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The map label for this gene is mdh

Identifier: 41408639

GI number: 41408639

Start: 2858238

End: 2859227

Strand: Reverse

Name: mdh

Synonym: MAP2541c

Alternate gene names: 41408639

Gene position: 2859227-2858238 (Counterclockwise)

Preceding gene: 41408642

Following gene: 41408638

Centisome position: 59.2

GC content: 69.49

Gene sequence:

>990_bases
GTGAGCGCAAGTCCTCTCAAGGTTGCCGTCACCGGCGCCGCCGGCCAGATCGGCTACAGCCTGTTGTTCCGCCTGGCCAG
CGGCTCGTTGCTGGGCCCCGACCGCCCGATCGAGCTGCGTCTGCTCGAGATCGAGCCCGCGCTCAAGGCGCTCGAGGGCG
TCGTGATGGAACTCGACGACTGCGCCTTCCCGCTGCTGTCCGGCGTCGAGATCGGCGCCGACCCGAACAAGATCTTCGAC
GGCGCCAACCTCGCGCTGCTGGTCGGCGCGCGGCCGCGCGGCCCGGGCATGGAGCGCAGCGACCTGCTGGAGGCCAACGG
CGCGATCTTCACCGCGCAGGGCAAGGCGCTCAACGAGGTGGCCGCCGACGACATCCGCGTCGGCGTGACCGGCAACCCGG
CCAACACCAACGCGTTGATCGCGATGAGCAACGCCCCGGACATCCCGCGCGAGCGGTTCTCGGCGCTGACCCGCCTGGAC
CACAACCGGGCCATCTCGCAGCTGGCCAAAAAGACCGGCGCCAAGGTCACCGACATCAAGAAGATGACGATCTGGGGCAA
CCACTCCGCCACCCAGTACCCCGATATCTTCCACGCCGAGGTCAAGGGTAAGAACGCGGCCGAGGTGGTGGGCGACCAGA
ACTGGATCGAGAACGACTTCATCCCGACCGTGGCCAAGCGCGGCGCGGCCATCATCGACGCGCGGGGCGCCTCCTCGGCC
GCGTCGGCCGCCTCGGCGACCACCGACGCCGCCCGCGACTGGCTGCTGGGCACCCCGGCGGGCGACTGGGTCTCCATGGC
CGTCATCTCCGACGGCTCCTACGGCGTGCCGGAGGGGCTGATCTCGTCGTTCCCGGTGACCACCAAGGACGGCGACTGGA
CCATCGTGCAGGGCCTGGAGATCGACGAGTTCTCCCGCAGCCGGATCGACAAGACCACCGCCGAGCTCGCCGACGAGCGC
AACGCGGTGACCCAGCTCGGCCTGATCTAA

Upstream 100 bases:

>100_bases
GCCCTGGTAGCGGACCGGAGATCGGCGGCAAAGAAGGGTGCGCTAGTTTCGAGCGGAACCCGAATCTGCACGAACTTCTC
CACACAAGGGGTACATCGAC

Downstream 100 bases:

>100_bases
GACCGACGTGGGCAATTAGGACTACTTATGGGTAGCCCTTACCCTGAAGCGCGTGTCCGAATTGCTTGAATCGATACAGA
GTCGCGCCGAGCAGGGCGCG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDDCAFPLLSGVEIGADPNKIFD
GANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMSNAPDIPRERFSALTRLD
HNRAISQLAKKTGAKVTDIKKMTIWGNHSATQYPDIFHAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSA
ASAASATTDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQGLEIDEFSRSRIDKTTAELADER
NAVTQLGLI

Sequences:

>Translated_329_residues
MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDDCAFPLLSGVEIGADPNKIFD
GANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMSNAPDIPRERFSALTRLD
HNRAISQLAKKTGAKVTDIKKMTIWGNHSATQYPDIFHAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSA
ASAASATTDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQGLEIDEFSRSRIDKTTAELADER
NAVTQLGLI
>Mature_328_residues
SASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDDCAFPLLSGVEIGADPNKIFDG
ANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMSNAPDIPRERFSALTRLDH
NRAISQLAKKTGAKVTDIKKMTIWGNHSATQYPDIFHAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSAA
SAASATTDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQGLEIDEFSRSRIDKTTAELADERN
AVTQLGLI

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family [H]

Homologues:

Organism=Homo sapiens, GI5174539, Length=330, Percent_Identity=52.1212121212121, Blast_Score=340, Evalue=9e-94,
Organism=Homo sapiens, GI89886456, Length=330, Percent_Identity=24.8484848484848, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561064, Length=327, Percent_Identity=54.7400611620795, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI32566798, Length=266, Percent_Identity=53.3834586466165, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI32566800, Length=171, Percent_Identity=54.9707602339181, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24583394, Length=323, Percent_Identity=51.702786377709, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR001252
- InterPro:   IPR010945
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 34632; Mature: 34500

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00068 MDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDD
CCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHH
CAFPLLSGVEIGADPNKIFDGANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEV
HHHHHHCCEEECCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHH
AADDIRVGVTGNPANTNALIAMSNAPDIPRERFSALTRLDHNRAISQLAKKTGAKVTDIK
CCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
KMTIWGNHSATQYPDIFHAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSA
EEEEECCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCCCCH
ASAASATTDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQGLE
HHHHHHHHHHHHHCEEECCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCC
IDEFSRSRIDKTTAELADERNAVTQLGLI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALKALEGVVMELDD
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHH
CAFPLLSGVEIGADPNKIFDGANLALLVGARPRGPGMERSDLLEANGAIFTAQGKALNEV
HHHHHHCCEEECCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHH
AADDIRVGVTGNPANTNALIAMSNAPDIPRERFSALTRLDHNRAISQLAKKTGAKVTDIK
CCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
KMTIWGNHSATQYPDIFHAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSA
EEEEECCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCCCCH
ASAASATTDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQGLE
HHHHHHHHHHHHHCEEECCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCC
IDEFSRSRIDKTTAELADERNAVTQLGLI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA