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The map label for this gene is htrA

Identifier: 41408653

GI number: 41408653

Start: 2872770

End: 2874284

Strand: Reverse

Name: htrA

Synonym: MAP2555c

Alternate gene names: 41408653

Gene position: 2874284-2872770 (Counterclockwise)

Preceding gene: 41408654

Following gene: 41408652

Centisome position: 59.51

GC content: 70.89

Gene sequence:

>1515_bases
GTGACCTCCGACCCAGGCTACGACCAAGCAAAAGACAGCGCCAACCGGTTGGCGCCGCGCCCCATCTCGCGCCCGCCCGT
CGACCCCGCATCGCGCCGGGAGTTCGGCCGGCCCGCCGGGCTGCGGGGATCGTTCGTGGCCGAACGCGTGCGTCCGAAGA
AATACCGCGAGCAGTCGGAGTTCCGGCCGAGCGAGCAGCCGGCCGACCCCGTGCTGCAGGAGGCGTTCAGCCGGCCCGAC
GGCAGCCCGGAGACGCTGCAGCGCCACCCCGTCGACAGCGGCGCGCTGGCGGCCGAGAAGGACGGGGTGGAGCCCGACCA
CGCCGACGACCCGTGGCGTGACCCGGGGGCCCCGGCCGCGTTGGGCACGCCGGCGGTGGCGCCGTCGCCGTCGCGGTCCG
CGCTGGGCTACGGCGGCAAGCTGGGTGTGCGCGACGTGCTCTTCGGCGGCAAGGTGTCCTACCTGGCGTTGCTGGTTCTG
CTGCTGATCGCGCTGGTCATCGGCCTGATCGGCGGTGTGGTCGGCCGCAAGACCGCCGAGGTCGCCGAGGCCTTCACCAC
GTCGAAGGTGACGCTGTCGACGAACGGCAACGGCGAAGCCCCGGCCGGGCGTTTCGCGAAGGTGGCGGCGGCCACCGCGG
GCGCGGTGGTCACCATCGAGTCCAAGAGCGACCAGGAGGGCATGCAGGGCTCGGGCGTCGTCATCGACGGCCGCGGCTAC
ATCGTCACCAACAACCACGTCATCTCCGAGGCGGCGAACAACCCCAGCCAGTTCAAGACCACCGTGGTGTTCAACGACGG
CAAGGAGGTGCCCGCCAACCTGGTCGGCCGCGACCCCAAGACCGACCTGGCCGTGCTGAAGGTGGACAACGTCGACAATC
TGTCGGTGGCCCGGCTCGGTGACTCCGACAAGGTGCGGGTCGGCGACGAGGTGCTGGCCGCGGGCGCGCCGCTGGGGCTG
CGCAGCACCGTGACGCACGGCATCGTCAGCGCCCTGCACCGGCCGGTCCCGCTGTCCGGGGAGGGCTCGGACACCGACAC
GGTGATCGACGCCGTGCAGACCGACGCGTCGATCAACCACGGCAACTCCGGCGGCCCGTTGATCGACATGAATTCCCAGG
TGATCGGCATCGACACCGCGGGTAAGTCGTTGTCCGACAGCGCAAGTGGGCTGGGCTTCGCGATCCCCATCAACGAGGCC
AAGGAGGTCGCCCAGACCTTGATCAGGGACGGCAAGATCGTGCACCCGACGCTGGGGGTCAGCACCCGCTCGGTGAGCAA
CGCGATCGCCTCCGGCGCGCAGGTGGCCAACGTGAAGGCGGGCAGCCCCGCGCAGAAGGGCGGCGTCCTGGAGAACGACG
TCGTGGTCAAGGTGGGCAACCGCAAGGTCGCCGACGCCGACGAGTTCGTGGTCGCGGTGCGGCAGCTGACCATCGGCCAG
GATTCCCCGATCGAGGTGGTGCGCGACGGCCGCCACGTCACCCTGACGGTGAAGCCGGACCCGGACGGCAGCTGA

Upstream 100 bases:

>100_bases
CCGTGGATACTAGGGTGGACACGGACAACGCCGGTGCCGCGTAAATCGCCCGGTAAAGGCCTGTCTCGAGCGCTCAAATC
GAGGATCCAAAAGGGATAAC

Downstream 100 bases:

>100_bases
TGCTCGGCAGTCTGAGCTGGGAGCACATGCTGGTCCTCGTGGTGGTGGGCCTGGTGGTGCTCGGGCCGGAGCGGCTGCCG
GGCGCCATCCGGTGGACGTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTSDPGYDQAKDSANRLAPRPISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSEFRPSEQPADPVLQEAFSRPD
GSPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAALGTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVL
LLIALVIGLIGGVVGRKTAEVAEAFTTSKVTLSTNGNGEAPAGRFAKVAAATAGAVVTIESKSDQEGMQGSGVVIDGRGY
IVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLSVARLGDSDKVRVGDEVLAAGAPLGL
RSTVTHGIVSALHRPVPLSGEGSDTDTVIDAVQTDASINHGNSGGPLIDMNSQVIGIDTAGKSLSDSASGLGFAIPINEA
KEVAQTLIRDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADADEFVVAVRQLTIGQ
DSPIEVVRDGRHVTLTVKPDPDGS

Sequences:

>Translated_504_residues
MTSDPGYDQAKDSANRLAPRPISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSEFRPSEQPADPVLQEAFSRPD
GSPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAALGTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVL
LLIALVIGLIGGVVGRKTAEVAEAFTTSKVTLSTNGNGEAPAGRFAKVAAATAGAVVTIESKSDQEGMQGSGVVIDGRGY
IVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLSVARLGDSDKVRVGDEVLAAGAPLGL
RSTVTHGIVSALHRPVPLSGEGSDTDTVIDAVQTDASINHGNSGGPLIDMNSQVIGIDTAGKSLSDSASGLGFAIPINEA
KEVAQTLIRDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADADEFVVAVRQLTIGQ
DSPIEVVRDGRHVTLTVKPDPDGS
>Mature_503_residues
TSDPGYDQAKDSANRLAPRPISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSEFRPSEQPADPVLQEAFSRPDG
SPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAALGTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVLL
LIALVIGLIGGVVGRKTAEVAEAFTTSKVTLSTNGNGEAPAGRFAKVAAATAGAVVTIESKSDQEGMQGSGVVIDGRGYI
VTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLSVARLGDSDKVRVGDEVLAAGAPLGLR
STVTHGIVSALHRPVPLSGEGSDTDTVIDAVQTDASINHGNSGGPLIDMNSQVIGIDTAGKSLSDSASGLGFAIPINEAK
EVAQTLIRDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADADEFVVAVRQLTIGQD
SPIEVVRDGRHVTLTVKPDPDGS

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=294, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4506141, Length=325, Percent_Identity=32.3076923076923, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI7019477, Length=328, Percent_Identity=30.1829268292683, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI24308541, Length=290, Percent_Identity=30.6896551724138, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789629, Length=284, Percent_Identity=37.6760563380282, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=34.8920863309352, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=36.5591397849462, Blast_Score=148, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646839, Length=330, Percent_Identity=29.6969696969697, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 52155; Mature: 52024

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDPGYDQAKDSANRLAPRPISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSE
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHH
FRPSEQPADPVLQEAFSRPDGSPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAA
CCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LGTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVLLLIALVIGLIGGVVGRKTAE
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VAEAFTTSKVTLSTNGNGEAPAGRFAKVAAATAGAVVTIESKSDQEGMQGSGVVIDGRGY
HHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
IVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLSVARLG
EEECCEEEECCCCCCCCEEEEEEEECCCCCCHHHCCCCCCCCEEEEEECCCCCCEEEECC
DSDKVRVGDEVLAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAVQTDASINH
CCCCEEECHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC
GNSGGPLIDMNSQVIGIDTAGKSLSDSASGLGFAIPINEAKEVAQTLIRDGKIVHPTLGV
CCCCCCEEECCCCEEEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCEECCCCCC
STRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADADEFVVAVRQLTIGQ
CHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
DSPIEVVRDGRHVTLTVKPDPDGS
CCCHHHEECCCEEEEEECCCCCCC
>Mature Secondary Structure 
TSDPGYDQAKDSANRLAPRPISRPPVDPASRREFGRPAGLRGSFVAERVRPKKYREQSE
CCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHH
FRPSEQPADPVLQEAFSRPDGSPETLQRHPVDSGALAAEKDGVEPDHADDPWRDPGAPAA
CCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LGTPAVAPSPSRSALGYGGKLGVRDVLFGGKVSYLALLVLLLIALVIGLIGGVVGRKTAE
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VAEAFTTSKVTLSTNGNGEAPAGRFAKVAAATAGAVVTIESKSDQEGMQGSGVVIDGRGY
HHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
IVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLSVARLG
EEECCEEEECCCCCCCCEEEEEEEECCCCCCHHHCCCCCCCCEEEEEECCCCCCEEEECC
DSDKVRVGDEVLAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAVQTDASINH
CCCCEEECHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC
GNSGGPLIDMNSQVIGIDTAGKSLSDSASGLGFAIPINEAKEVAQTLIRDGKIVHPTLGV
CCCCCCEEECCCCEEEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCEECCCCCC
STRSVSNAIASGAQVANVKAGSPAQKGGVLENDVVVKVGNRKVADADEFVVAVRQLTIGQ
CHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
DSPIEVVRDGRHVTLTVKPDPDGS
CCCHHHEECCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]