Click here to switch to the map view.

The map label for this gene is cobB

Identifier: 41408731

GI number: 41408731

Start: 2966497

End: 2967210

Strand: Direct

Name: cobB

Synonym: MAP2633

Alternate gene names: 41408731

Gene position: 2966497-2967210 (Clockwise)

Preceding gene: 41408729

Following gene: 41408734

Centisome position: 61.42

GC content: 71.15

Gene sequence:

>714_bases
ATGCGCATAGCGGTGCTCAGCGGCGCGGGCATCTCCGCGGAGAGCGGGGTGCCGACCTTCCGCGACGACAAGAACGGACT
GTGGGCCCGCTTCGACCCCTACGAGCTGTCCAGCACCCAGGGGTGGCGCGACAACCCGCAGCGCGTCTGGGGCTGGTATC
TGTGGCGTCACTACCTGGTGGCCGACGTCGCGCCGAACGCGGGTCATCGCGCGATCGCCGCCTGGCAAGACCACGCCGAG
GTCAGCGTCATCACGCAGAACGTCGACGACCTGCACGAGCGGGCCGGTAGCCGGCCCGTGCACCACCTGCACGGCAGCCT
GTTCGAATTCCGTTGCGCCCGTTGCGCAAAGCCCTACACCGGCGAGCTGCCGGCGATGGCCGAACCGGCGCTGGAGGTGC
AACCCCCGGTGTGCGGATGCGGCGGCCTGATCAGGCCCGACATCGTGTGGTTCGGCGAACAGCTGCCCGACGAGCCGTGG
CGGCGTGCCGTCGAGGCGACCGAGTCCGCCGACGTGATGGTGGTGGTGGGCACCTCGGCGATCGTGTATCCGGCGGCCGG
GCTGGCCGAGCTGGCGTTGTCCCGCGGCGCCGCCGTCGTCGAGGTCAATCCCGAGGTCACGCCGCTGTCGGCCAGCGCCA
CGCTCAGCATCCGGGAGACGGCCAGCCAGGCCTTGCCCGGGCTGCTGCAGCGGTTGCCGGCGCTGCTCAACTGA

Upstream 100 bases:

>100_bases
GAGCTGGTCGAAAAGCGGCTTGCCCGCCTTCATGTCGACCCGCAACCAGTCACCCAGCTCCACTCGTTCAGTATCGCTCA
GCCGCGGCTATCTTGGTGGG

Downstream 100 bases:

>100_bases
GCGCGGACTAGGCGGGCCGGTGCGCGCGGCCCAGCAACAGCTCCGACACCGGCATCGGCGACCAGGCCGGCAACGTCCAC
TCCCGCCGCGACGCGTCGAC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVAPNAGHRAIAAWQDHAE
VSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYTGELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPW
RRAVEATESADVMVVVGTSAIVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN

Sequences:

>Translated_237_residues
MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVAPNAGHRAIAAWQDHAE
VSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYTGELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPW
RRAVEATESADVMVVVGTSAIVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN
>Mature_237_residues
MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLVADVAPNAGHRAIAAWQDHAE
VSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYTGELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPW
RRAVEATESADVMVVVGTSAIVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=39.8305084745763, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6912664, Length=250, Percent_Identity=38, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI13787215, Length=229, Percent_Identity=40.174672489083, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI6912662, Length=256, Percent_Identity=28.515625, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI6912660, Length=199, Percent_Identity=31.6582914572864, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI63054862, Length=195, Percent_Identity=31.2820512820513, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI13775602, Length=235, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI13775600, Length=235, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7657575, Length=200, Percent_Identity=27.5, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI300797705, Length=188, Percent_Identity=27.6595744680851, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI300797577, Length=249, Percent_Identity=25.3012048192771, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI308199517, Length=240, Percent_Identity=35.8333333333333, Blast_Score=130, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17541892, Length=216, Percent_Identity=31.0185185185185, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71990482, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=264, Percent_Identity=26.1363636363636, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=263, Percent_Identity=28.8973384030418, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=213, Percent_Identity=30.5164319248826, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28571445, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648389, Length=197, Percent_Identity=29.9492385786802, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28571443, Length=119, Percent_Identity=33.6134453781513, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571441, Length=119, Percent_Identity=33.6134453781513, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_MYCPA (Q73WM7)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961567.1
- ProteinModelPortal:   Q73WM7
- SMR:   Q73WM7
- EnsemblBacteria:   EBMYCT00000040107
- GeneID:   2719032
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2633
- NMPDR:   fig|262316.1.peg.2633
- GeneTree:   EBGT00050000016307
- HOGENOM:   HBG641281
- OMA:   FVHEARL
- ProtClustDB:   PRK00481
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25733; Mature: 25733

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLV
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADVAPNAGHRAIAAWQDHAEVSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYT
HHCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPWRRAVEATESADVMVVVGTSA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCEEEEECCCE
IVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN
EEECCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWRDNPQRVWGWYLWRHYLV
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADVAPNAGHRAIAAWQDHAEVSVITQNVDDLHERAGSRPVHHLHGSLFEFRCARCAKPYT
HHCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GELPAMAEPALEVQPPVCGCGGLIRPDIVWFGEQLPDEPWRRAVEATESADVMVVVGTSA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCEEEEECCCE
IVYPAAGLAELALSRGAAVVEVNPEVTPLSASATLSIRETASQALPGLLQRLPALLN
EEECCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA