| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is fadD36
Identifier: 41408678
GI number: 41408678
Start: 2902025
End: 2903446
Strand: Reverse
Name: fadD36
Synonym: MAP2580c
Alternate gene names: 41408678
Gene position: 2903446-2902025 (Counterclockwise)
Preceding gene: 41408679
Following gene: 41408677
Centisome position: 60.12
GC content: 73.98
Gene sequence:
>1422_bases GTGCTGCTGACGTCGCTGAATCCCTCGGCCGTTACCGCCACCGACATCCCCGACGCGGTACGCATCGACGGCACCGTGCT CAGCCGCGCCGACCTGCTCGGCGCCGCGACCTCGGTGGCCGAGCGGGTGGCCGGCGCGGGCCGGGTCGCCGTCCTCGCCA CACCGACCGCCGCCACGGTGCTCGCGGTGACCGGGTGCCTGATCGCCGGGGTGCCGTTCGTCCCGGTGCCCGCCGACGTC GGGGCCGCCGAACGCCGGCACATGCTGGCCGACTCCGGGGTGCGGGCCTGGCTCGGCCCCCTGCCTGACGAGCCCGACGG CCTGCCGCACGTCCCGGTGCGGCTGCACGCCCGCTCCTGGCACCGCTACCCCGAGCCGTCACCGGACGCCACCGCGATGA TCATCTACACCTCGGGCACCACCGGGCTGCCCAAGGGGGTGGTGCTGAGCCGGCGCGCGATCGCCGCCGACCTGGACGCC CTCGCGGAGGCCTGGCAGTGGACGGCCGACGACGTGCTGGTGCACGGGCTGCCGCTGTTTCACGTGCACGGTCTGGTGCT GGGCCTGCTGGGCTCGCTGCGGATCGGGAATCGGTTCGTCCACACCGGAAAACCGACCCCGGCCGGCTACGCGCAGGCCC GCACCGACTTCGGCGGCACCCTGTTCTTCGGGGTGCCGACGGTGTGGTCGCGGGTGGTGGCCGACGATGCGGCCGCCCGC GCGCTGCGCCCGGCGCGGCTGCTGGTCTCCGGCAGCGCGCCGCTGCCGGTCCCGGTGTTCGACCGGTTGGCCGGGCTCAC CGGGCACCAGCCCGTCGAACGCTACGGCGCCTCGGAATCGCTGATCACCATCTCCACCCGGGCCGACGGCGAGCGGCGCC CCGGCTGGGTGGGCCTGCCGCTGACCGGCGTGCAGACCCGGGTGGTCGACGACGACGGCAACCCGGTGCCGCACGACGGG GAGACCGTCGGCAAGCTGCTGGTGCGCGGCCCGATGATGTTCGACGGCTACCTCAACCGGCCCGACGCCACCGCCGAGGC GTTCGACGCCGACGGCTGGTACCGCACCGGCGACGTCGCCGTCGTCGACGACGCCGGCATGCACCGCATCGTCGGGCGGG AGTCCGTCGATCTGATCAAGTCCGGCGGCTACCGCATCGGCGCCGGCGAAATCGAAACCGCGCTGCTCGGCCACCCCGGC GTCGCCGAGGCCGCCGTCGTCGGGATGCCCGACGAGGACCTGGGGCAGCGCATCGTCGCGTTCGTCGTCCCCGCCGGCCG GGTCAACCCCGACGACCTGATCGACCATGTCGCCCAACAACTTTCGATACACAAGCGGCCCCGCGAGGTGCGCGTGGTGG ACGCGCTGCCGCGCAACGCCATGGGCAAGGTGCTCAAGAAGCAGCTGCTGTCCGACGGCTGA
Upstream 100 bases:
>100_bases ACCTCGGCGGGCTGGGCCGCGGCGAGGAGATCCTGTCCACCCTGACCAAGATCTGGGACGAGCAGAACTGACCCGTGCCG GTGGCGGGTAGCCTGCTGGC
Downstream 100 bases:
>100_bases GCGGGCGTCGTGATGCACGACACGCAGCAACTTGCCAGCTTCGGGGCCGAGCGTGGCCGCCACGCTTCACCTACCGTCGT AACCGTGCATTCAGGCAACC
Product: acyl-CoA synthetase
Products: NA
Alternate protein names: Long-chain acyl-CoA synthetase [H]
Number of amino acids: Translated: 473; Mature: 473
Protein sequence:
>473_residues MLLTSLNPSAVTATDIPDAVRIDGTVLSRADLLGAATSVAERVAGAGRVAVLATPTAATVLAVTGCLIAGVPFVPVPADV GAAERRHMLADSGVRAWLGPLPDEPDGLPHVPVRLHARSWHRYPEPSPDATAMIIYTSGTTGLPKGVVLSRRAIAADLDA LAEAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADDAAAR ALRPARLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPGWVGLPLTGVQTRVVDDDGNPVPHDG ETVGKLLVRGPMMFDGYLNRPDATAEAFDADGWYRTGDVAVVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETALLGHPG VAEAAVVGMPDEDLGQRIVAFVVPAGRVNPDDLIDHVAQQLSIHKRPREVRVVDALPRNAMGKVLKKQLLSDG
Sequences:
>Translated_473_residues MLLTSLNPSAVTATDIPDAVRIDGTVLSRADLLGAATSVAERVAGAGRVAVLATPTAATVLAVTGCLIAGVPFVPVPADV GAAERRHMLADSGVRAWLGPLPDEPDGLPHVPVRLHARSWHRYPEPSPDATAMIIYTSGTTGLPKGVVLSRRAIAADLDA LAEAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADDAAAR ALRPARLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPGWVGLPLTGVQTRVVDDDGNPVPHDG ETVGKLLVRGPMMFDGYLNRPDATAEAFDADGWYRTGDVAVVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETALLGHPG VAEAAVVGMPDEDLGQRIVAFVVPAGRVNPDDLIDHVAQQLSIHKRPREVRVVDALPRNAMGKVLKKQLLSDG >Mature_473_residues MLLTSLNPSAVTATDIPDAVRIDGTVLSRADLLGAATSVAERVAGAGRVAVLATPTAATVLAVTGCLIAGVPFVPVPADV GAAERRHMLADSGVRAWLGPLPDEPDGLPHVPVRLHARSWHRYPEPSPDATAMIIYTSGTTGLPKGVVLSRRAIAADLDA LAEAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADDAAAR ALRPARLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPGWVGLPLTGVQTRVVDDDGNPVPHDG ETVGKLLVRGPMMFDGYLNRPDATAEAFDADGWYRTGDVAVVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETALLGHPG VAEAAVVGMPDEDLGQRIVAFVVPAGRVNPDDLIDHVAQQLSIHKRPREVRVVDALPRNAMGKVLKKQLLSDG
Specific function: Involved in the degradation of long-chain fatty acids [H]
COG id: COG0318
COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
Gene ontology:
Cell location: Partially Membrane-Associated [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]
Homologues:
Organism=Homo sapiens, GI187761345, Length=378, Percent_Identity=39.4179894179894, Blast_Score=240, Evalue=2e-63, Organism=Homo sapiens, GI187761343, Length=378, Percent_Identity=39.4179894179894, Blast_Score=240, Evalue=2e-63, Organism=Homo sapiens, GI122937307, Length=365, Percent_Identity=30.4109589041096, Blast_Score=143, Evalue=3e-34, Organism=Homo sapiens, GI157311624, Length=471, Percent_Identity=27.1762208067941, Blast_Score=137, Evalue=2e-32, Organism=Homo sapiens, GI157311622, Length=471, Percent_Identity=27.1762208067941, Blast_Score=137, Evalue=2e-32, Organism=Homo sapiens, GI58082049, Length=471, Percent_Identity=26.7515923566879, Blast_Score=133, Evalue=4e-31, Organism=Homo sapiens, GI42544132, Length=371, Percent_Identity=27.7628032345013, Blast_Score=131, Evalue=1e-30, Organism=Homo sapiens, GI38505220, Length=352, Percent_Identity=30.3977272727273, Blast_Score=123, Evalue=4e-28, Organism=Homo sapiens, GI115511026, Length=475, Percent_Identity=27.3684210526316, Blast_Score=120, Evalue=3e-27, Organism=Homo sapiens, GI40807491, Length=353, Percent_Identity=30.028328611898, Blast_Score=119, Evalue=5e-27, Organism=Homo sapiens, GI156151445, Length=352, Percent_Identity=28.6931818181818, Blast_Score=115, Evalue=8e-26, Organism=Homo sapiens, GI57165412, Length=350, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=6e-24, Organism=Homo sapiens, GI57165410, Length=350, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=6e-24, Organism=Homo sapiens, GI42794756, Length=350, Percent_Identity=28, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI42794760, Length=350, Percent_Identity=28, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI42794758, Length=350, Percent_Identity=28, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI28416953, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=4e-17, Organism=Homo sapiens, GI13375727, Length=375, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=4e-15, Organism=Escherichia coli, GI1788107, Length=361, Percent_Identity=32.6869806094183, Blast_Score=176, Evalue=4e-45, Organism=Escherichia coli, GI145693145, Length=351, Percent_Identity=32.4786324786325, Blast_Score=157, Evalue=1e-39, Organism=Escherichia coli, GI1786810, Length=353, Percent_Identity=32.2946175637394, Blast_Score=138, Evalue=7e-34, Organism=Escherichia coli, GI221142682, Length=443, Percent_Identity=25.7336343115124, Blast_Score=129, Evalue=5e-31, Organism=Escherichia coli, GI1789201, Length=357, Percent_Identity=28.2913165266106, Blast_Score=103, Evalue=3e-23, Organism=Escherichia coli, GI1790505, Length=376, Percent_Identity=27.3936170212766, Blast_Score=94, Evalue=2e-20, Organism=Escherichia coli, GI1786801, Length=302, Percent_Identity=31.1258278145695, Blast_Score=91, Evalue=2e-19, Organism=Escherichia coli, GI1786529, Length=376, Percent_Identity=27.9255319148936, Blast_Score=70, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17558820, Length=493, Percent_Identity=32.4543610547667, Blast_Score=234, Evalue=5e-62, Organism=Caenorhabditis elegans, GI32563687, Length=465, Percent_Identity=30.3225806451613, Blast_Score=204, Evalue=1e-52, Organism=Caenorhabditis