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The map label for this gene is dapA

Identifier: 41408962

GI number: 41408962

Start: 3191844

End: 3192746

Strand: Reverse

Name: dapA

Synonym: MAP2864c

Alternate gene names: 41408962

Gene position: 3192746-3191844 (Counterclockwise)

Preceding gene: 41408963

Following gene: 41408961

Centisome position: 66.11

GC content: 70.76

Gene sequence:

>903_bases
GTGAGCACGGTCGGATTCGACGCCCCAGCGCGGTTGGGAACCGTGCTGACCGCGATGGTCACGCCGTTCGCGGCCGACGG
CTCGCTGGACACCGCCGCCGCCGCGCGGCTGGCCAATCATCTCGTCGACTCCGGCTGTGACGGGCTGGTGGTGTCCGGAA
CCACCGGCGAATCGCCGACCACCACCGACGACGAGAAGCGCGAGCTGCTGCGGGTGGTGCTGGAAGCGGTCGGCGACCGG
GCCCGCGTCATCGCCGGCGCCGGCACCTACGACACCGCGCACAGCGTCCGGCTGGCCAAGGCCTGCGCGGCTGAGGGCGC
GCACGGTCTGCTGGTGGTCACGCCCTACTACTCGAAGCCCCCGCAGCGCGGGCTGATCGCGCATTTCACCGCCGTCGCCG
ACGCGACCGAACTGCCGGTGCTGCTCTACGACATTCCCGGACGCTCGGTGGTGCCCATCGAGTCGAGCACCATCCGCGCG
CTGGCGTCGCACCCCAACATCGTCGGCGTCAAGGACGCCAAGGCCGACCTGCACGCCGGCGGCCAGATCATCGCCGAGAC
CGGACTGGCCTACTACTCCGGAGACGACGCGCTGAACCTGCCGTGGCTGGCCATGGGGGCCACCGGTTTCATCAGCGTGA
TCTCGCACGTCGCCGCCAATCAGCTACGGGAGTTGTTGTCCGCCTTCACTTCCGGGGACATCGCCACCGCCCGCAAGATC
AACGCGACCGTCACGCCGCTGTGCGACGCGATGGCCCGCCTGGGCGGGGTGACGATGTCGAAGGCGGGGCTGCGGCTGCA
GGGCATCGACGTCGGCGACCCGCGACTGCCGCAGGTGCCGGCGACGCCCGAGCAGATCGAGGCGTTGACCGCCGACATGC
GTGCGGCCTCGGTGCTCAGGTGA

Upstream 100 bases:

>100_bases
GCCACGCTGGCCGACGGCACCGAGGTCGCCACCAGCCCGCTGGCCACCGAGGCCTGAGCGGTCACGAAACCCCTTGCCCC
CGCCAGGTAACCTGAACAGC

Downstream 100 bases:

>100_bases
CCCGGGGAGCGTCCGAGCAGTGGATGTAGACCTCGCCCCGCCTGGCCCGCTGGCCGCCGGGGGGTTGCGGGTCACCGCGC
TGGGCGGCATCAGCGAAATC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSTVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDR
ARVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVADATELPVLLYDIPGRSVVPIESSTIRA
LASHPNIVGVKDAKADLHAGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKI
NATVTPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASVLR

Sequences:

>Translated_300_residues
MSTVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDR
ARVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVADATELPVLLYDIPGRSVVPIESSTIRA
LASHPNIVGVKDAKADLHAGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKI
NATVTPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASVLR
>Mature_299_residues
STVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRA
RVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVADATELPVLLYDIPGRSVVPIESSTIRAL
ASHPNIVGVKDAKADLHAGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKIN
ATVTPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASVLR

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=28.5211267605634, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13540533, Length=300, Percent_Identity=27.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788823, Length=287, Percent_Identity=34.1463414634146, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=30.0411522633745, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786463, Length=277, Percent_Identity=30.3249097472924, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082415, Length=284, Percent_Identity=27.8169014084507, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_MYCPA (Q73VZ7)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961798.1
- HSSP:   P63945
- ProteinModelPortal:   Q73VZ7
- SMR:   Q73VZ7
- EnsemblBacteria:   EBMYCT00000038351
- GeneID:   2721019
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2864c
- NMPDR:   fig|262316.1.peg.2864
- GeneTree:   EBGT00050000016215
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30974; Mature: 30842

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 171-171 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPT
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
TTDDEKRELLRVVLEAVGDRARVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKP
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PQRGLIAHFTAVADATELPVLLYDIPGRSVVPIESSTIRALASHPNIVGVKDAKADLHAG
CCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCHHHHHHHHCCCCEEEECCCCHHHHCC
GQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKI
CEEEECCCCEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
NATVTPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASVLR
CCCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPT
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
TTDDEKRELLRVVLEAVGDRARVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKP
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PQRGLIAHFTAVADATELPVLLYDIPGRSVVPIESSTIRALASHPNIVGVKDAKADLHAG
CCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCHHHHHHHHCCCCEEEECCCCHHHHCC
GQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKI
CEEEECCCCEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
NATVTPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASVLR
CCCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA