGGC
CGGCTGGCTACGGTAAACGC

Downstream 100 bases:

>100_bases
CCGGCACCGACCGGGCGCTCCGTTGGGTCTCATCCCGCCGACCCAATACGATCAGCAGATGCGTGCGGTGGTCGGCGTCA
CCAGGCTGCTCGGCGGGCTC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTDEILLSNTEERVRTLTLNRPQARNALSAALRDRFFGALADAETDDDVDVVIITGADPVFCAGLDLKELGGSSALPDIS
PRWPALTKPVIGAINGAAVTGGLELALYCDILIASENARFADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSA
ADALRAGLVTEVVPHDQLLGAAQAVAASIVGNNQNAVRALLASYHRIDDAQTSAGLWQEAMAARQFRTSGDDIAANREAV
LARGRSQVR

Sequences:

>Translated_249_residues
MTDEILLSNTEERVRTLTLNRPQARNALSAALRDRFFGALADAETDDDVDVVIITGADPVFCAGLDLKELGGSSALPDIS
PRWPALTKPVIGAINGAAVTGGLELALYCDILIASENARFADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSA
ADALRAGLVTEVVPHDQLLGAAQAVAASIVGNNQNAVRALLASYHRIDDAQTSAGLWQEAMAARQFRTSGDDIAANREAV
LARGRSQVR
>Mature_248_residues
TDEILLSNTEERVRTLTLNRPQARNALSAALRDRFFGALADAETDDDVDVVIITGADPVFCAGLDLKELGGSSALPDISP
RWPALTKPVIGAINGAAVTGGLELALYCDILIASENARFADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSAA
DALRAGLVTEVVPHDQLLGAAQAVAASIVGNNQNAVRALLASYHRIDDAQTSAGLWQEAMAARQFRTSGDDIAANREAVL
ARGRSQVR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=191, Percent_Identity=41.8848167539267, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI31542718, Length=224, Percent_Identity=31.6964285714286, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI70995211, Length=250, Percent_Identity=26.4, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI116235487, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI37594469, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594471, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI20127408, Length=174, Percent_Identity=29.3103448275862, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4502327, Length=188, Percent_Identity=32.9787234042553, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI45643119, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI260275230, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI260274832, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI25453481, Length=165, Percent_Identity=27.8787878787879, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538573, Length=165, Percent_Identity=27.8787878787879, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4757966, Length=165, Percent_Identity=27.8787878787879, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538581, Length=165, Percent_Identity=27.8787878787879, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4757968, Length=165, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI49355787, Length=165, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI62530384, Length=170, Percent_Identity=31.1764705882353, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787659, Length=221, Percent_Identity=38.9140271493213, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI221142681, Length=204, Percent_Identity=34.8039215686275, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788597, Length=227, Percent_Identity=32.5991189427313, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=199, Percent_Identity=35.1758793969849, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788682, Length=204, Percent_Identity=31.3725490196078, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790281, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=224, Percent_Identity=37.5, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=186, Percent_Identity=36.5591397849462, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17540714, Length=177, Percent_Identity=37.2881355932203, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=188, Percent_Identity=32.4468085106383, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=185, Percent_Identity=31.8918918918919, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=244, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=193, Percent_Identity=27.4611398963731, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129971, Length=196, Percent_Identity=36.734693877551, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653477, Length=196, Percent_Identity=36.734693877551, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653139, Length=208, Percent_Identity=31.7307692307692, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357171, Length=239, Percent_Identity=27.6150627615063, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650670, Length=194, Percent_Identity=33.5051546391753, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922422, Length=238, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26350; Mature: 26219

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEILLSNTEERVRTLTLNRPQARNALSAALRDRFFGALADAETDDDVDVVIITGADPV
CCCCEEECCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCE
FCAGLDLKELGGSSALPDISPRWPALTKPVIGAINGAAVTGGLELALYCDILIASENARF
EEECCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCEEEEEEEEEEEECCCCCE
ADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSAADALRAGLVTEVVPHDQLLG
ECCCCEEECCCCCCCEEECCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
AAQAVAASIVGNNQNAVRALLASYHRIDDAQTSAGLWQEAMAARQFRTSGDDIAANREAV
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHH
LARGRSQVR
HHCCHHCCC
>Mature Secondary Structure 
TDEILLSNTEERVRTLTLNRPQARNALSAALRDRFFGALADAETDDDVDVVIITGADPV
CCCEEECCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCE
FCAGLDLKELGGSSALPDISPRWPALTKPVIGAINGAAVTGGLELALYCDILIASENARF
EEECCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCEEEEEEEEEEEECCCCCE
ADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSAADALRAGLVTEVVPHDQLLG
ECCCCEEECCCCCCCEEECCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
AAQAVAASIVGNNQNAVRALLASYHRIDDAQTSAGLWQEAMAARQFRTSGDDIAANREAV
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHH
LARGRSQVR
HHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]