elegans, GI17531443, Length=351, Percent_Identity=30.1994301994302, Blast_Score=124, Evalue=1e-28, Organism=Caenorhabditis elegans, GI71994694, Length=363, Percent_Identity=29.7520661157025, Blast_Score=123, Evalue=2e-28, Organism=Caenorhabditis elegans, GI71994703, Length=363, Percent_Identity=29.7520661157025, Blast_Score=123, Evalue=3e-28, Organism=Caenorhabditis elegans, GI71994690, Length=363, Percent_Identity=29.7520661157025, Blast_Score=122, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17557194, Length=386, Percent_Identity=29.2746113989637, Blast_Score=122, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17559526, Length=400, Percent_Identity=28.5, Blast_Score=121, Evalue=8e-28, Organism=Caenorhabditis elegans, GI17538037, Length=386, Percent_Identity=28.7564766839378, Blast_Score=116, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17560308, Length=360, Percent_Identity=28.3333333333333, Blast_Score=108, Evalue=9e-24, Organism=Caenorhabditis elegans, GI17560140, Length=363, Percent_Identity=26.7217630853994, Blast_Score=99, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17556552, Length=382, Percent_Identity=27.7486910994764, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17510401, Length=351, Percent_Identity=27.3504273504274, Blast_Score=97, Evalue=3e-20, Organism=Caenorhabditis elegans, GI71985884, Length=354, Percent_Identity=25.9887005649718, Blast_Score=91, Evalue=9e-19, Organism=Caenorhabditis elegans, GI71996755, Length=361, Percent_Identity=26.5927977839335, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17556356, Length=223, Percent_Identity=26.9058295964126, Blast_Score=71, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6319699, Length=341, Percent_Identity=30.791788856305, Blast_Score=145, Evalue=1e-35, Organism=Saccharomyces cerevisiae, GI6319264, Length=376, Percent_Identity=26.063829787234, Blast_Score=84, Evalue=6e-17, Organism=Saccharomyces cerevisiae, GI6323182, Length=375, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=8e-15, Organism=Saccharomyces cerevisiae, GI6320852, Length=254, Percent_Identity=27.5590551181102, Blast_Score=68, Evalue=2e-12, Organism=Drosophila melanogaster, GI21355181, Length=344, Percent_Identity=31.9767441860465, Blast_Score=141, Evalue=9e-34, Organism=Drosophila melanogaster, GI18859661, Length=354, Percent_Identity=27.9661016949153, Blast_Score=141, Evalue=1e-33, Organism=Drosophila melanogaster, GI24581924, Length=355, Percent_Identity=29.5774647887324, Blast_Score=125, Evalue=6e-29, Organism=Drosophila melanogaster, GI24648260, Length=485, Percent_Identity=27.4226804123711, Blast_Score=120, Evalue=1e-27, Organism=Drosophila melanogaster, GI19922652, Length=364, Percent_Identity=31.043956043956, Blast_Score=117, Evalue=1e-26, Organism=Drosophila melanogaster, GI24653035, Length=434, Percent_Identity=25.8064516129032, Blast_Score=107, Evalue=1e-23, Organism=Drosophila melanogaster, GI221329755, Length=396, Percent_Identity=22.979797979798, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI24656500, Length=363, Percent_Identity=30.5785123966942, Blast_Score=103, Evalue=3e-22, Organism=Drosophila melanogaster, GI161076582, Length=497, Percent_Identity=24.3460764587525, Blast_Score=99, Evalue=4e-21, Organism=Drosophila melanogaster, GI281366413, Length=359, Percent_Identity=28.6908077994429, Blast_Score=96, Evalue=5e-20, Organism=Drosophila melanogaster, GI21356947, Length=347, Percent_Identity=25.6484149855908, Blast_Score=96, Evalue=6e-20, Organism=Drosophila melanogaster, GI24666501, Length=359, Percent_Identity=28.6908077994429, Blast_Score=96, Evalue=7e-20, Organism=Drosophila melanogaster, GI24666497, Length=359, Percent_Identity=28.6908077994429, Blast_Score=96, Evalue=7e-20, Organism=Drosophila melanogaster, GI20130357, Length=485, Percent_Identity=24.9484536082474, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24648257, Length=347, Percent_Identity=25.3602305475504, Blast_Score=86, Evalue=5e-17, Organism=Drosophila melanogaster, GI24648253, Length=482, Percent_Identity=21.7842323651452, Blast_Score=82, Evalue=6e-16, Organism=Drosophila melanogaster, GI24648255, Length=482, Percent_Identity=21.9917012448133, Blast_Score=81, Evalue=1e-15, Organism=Drosophila melanogaster, GI21356441, Length=490, Percent_Identity=22.6530612244898, Blast_Score=80, Evalue=4e-15, Organism=Drosophila melanogaster, GI281365686, Length=321, Percent_Identity=22.1183800623053, Blast_Score=78, Evalue=2e-14, Organism=Drosophila melanogaster, GI21358303, Length=472, Percent_Identity=20.1271186440678, Blast_Score=74, Evalue=3e-13, Organism=Drosophila melanogaster, GI24667959, Length=363, Percent_Identity=25.8953168044077, Blast_Score=69, Evalue=7e-12, Organism=Drosophila melanogaster, GI62472339, Length=363, Percent_Identity=25.8953168044077, Blast_Score=69, Evalue=9e-12, Organism=Drosophila melanogaster, GI24667955, Length=363, Percent_Identity=25.8953168044077, Blast_Score=68, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020459 - InterPro: IPR020845 - InterPro: IPR000873 [H]
Pfam domain/function: PF00501 AMP-binding [H]
EC number: =6.2.1.3 [H]
Molecular weight: Translated: 49826; Mature: 49826
Theoretical pI: Translated: 6.40; Mature: 6.40
Prosite motif: PS00455 AMP_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLLTSLNPSAVTATDIPDAVRIDGTVLSRADLLGAATSVAERVAGAGRVAVLATPTAATV CEEECCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH LAVTGCLIAGVPFVPVPADVGAAERRHMLADSGVRAWLGPLPDEPDGLPHVPVRLHARSW HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEECCCC HRYPEPSPDATAMIIYTSGTTGLPKGVVLSRRAIAADLDALAEAWQWTADDVLVHGLPLF CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHH HVHGLVLGLLGSLRIGNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADDAAAR HHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHHHHH ALRPARLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPGWVGLP HCCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCEEECC LTGVQTRVVDDDGNPVPHDGETVGKLLVRGPMMFDGYLNRPDATAEAFDADGWYRTGDVA CCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCHHHCCCCCCEECCCEE VVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETALLGHPGVAEAAVVGMPDEDLGQRIVA EECCCCCHHHHCCCHHHHHHCCCEEEECCCHHHHCCCCCCCCCEEEECCCCHHHHHEEEE FVVPAGRVNPDDLIDHVAQQLSIHKRPREVRVVDALPRNAMGKVLKKQLLSDG EEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC >Mature Secondary Structure MLLTSLNPSAVTATDIPDAVRIDGTVLSRADLLGAATSVAERVAGAGRVAVLATPTAATV CEEECCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH LAVTGCLIAGVPFVPVPADVGAAERRHMLADSGVRAWLGPLPDEPDGLPHVPVRLHARSW HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEECCCC HRYPEPSPDATAMIIYTSGTTGLPKGVVLSRRAIAADLDALAEAWQWTADDVLVHGLPLF CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHH HVHGLVLGLLGSLRIGNRFVHTGKPTPAGYAQARTDFGGTLFFGVPTVWSRVVADDAAAR HHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHHHHH ALRPARLLVSGSAPLPVPVFDRLAGLTGHQPVERYGASESLITISTRADGERRPGWVGLP HCCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCEEECC LTGVQTRVVDDDGNPVPHDGETVGKLLVRGPMMFDGYLNRPDATAEAFDADGWYRTGDVA CCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCHHHCCCCCCEECCCEE VVDDAGMHRIVGRESVDLIKSGGYRIGAGEIETALLGHPGVAEAAVVGMPDEDLGQRIVA EECCCCCHHHHCCCHHHHHHCCCEEEECCCHHHHCCCCCCCCCEEEECCCCHHHHHEEEE FVVPAGRVNPDDLIDHVAQQLSIHKRPREVRVVDALPRNAMGKVLKKQLLSDG EEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9579061; 9384377 [H]