| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is dxs
Identifier: 41408901
GI number: 41408901
Start: 3133184
End: 3135109
Strand: Reverse
Name: dxs
Synonym: MAP2803c
Alternate gene names: 41408901
Gene position: 3135109-3133184 (Counterclockwise)
Preceding gene: 41408904
Following gene: 41408897
Centisome position: 64.91
GC content: 71.5
Gene sequence:
>1926_bases ATGCTGGAACAGATCCGCGGGCCCGCTGATCTGCAGCACCTTTCGACGCATCAGCTCCGCGAACTGGCCGCCGAGATTCG CGAGTTCCTGATCCACAAGGTCGCTGCCACCGGGGGGCATCTGGGGCCCAACCTCGGCGTGGTCGAGCTGACGCTCGCGC TGCACCGGGTGTTCGACTCGCCGCACGACCCGATCATCTTCGACACCGGCCATCAGGCCTACGTGCACAAGATGCTGACG GGGCGGGCGCACGAGTTCGAAAGCCTGCGCAAAAAGGGTGGCCTGTCGGGGTATCCGTCGCGCAGCGAAAGCGAACACGA CTGGGTGGAGTCCAGCCACGCCAGCGCCGCCCTGTCCTACGCCGACGGCCTGGCCAAGGCCTTCGAGCTGAGCGGGCACC GCAACCGGCACGTGGTCGCGGTGGTCGGCGACGGCGCGCTCACCGGCGGCATGTGCTGGGAGGCGCTGAACAACATCGCC GCGTCCGGCCGCCCGGTGATCATCGTGGTCAACGACAACGGCCGCAGCTACGCGCCGACGATCGGCGGGGTGGCCGACCA CCTGGCCACGCTGCGGCTGCAACCCGCCTACGAGCAGGCGCTTCAGCGGGGTCGCGACGCGCTGCGGGCGCTGCCGCTGG TGGGCAAGTTCGCCTACCGGGTGATGCACAGCGTCAAGGCCGGCATCAAGGACTCGCTGTCGCCGCAGCTGCTGTTCACC GACCTCGGGCTGAAGTACGTCGGCCCCGTCGACGGCCACGACGAACGCGCGGTGGAGGCCGCGCTGCGCCATGCCCGCGG CTTCGGGCGCCCGGTGATCGTGCACGTGGTGACCCGCAAGGGGATGGGCTACGCGCCCGCCGAGGACGACGAGGCCGACC AGATGCATTCCTGCGGCGTGATCGACCCGGTCACCGGGCAGGCCACCAAGGTCGCCGGGCCCGGCTGGACGGCGACCTTC TCCGACGCGCTGATCGGCTACGCCCGCAAGCGCCGCGACATCGTGGCCATCACCGCGGCCATGCCCGGGCCCACCGGGCT GACGCCGTTCGGCCAGCAGTTCCCCGACCGCCTGTTCGACGTCGGCATCGCCGAACAGCACGCGATGACCTCGGCGGCCG GCCTGGCCATGGGCGGCATGCACCCGGTGGTGGCCATCTACTCGACGTTCCTCAACCGCGCCTTCGACCAGATCATGATG GACGTCGCGCTGCACCGGCTGCCGGTCACCATGGTGCTGGACCGGGCCGGCATCACCGGTTCGGACGGCGCCAGCCACAA CGGCATGTGGGACCTGTCCATCCTCGGCGTCGTGCCCGGCATGCGGGTGGCCGCACCCCGCGACGCCGCCCGGTTGCGCG AGGAGCTCGGCGAGGCGCTCGACGTCGACGACGGGCCCACGGCGCTGCGCTTCCCCAAAGGTGATGTGGGCGAGGACATT CCGGCGATCGAGCGGCGCGGCTCCGGCCTGTCGGGCGTCGACGTGCTGGCCCTGCCGGCCAGCGGCTGCAACCACGACGT GCTGCTGATCGGCGTCGGCGCGTTCGCGCCGATGGCCCTGGCGGTGGCCAGGCGGCTGGCGGATCAGGGCATCGGCGTCA CGGTCGTCGATCCGCGCTGGGTGCTGCCGGTCTCGGATTCCATCCTGGAGCTGGCGGCCCGGCACAAGCTGGTGGTCACC TGTGAGGACAACGGCGTCAACGGCGGGGTGGGGTCGGCGGTCTCGGCCGCGCTGCGCCGCGCCGAGCTCGACGTCCCGTG CCGCGACGTCGGATTGCCGCAGCGGTTCTACGAGCACGCCTCGCGCGGGGAGCTGCTGGCGGATCTGGCGCTGACCGATC AGGACATCGCCCGCCGCATCACCGGCTGGGTCGCCGCGCTGGGCAGCGGCGTGGCCGAGGCCGAGATCCGCGAGCACCTC GACTAG
Upstream 100 bases:
>100_bases GTCCTCGGCCAGTTCCGCCGCGCGCATACCCAGGACAATACGACGAGCGCCGGCCACATTGATCAGTAGTGTTCCGCCGG GCGCTGCGTAGACTGACGGG
Downstream 100 bases:
>100_bases TCACGGGTCTCAGCGCCCGCCCGGCCCGGCGCGGCCGGTGCGCGTCAGCCGTCGTCGTCCGCAACCGCCGGCAGCGGCTG CTGCAGCGCCCGGGCCAGGA
Product: 1-deoxy-D-xylulose-5-phosphate synthase
Products: NA
Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]
Number of amino acids: Translated: 641; Mature: 641
Protein sequence:
