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The map label for this gene is cocE [H]

Identifier: 41409000

GI number: 41409000

Start: 3231600

End: 3233327

Strand: Direct

Name: cocE [H]

Synonym: MAP2902

Alternate gene names: 41409000

Gene position: 3231600-3233327 (Clockwise)

Preceding gene: 41408999

Following gene: 41409002

Centisome position: 66.91

GC content: 73.21

Gene sequence:

>1728_bases
GTGAGTCTGACTTCACTTCGCCCGGCGCAGCCGGCGCTGCACACGCTGCGACACCTCGGCGGCAGGGCCGCCGGCCGGCT
GCTGGGCCTGCCTCCGGCCACCACCGACTACACCGTGCGGCGGGTCGCGGTGCCGATGCGCGACGGCGTCGAGCTGGTGG
CCGACCACTACGCGCCCGCCACCTCCGCGCCGGCCGGCACCCTGCTGGTGCGCGCCCCCTACGGACGCGGGTTTCCGTTC
GCGCTGGTGTTCGGCGGGTTGTACGCCGCGCGCGGCTATCACGTTGTGCTGCAAAGCGTGCGCGGAACGTTCGGCTCGGG
CGGGGTGTTCGAGCCGATGGCCCACGAGGTCGCCGACGGCGCCGACACCGTGGCATGGCTGCGCGAACAGCCCTGGTTCA
CCGGCCGCTTCGCCACCATCGGAATGTCCTATCTGGGGTTCACCCAGTGGGCGCTGCTGCAGGACCCGCCGCCGGACATG
GCCACCGCCGTCATCATGGTCGGTCCGCACGACTTCAACGAATCAACTTGGGGCACCGGGTCGTTCGCCGTGAACGACTT
CCTCGGCTGGAGCGACATGGTGTCGCACCAGGAGGACCCGGTGCGCGCCCGGGCCGCGCTGCACCAGCTGCGGGCCCGCC
GCAAGGTGGCCGAAGCGGCGGCCGGGGTGCCGCTCGGCGAGGCCGCCCGGGCGCTGCTGGGCACCGGCGCGCCCTGGTTC
GAATCCTGGATCGAACACGCCGACCCGTCCGATCCGTTCTGGAACTCGTTGCGGTGCAATGAAGCCCTGGACCGGGTGCG
GGTGCCGGTGCTGTTGGTGGGCGGCTGGCAGGACCTCTTCATCCGCCAAACCCTGCAGCAGTACGCGCACTTGCGCGCCC
GCGGCGTCGACGTCGCGCTCACCGTCGGCCCGTGGACCCACACCCAGCTGCTCACCAGCGGGCTGGGCGTCTGCACCCGG
GAGTCGCTGCAGTGGCTGGACACCCACCTGGGTGACGCGCCCGGCCGGCGGGCGGGCCGGGTGCACGTCTACGTCACCGG
CGTGGACCGGTCCCGGGCCTGGCGCCGCCTACCGGACTGGCCCCCGGCCACCACCGAGCGCGCGCTGTACCTGCGCCCCG
GCGGCTACCTGGGCGAGACGGCGCCGAGCCTGAAAGGGTTGGCGCCGGCCACCTTTCGTTACGACCCGGCCCACCCGACG
CCGACCACCGGCGGTCCGTTGCTGTCCCCCAACGGCGGTTACCGCGACGACACCCGGCTGGCGTCCCGCGACGACGTGCT
GGCGTTCACCAGCGCCACCCTCACCGAGGACGTGTACGTGTACGGCAACCCGGTCGTCGAGCTCGCCCACGGCGCCGACC
ATCCGCACGCGGATCTGTTCGTGCGGGTGAGCGAGGTCGACGCAGCGGGCCGGTCGCGCAACGTCACCGAGACCTACCGG
CGGCTCAGCGCCGCGGCAAAACCTCAGGCCGACAAGGTCATTCGCCTCGAACTGGACGGCACGGCCCACCGCTTCCGGGC
CGGCTCGCGCATCCGGCTGCTGATCGCCGGCAGCTGGTCGCCGCGCTACGCCCATAATCTGGGCTCGGGCGAACCGGTGC
TGACCGCCCGGCGGCTCACCCCGGTCACCCACAGCGTGCGTTACGGGCGCTCCCGGCTGCTGCTGCCCGTCGGGCCGGCC
GAGCCGTCAGCCGACGGCGTCGCGGACCCGGTCGGCGACGGCGGCTAG

Upstream 100 bases:

>100_bases
GTTGTACTACTCGACCGTTTACTCCAATCCCGAGGTCGACTGCATGCAAACCAATCTGCAGCGCGCCAACGACCTGGCCC
CCTACTACAAGTTCTAGGCC

Downstream 100 bases:

>100_bases
CGTTTCGTCATCGTGAATCGGCGGCCCCAGCCGAGCGTGCACCGGCAGCTGCACCCAGCTCTTGCAGCCGGCGTAGTCCG
GCGTGCGGGCCAGCCGCACC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSLTSLRPAQPALHTLRHLGGRAAGRLLGLPPATTDYTVRRVAVPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFPF
ALVFGGLYAARGYHVVLQSVRGTFGSGGVFEPMAHEVADGADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDM
ATAVIMVGPHDFNESTWGTGSFAVNDFLGWSDMVSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWF
ESWIEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRARGVDVALTVGPWTHTQLLTSGLGVCTR
ESLQWLDTHLGDAPGRRAGRVHVYVTGVDRSRAWRRLPDWPPATTERALYLRPGGYLGETAPSLKGLAPATFRYDPAHPT
PTTGGPLLSPNGGYRDDTRLASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
RLSAAAKPQADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARRLTPVTHSVRYGRSRLLLPVGPA
EPSADGVADPVGDGG

Sequences:

>Translated_575_residues
MSLTSLRPAQPALHTLRHLGGRAAGRLLGLPPATTDYTVRRVAVPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFPF
ALVFGGLYAARGYHVVLQSVRGTFGSGGVFEPMAHEVADGADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDM
ATAVIMVGPHDFNESTWGTGSFAVNDFLGWSDMVSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWF
ESWIEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRARGVDVALTVGPWTHTQLLTSGLGVCTR
ESLQWLDTHLGDAPGRRAGRVHVYVTGVDRSRAWRRLPDWPPATTERALYLRPGGYLGETAPSLKGLAPATFRYDPAHPT
PTTGGPLLSPNGGYRDDTRLASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
RLSAAAKPQADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARRLTPVTHSVRYGRSRLLLPVGPA
EPSADGVADPVGDGG
>Mature_574_residues
SLTSLRPAQPALHTLRHLGGRAAGRLLGLPPATTDYTVRRVAVPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFPFA
LVFGGLYAARGYHVVLQSVRGTFGSGGVFEPMAHEVADGADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDMA
TAVIMVGPHDFNESTWGTGSFAVNDFLGWSDMVSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWFE
SWIEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRARGVDVALTVGPWTHTQLLTSGLGVCTRE
SLQWLDTHLGDAPGRRAGRVHVYVTGVDRSRAWRRLPDWPPATTERALYLRPGGYLGETAPSLKGLAPATFRYDPAHPTP
TTGGPLLSPNGGYRDDTRLASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYRR
LSAAAKPQADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARRLTPVTHSVRYGRSRLLLPVGPAE
PSADGVADPVGDGG

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 62289; Mature: 62158

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTSLRPAQPALHTLRHLGGRAAGRLLGLPPATTDYTVRRVAVPMRDGVELVADHYAPA
CCCCCCCCCCHHHHHHHHHCCHHHCCEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCC
TSAPAGTLLVRAPYGRGFPFALVFGGLYAARGYHVVLQSVRGTFGSGGVFEPMAHEVADG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHCCC
ADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDMATAVIMVGPHDFNESTWGTG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
SFAVNDFLGWSDMVSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWF
CEEHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
ESWIEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRARGVDVAL
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEE
TVGPWTHTQLLTSGLGVCTRESLQWLDTHLGDAPGRRAGRVHVYVTGVDRSRAWRRLPDW
EECCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHCCCCC
PPATTERALYLRPGGYLGETAPSLKGLAPATFRYDPAHPTPTTGGPLLSPNGGYRDDTRL
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCC
ASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
CCCCCEEEEECCHHCCCEEEECCCEEEECCCCCCCCCEEEEEEEHHCCCCCCCCHHHHHH
RLSAAAKPQADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARRLT
HHHHHCCCCCCCEEEEEECCCHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEHHCC
PVTHSVRYGRSRLLLPVGPAEPSADGVADPVGDGG
CHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLTSLRPAQPALHTLRHLGGRAAGRLLGLPPATTDYTVRRVAVPMRDGVELVADHYAPA
CCCCCCCCCHHHHHHHHHCCHHHCCEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCC
TSAPAGTLLVRAPYGRGFPFALVFGGLYAARGYHVVLQSVRGTFGSGGVFEPMAHEVADG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHCCC
ADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDMATAVIMVGPHDFNESTWGTG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
SFAVNDFLGWSDMVSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWF
CEEHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
ESWIEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRARGVDVAL
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEE
TVGPWTHTQLLTSGLGVCTRESLQWLDTHLGDAPGRRAGRVHVYVTGVDRSRAWRRLPDW
EECCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHCCCCC
PPATTERALYLRPGGYLGETAPSLKGLAPATFRYDPAHPTPTTGGPLLSPNGGYRDDTRL
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCC
ASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
CCCCCEEEEECCHHCCCEEEECCCEEEECCCCCCCCCEEEEEEEHHCCCCCCCCHHHHHH
RLSAAAKPQADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARRLT
HHHHHCCCCCCCEEEEEECCCHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEHHCC
PVTHSVRYGRSRLLLPVGPAEPSADGVADPVGDGG
CHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]