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The map label for this gene is gnd2

Identifier: 41408768

GI number: 41408768

Start: 3007105

End: 3008127

Strand: Reverse

Name: gnd2

Synonym: MAP2670c

Alternate gene names: 41408768

Gene position: 3008127-3007105 (Counterclockwise)

Preceding gene: 41408769

Following gene: 41408766

Centisome position: 62.28

GC content: 67.94

Gene sequence:

>1023_bases
ATGCAGCTGGGGATGATCGGCCTGGGCCGGATGGGTGCCAACATCGTCCGACGGGTGGTCAAGGGCGGACACGAATGCGT
TGTCTACGACCACAATCCGGACGCGGTCAAGGCGATGGCGGGGGAGGAGAAGACGACCGGGGTCTCCTCGCTGCAAGAGC
TCGCCGCGAAGCTGAGCGCCCCGCGGGTGGTGTGGGTGATGGTGCCGGCCGGGACGATCACCACCGGGGTGATCGAGGAG
CTGGCCACCACGCTGGAGCCCGGCGACATCGTCATCGACGGCGGCAACTCCTACTACCGCGACGACATTCGTCACTCGAA
GACCCTGTCGGAGAAGGGGATTCGGCTGCTGGACTGCGGCACCAGCGGCGGCGTCTGGGGCCGGGAACGGGGTTACTGCC
TGATGATCGGCGGCGACGAGGAGGCGTTCGCGCACGCCGAGCCGATCTTCGCCACCGTCGCACCGGGGGTGGACGCCGCG
CCGCGGACGCCGGGCCGCGACGGCGAGGTCACCCGGTCGGAGCAGGGGTATCTGCATTGCGGGCCGTCCGGCGCCGGGCA
CTTCGTGAAGATGGTGCACAACGGCATCGAGTACGGGATGATGGCCTCGCTCGCCGAGGGACTCAACGTGTTGCGCAACG
CCGACATCGGCAAGCACGCGCAGGAAGGCGACGCCGAAACCGCGCCGCTGTCCAATCCCGAGTTCTACCAATACGATTTC
GACATCCCCGAGGTCGCCGAGGTGTGGCGGCGCGGCAGCGTCATCGGATCCTGGCTGCTGGATCTCACGGCGATCGCACT
GCACGAATCACCGGAGCTCAAGGAGTTCTCCGGGCGGGTCTCCGACTCGGGGGAGGGCCGCTGGACGTCCATCGCCGCGA
TCGACGAGGGGGTCCCCACGCCGGTGCTGACCACCGCGCTGCAGTCCCGCTTCGCTTCCCGGCATCTCGATGACTTCGCC
AACAAGACGCTCTCGGCGATGCGTAAGCAATTCGGCGGGCACGCCGAGAAGCCGGCCAACTAG

Upstream 100 bases:

>100_bases
CCCGAGGCCGCGCAGGCGCTGGTGCACGGTCGCCACGCCTGGCAGCAACCGTGGCTGCCGCAGAGCACGTCCACGAAACG
ATAAGGAGGCTCGAGACACG

Downstream 100 bases:

>100_bases
CCGCGCGGATTTCTCAGCGGCGCTTGACGAACGCCACCACGGCGTCGCTGAACGCGTCGTTGTCGTCGCCGGCCGCGGTG
TGCCCGGCGTTGGACAGCTC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQLGMIGLGRMGANIVRRVVKGGHECVVYDHNPDAVKAMAGEEKTTGVSSLQELAAKLSAPRVVWVMVPAGTITTGVIEE
LATTLEPGDIVIDGGNSYYRDDIRHSKTLSEKGIRLLDCGTSGGVWGRERGYCLMIGGDEEAFAHAEPIFATVAPGVDAA
PRTPGRDGEVTRSEQGYLHCGPSGAGHFVKMVHNGIEYGMMASLAEGLNVLRNADIGKHAQEGDAETAPLSNPEFYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALHESPELKEFSGRVSDSGEGRWTSIAAIDEGVPTPVLTTALQSRFASRHLDDFA
NKTLSAMRKQFGGHAEKPAN

Sequences:

>Translated_340_residues
MQLGMIGLGRMGANIVRRVVKGGHECVVYDHNPDAVKAMAGEEKTTGVSSLQELAAKLSAPRVVWVMVPAGTITTGVIEE
LATTLEPGDIVIDGGNSYYRDDIRHSKTLSEKGIRLLDCGTSGGVWGRERGYCLMIGGDEEAFAHAEPIFATVAPGVDAA
PRTPGRDGEVTRSEQGYLHCGPSGAGHFVKMVHNGIEYGMMASLAEGLNVLRNADIGKHAQEGDAETAPLSNPEFYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALHESPELKEFSGRVSDSGEGRWTSIAAIDEGVPTPVLTTALQSRFASRHLDDFA
NKTLSAMRKQFGGHAEKPAN
>Mature_340_residues
MQLGMIGLGRMGANIVRRVVKGGHECVVYDHNPDAVKAMAGEEKTTGVSSLQELAAKLSAPRVVWVMVPAGTITTGVIEE
LATTLEPGDIVIDGGNSYYRDDIRHSKTLSEKGIRLLDCGTSGGVWGRERGYCLMIGGDEEAFAHAEPIFATVAPGVDAA
PRTPGRDGEVTRSEQGYLHCGPSGAGHFVKMVHNGIEYGMMASLAEGLNVLRNADIGKHAQEGDAETAPLSNPEFYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALHESPELKEFSGRVSDSGEGRWTSIAAIDEGVPTPVLTTALQSRFASRHLDDFA
NKTLSAMRKQFGGHAEKPAN

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=346, Percent_Identity=32.6589595375723, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1788341, Length=337, Percent_Identity=30.2670623145401, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17542558, Length=325, Percent_Identity=32.6153846153846, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=325, Percent_Identity=32, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6321977, Length=320, Percent_Identity=31.875, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24639279, Length=320, Percent_Identity=30.9375, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24655230, Length=213, Percent_Identity=26.7605633802817, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922568, Length=213, Percent_Identity=26.7605633802817, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 36460; Mature: 36460

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMIGLGRMGANIVRRVVKGGHECVVYDHNPDAVKAMAGEEKTTGVSSLQELAAKLSA
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCC
PRVVWVMVPAGTITTGVIEELATTLEPGDIVIDGGNSYYRDDIRHSKTLSEKGIRLLDCG
CEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECC
TSGGVWGRERGYCLMIGGDEEAFAHAEPIFATVAPGVDAAPRTPGRDGEVTRSEQGYLHC
CCCCCCCCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
GPSGAGHFVKMVHNGIEYGMMASLAEGLNVLRNADIGKHAQEGDAETAPLSNPEFYQYDF
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEC
DIPEVAEVWRRGSVIGSWLLDLTAIALHESPELKEFSGRVSDSGEGRWTSIAAIDEGVPT
CCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCC
PVLTTALQSRFASRHLDDFANKTLSAMRKQFGGHAEKPAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLGMIGLGRMGANIVRRVVKGGHECVVYDHNPDAVKAMAGEEKTTGVSSLQELAAKLSA
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCC
PRVVWVMVPAGTITTGVIEELATTLEPGDIVIDGGNSYYRDDIRHSKTLSEKGIRLLDCG
CEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECC
TSGGVWGRERGYCLMIGGDEEAFAHAEPIFATVAPGVDAAPRTPGRDGEVTRSEQGYLHC
CCCCCCCCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
GPSGAGHFVKMVHNGIEYGMMASLAEGLNVLRNADIGKHAQEGDAETAPLSNPEFYQYDF
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEC
DIPEVAEVWRRGSVIGSWLLDLTAIALHESPELKEFSGRVSDSGEGRWTSIAAIDEGVPT
CCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCC
PVLTTALQSRFASRHLDDFANKTLSAMRKQFGGHAEKPAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]