>641_residues MLEQIRGPADLQHLSTHQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT GRAHEFESLRKKGGLSGYPSRSESEHDWVESSHASAALSYADGLAKAFELSGHRNRHVVAVVGDGALTGGMCWEALNNIA ASGRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALQRGRDALRALPLVGKFAYRVMHSVKAGIKDSLSPQLLFT DLGLKYVGPVDGHDERAVEAALRHARGFGRPVIVHVVTRKGMGYAPAEDDEADQMHSCGVIDPVTGQATKVAGPGWTATF SDALIGYARKRRDIVAITAAMPGPTGLTPFGQQFPDRLFDVGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMM DVALHRLPVTMVLDRAGITGSDGASHNGMWDLSILGVVPGMRVAAPRDAARLREELGEALDVDDGPTALRFPKGDVGEDI PAIERRGSGLSGVDVLALPASGCNHDVLLIGVGAFAPMALAVARRLADQGIGVTVVDPRWVLPVSDSILELAARHKLVVT CEDNGVNGGVGSAVSAALRRAELDVPCRDVGLPQRFYEHASRGELLADLALTDQDIARRITGWVAALGSGVAEAEIREHL D
Sequences:
>Translated_641_residues MLEQIRGPADLQHLSTHQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT GRAHEFESLRKKGGLSGYPSRSESEHDWVESSHASAALSYADGLAKAFELSGHRNRHVVAVVGDGALTGGMCWEALNNIA ASGRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALQRGRDALRALPLVGKFAYRVMHSVKAGIKDSLSPQLLFT DLGLKYVGPVDGHDERAVEAALRHARGFGRPVIVHVVTRKGMGYAPAEDDEADQMHSCGVIDPVTGQATKVAGPGWTATF SDALIGYARKRRDIVAITAAMPGPTGLTPFGQQFPDRLFDVGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMM DVALHRLPVTMVLDRAGITGSDGASHNGMWDLSILGVVPGMRVAAPRDAARLREELGEALDVDDGPTALRFPKGDVGEDI PAIERRGSGLSGVDVLALPASGCNHDVLLIGVGAFAPMALAVARRLADQGIGVTVVDPRWVLPVSDSILELAARHKLVVT CEDNGVNGGVGSAVSAALRRAELDVPCRDVGLPQRFYEHASRGELLADLALTDQDIARRITGWVAALGSGVAEAEIREHL D >Mature_641_residues MLEQIRGPADLQHLSTHQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT GRAHEFESLRKKGGLSGYPSRSESEHDWVESSHASAALSYADGLAKAFELSGHRNRHVVAVVGDGALTGGMCWEALNNIA ASGRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALQRGRDALRALPLVGKFAYRVMHSVKAGIKDSLSPQLLFT DLGLKYVGPVDGHDERAVEAALRHARGFGRPVIVHVVTRKGMGYAPAEDDEADQMHSCGVIDPVTGQATKVAGPGWTATF SDALIGYARKRRDIVAITAAMPGPTGLTPFGQQFPDRLFDVGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMM DVALHRLPVTMVLDRAGITGSDGASHNGMWDLSILGVVPGMRVAAPRDAARLREELGEALDVDDGPTALRFPKGDVGEDI PAIERRGSGLSGVDVLALPASGCNHDVLLIGVGAFAPMALAVARRLADQGIGVTVVDPRWVLPVSDSILELAARHKLVVT CEDNGVNGGVGSAVSAALRRAELDVPCRDVGLPQRFYEHASRGELLADLALTDQDIARRITGWVAALGSGVAEAEIREHL D
Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]
COG id: COG1154
COG function: function code HI; Deoxyxylulose-5-phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transketolase family. DXPS subfamily [H]
Homologues:
Organism=Homo sapiens, GI205277463, Length=260, Percent_Identity=27.3076923076923, Blast_Score=83, Evalue=8e-16, Organism=Homo sapiens, GI4507521, Length=260, Percent_Identity=27.3076923076923, Blast_Score=83, Evalue=8e-16, Organism=Homo sapiens, GI133778974, Length=310, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=4e-13, Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=39.2914653784219, Blast_Score=434, Evalue=1e-123, Organism=Drosophila melanogaster, GI24666278, Length=621, Percent_Identity=25.2818035426731, Blast_Score=83, Evalue=5e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005477 - InterPro: IPR011766 - InterPro: IPR009014 - InterPro: IPR015941 - InterPro: IPR005475 - InterPro: IPR020826 - InterPro: IPR005476 - InterPro: IPR005474 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]
EC number: =2.2.1.7 [H]
Molecular weight: Translated: 68263; Mature: 68263
Theoretical pI: Translated: 6.42; Mature: 6.42
Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLEQIRGPADLQHLSTHQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC PHDPIIFDTGHQAYVHKMLTGRAHEFESLRKKGGLSGYPSRSESEHDWVESSHASAALSY CCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH ADGLAKAFELSGHRNRHVVAVVGDGALTGGMCWEALNNIAASGRPVIIVVNDNGRSYAPT HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCC IGGVADHLATLRLQPAYEQALQRGRDALRALPLVGKFAYRVMHSVKAGIKDSLSPQLLFT CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE DLGLKYVGPVDGHDERAVEAALRHARGFGRPVIVHVVTRKGMGYAPAEDDEADQMHSCGV ECCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCCC IDPVTGQATKVAGPGWTATFSDALIGYARKRRDIVAITAAMPGPTGLTPFGQQFPDRLFD CCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHH VGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMMDVALHRLPVTMVLDRAGITG CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCC SDGASHNGMWDLSILGVVPGMRVAAPRDAARLREELGEALDVDDGPTALRFPKGDVGEDI CCCCCCCCEEEEEHHHCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCC PAIERRGSGLSGVDVLALPASGCNHDVLLIGVGAFAPMALAVARRLADQGIGVTVVDPRW CHHHHCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCEE VLPVSDSILELAARHKLVVTCEDNGVNGGVGSAVSAALRRAELDVPCRDVGLPQRFYEHA EECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHC SRGELLADLALTDQDIARRITGWVAALGSGVAEAEIREHLD CCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC >Mature Secondary Structure MLEQIRGPADLQHLSTHQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC PHDPIIFDTGHQAYVHKMLTGRAHEFESLRKKGGLSGYPSRSESEHDWVESSHASAALSY CCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH ADGLAKAFELSGHRNRHVVAVVGDGALTGGMCWEALNNIAASGRPVIIVVNDNGRSYAPT HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCC IGGVADHLATLRLQPAYEQALQRGRDALRALPLVGKFAYRVMHSVKAGIKDSLSPQLLFT CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE DLGLKYVGPVDGHDERAVEAALRHARGFGRPVIVHVVTRKGMGYAPAEDDEADQMHSCGV ECCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCCC IDPVTGQATKVAGPGWTATFSDALIGYARKRRDIVAITAAMPGPTGLTPFGQQFPDRLFD CCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHH VGIAEQHAMTSAAGLAMGGMHPVVAIYSTFLNRAFDQIMMDVALHRLPVTMVLDRAGITG CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCC SDGASHNGMWDLSILGVVPGMRVAAPRDAARLREELGEALDVDDGPTALRFPKGDVGEDI CCCCCCCCEEEEEHHHCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCC PAIERRGSGLSGVDVLALPASGCNHDVLLIGVGAFAPMALAVARRLADQGIGVTVVDPRW CHHHHCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCEE VLPVSDSILELAARHKLVVTCEDNGVNGGVGSAVSAALRRAELDVPCRDVGLPQRFYEHA EECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHC SRGELLADLALTDQDIARRITGWVAALGSGVAEAEIREHLD CCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA