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The map label for this gene is tesB2

Identifier: 41408807

GI number: 41408807

Start: 3044926

End: 3045762

Strand: Reverse

Name: tesB2

Synonym: MAP2709c

Alternate gene names: 41408807

Gene position: 3045762-3044926 (Counterclockwise)

Preceding gene: 41408808

Following gene: 41408806

Centisome position: 63.06

GC content: 68.22

Gene sequence:

>837_bases
GTGTCGATCGAGCAGATCCTTGATCTCGAGCAACTCGAGGTCAACATCTACCGCGGGGGCGTCTTCAGCCCGGATTCCGG
ATATTTCCAGCGCACCTTCGGCGGCCATGTGGCCGGCCAGTCGCTGGTGTCGGCGGTGCGCACGGTCGACCCGCGCTACC
AGGTGCACTCGCTGCACGGGTACTTCCTGCGGCCTGGGGACGCCAAGGAGCGCACGGTGTTCATCGTGGAGCGCACCCGC
GACGGCGGCTCGTTTGCCACCCGGCGGGTCAACGCGATTCAGCACGGCGAGATCATCTTCTCCATGGGCGCGTCGTTCCA
GACCGACCAGGAGGGCATCCACCACCAGGACGCCATGCCGGCCGCGCCGCCCCCGGACGGCCTGCCCGGCCTGGACTCGA
TCAAGGTGTTCGACGACGCCGGGTTCAAGCAGTTCGAGGAGTGGGACGTCTGCATCGTGCCGCGGGAGAAGCTGCAGCTG
ACCCCGGGCAAGGCGTCCCAGCAGCAGGTGTGGTTCCGCCACCGCGACCCGTTGCCCGACGACCCGGTGCTGCACATCTG
CGCGCTGGCCTACATGAGCGACCTGACGCTGCTGGGCTCGGCGCAGGTCACCCACCTCGATGTGCGCGAGCACCTGCAGG
TGGCGTCGCTGGACCACGCCATGTGGTTCATGCGGGCGTTCCGCGCCGACGAGTGGCTGCTCTACGACCAGTCCTCGCCG
TCGGCCAACGGCGGCCGCTCGCTGTGCCAGGGCAAGATCTTCACCCAGTCCGGCGAGATGGTGGCCGCGGTCATGCAGGA
GGGGCTGACCCGCTTCCAGCGGGGATATCGGCAGTGA

Upstream 100 bases:

>100_bases
CAAGGTGTCACGCGGGCTGGGCGAGGCGATGGTCGGCATCAACGTCGAGCAGATCGCGCAGCCCGAACGGCTGGCGGAAC
GCGGCTGGTAAGAACAATCC

Downstream 100 bases:

>100_bases
GCGCCCCGCGGATCGGGGTGCTGGCGCTGCAGGGCGACACCCGCGAGCATCTGGCCGCGCTGCGCGAGGCCGGGGCCGAG
TCGATGCCGGTGCGCCGCCG

Product: TesB2

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSIEQILDLEQLEVNIYRGGVFSPDSGYFQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHGYFLRPGDAKERTVFIVERTR
DGGSFATRRVNAIQHGEIIFSMGASFQTDQEGIHHQDAMPAAPPPDGLPGLDSIKVFDDAGFKQFEEWDVCIVPREKLQL
TPGKASQQQVWFRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLDVREHLQVASLDHAMWFMRAFRADEWLLYDQSSP
SANGGRSLCQGKIFTQSGEMVAAVMQEGLTRFQRGYRQ

Sequences:

>Translated_278_residues
MSIEQILDLEQLEVNIYRGGVFSPDSGYFQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHGYFLRPGDAKERTVFIVERTR
DGGSFATRRVNAIQHGEIIFSMGASFQTDQEGIHHQDAMPAAPPPDGLPGLDSIKVFDDAGFKQFEEWDVCIVPREKLQL
TPGKASQQQVWFRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLDVREHLQVASLDHAMWFMRAFRADEWLLYDQSSP
SANGGRSLCQGKIFTQSGEMVAAVMQEGLTRFQRGYRQ
>Mature_277_residues
SIEQILDLEQLEVNIYRGGVFSPDSGYFQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHGYFLRPGDAKERTVFIVERTRD
GGSFATRRVNAIQHGEIIFSMGASFQTDQEGIHHQDAMPAAPPPDGLPGLDSIKVFDDAGFKQFEEWDVCIVPREKLQLT
PGKASQQQVWFRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLDVREHLQVASLDHAMWFMRAFRADEWLLYDQSSPS
ANGGRSLCQGKIFTQSGEMVAAVMQEGLTRFQRGYRQ

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=287, Percent_Identity=36.5853658536585, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1786657, Length=275, Percent_Identity=41.0909090909091, Blast_Score=188, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71988741, Length=297, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17558508, Length=312, Percent_Identity=32.3717948717949, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531889, Length=267, Percent_Identity=30.7116104868914, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI115532456, Length=267, Percent_Identity=30.7116104868914, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17531885, Length=267, Percent_Identity=30.7116104868914, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=303, Percent_Identity=28.3828382838284, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI212645202, Length=260, Percent_Identity=28.8461538461538, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31223; Mature: 31091

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEQILDLEQLEVNIYRGGVFSPDSGYFQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHG
CCHHHHHCHHHEEEEEEECCCCCCCCCCEEHHCCCHHHHHHHHHHHHHCCCCEEEEECCE
YFLRPGDAKERTVFIVERTRDGGSFATRRVNAIQHGEIIFSMGASFQTDQEGIHHQDAMP
EEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCC
AAPPPDGLPGLDSIKVFDDAGFKQFEEWDVCIVPREKLQLTPGKASQQQVWFRHRDPLPD
CCCCCCCCCCCCCEEEECCCCCCHHCCCCEEEECHHHEEECCCCCCHHHHHHHCCCCCCC
DPVLHICALAYMSDLTLLGSAQVTHLDVREHLQVASLDHAMWFMRAFRADEWLLYDQSSP
CHHHHHHHHHHHHHHHEECCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
SANGGRSLCQGKIFTQSGEMVAAVMQEGLTRFQRGYRQ
CCCCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIEQILDLEQLEVNIYRGGVFSPDSGYFQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHG
CHHHHHCHHHEEEEEEECCCCCCCCCCEEHHCCCHHHHHHHHHHHHHCCCCEEEEECCE
YFLRPGDAKERTVFIVERTRDGGSFATRRVNAIQHGEIIFSMGASFQTDQEGIHHQDAMP
EEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCC
AAPPPDGLPGLDSIKVFDDAGFKQFEEWDVCIVPREKLQLTPGKASQQQVWFRHRDPLPD
CCCCCCCCCCCCCEEEECCCCCCHHCCCCEEEECHHHEEECCCCCCHHHHHHHCCCCCCC
DPVLHICALAYMSDLTLLGSAQVTHLDVREHLQVASLDHAMWFMRAFRADEWLLYDQSSP
CHHHHHHHHHHHHHHHEECCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
SANGGRSLCQGKIFTQSGEMVAAVMQEGLTRFQRGYRQ
CCCCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]