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The map label for this gene is maeB [C]

Identifier: 41408638

GI number: 41408638

Start: 2856983

End: 2858194

Strand: Reverse

Name: maeB [C]

Synonym: MAP2540c

Alternate gene names: 41408638

Gene position: 2858194-2856983 (Counterclockwise)

Preceding gene: 41408639

Following gene: 41408637

Centisome position: 59.18

GC content: 70.13

Gene sequence:

>1212_bases
CTGAAGCGCGTGTCCGAATTGCTTGAATCGATACAGAGTCGCGCCGAGCAGGGCGCGATCACGGACGCCGAGATCTTCGC
GGCACACGTCGGCGGCAAGCTGTCGGTCAGCCTGACCTCCCCGCTGGACACCCAGCGCGCGCTGTCGATCGCCTACACCC
CGGGCGTGGCGCAGGTCAGCCGGGCGATCGCCGCCGACCACCGTCAAGCGGCGCACTACACCTGGGCCAACCGGCTGGTG
GCCGTGGTCAGCGACGGCAGCGCGGTGCTCGGCCTGGGCGACATCGGTCCCGCGGCGTCGCTGCCGGTGATGGAGGGCAA
GTGCGCCCTGTTCCAGGCGTACGGCGGGCTGAACGCCATCCCGATCGTGCTGGATACCAAGGATCCCGACGAGATCGTGG
AGACCCTGGTGCGGCTGCGCCCCACCTTCGGCGCCGTCAACCTCGAGGACATCTCCGCGCCGCGCTGCTTCGAGATCGAA
CGCCGACTCATCGAGGCGCTGGACTGCCCGGTGATGCACGACGACCAGCACGGCACCGCGATCGTCGTGCTGGCCGCCCT
GATGGGGGCCAGCAAGCTGCTGGGCCGGGACATGAGCTCGCTGAAGGTGGTGGTGTCCGGAGCCGGGGCGGCCGGCGTCG
CGTGCACCAATCTCCTTATGGCGATGGGTGTTTCGGACATCACCGTGCTCGACTCGCGGGGAATCCTGCACGCCGGCCGC
GACGACATGAACGACGTCAAGGCGGCGTTGTCGCGGCGCACCAACCCGGCCGGCCTGACCGGCAGCCTGGCCGAGGCGAT
CCGCGGCGCCGACGTGTTCCTGGGGCTGTCGGGGGGTGTGGTGCCCGAGGAGATGATCGCGGCCATGGCGCCCAATGGGA
TCGTGTTCGCGCTGTCCAACCCCGACCCGGAGATCCATCCGCAGATCGCGGCGAAGTACGCCACCGTGGTGGCCACCGGG
CGCAGCGATTTCCCCAACCAGATCAACAACGTGCTGGCGTTCCCCGGGGTGTTCCGCGGCGCGCTGGAGGCCGGCGCCCG
CCGGATCACCGAGAAGATGATGGTCGCCGCGGCCGAGGCGATCTTCTCCGTCGTCAGCGACGACCTCGCGCCCGATCGGA
TCGTGCCCAGCCCGCTGGACACCCGGGTCGGGGACGCGGTCGCCACCGCGGTGGCGCTGGCCACAGAAGTTTCCGACGCT
CCCGCCGGGTGA

Upstream 100 bases:

>100_bases
ACCACCGCCGAGCTCGCCGACGAGCGCAACGCGGTGACCCAGCTCGGCCTGATCTAAGACCGACGTGGGCAATTAGGACT
ACTTATGGGTAGCCCTTACC

Downstream 100 bases:

>100_bases
GAATCGGCAGGCTGGTCGCGCCGCTGCTGACCGCCCTACTTGCCGTCACCGGCTGCACGACCGACACCGGCGACCGTCGC
GCCCACGCCGAGGTGGTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRVSELLESIQSRAEQGAITDAEIFAAHVGGKLSVSLTSPLDTQRALSIAYTPGVAQVSRAIAADHRQAAHYTWANRLV
AVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIE
RRLIEALDCPVMHDDQHGTAIVVLAALMGASKLLGRDMSSLKVVVSGAGAAGVACTNLLMAMGVSDITVLDSRGILHAGR
DDMNDVKAALSRRTNPAGLTGSLAEAIRGADVFLGLSGGVVPEEMIAAMAPNGIVFALSNPDPEIHPQIAAKYATVVATG
RSDFPNQINNVLAFPGVFRGALEAGARRITEKMMVAAAEAIFSVVSDDLAPDRIVPSPLDTRVGDAVATAVALATEVSDA
PAG

Sequences:

>Translated_403_residues
MKRVSELLESIQSRAEQGAITDAEIFAAHVGGKLSVSLTSPLDTQRALSIAYTPGVAQVSRAIAADHRQAAHYTWANRLV
AVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIE
RRLIEALDCPVMHDDQHGTAIVVLAALMGASKLLGRDMSSLKVVVSGAGAAGVACTNLLMAMGVSDITVLDSRGILHAGR
DDMNDVKAALSRRTNPAGLTGSLAEAIRGADVFLGLSGGVVPEEMIAAMAPNGIVFALSNPDPEIHPQIAAKYATVVATG
RSDFPNQINNVLAFPGVFRGALEAGARRITEKMMVAAAEAIFSVVSDDLAPDRIVPSPLDTRVGDAVATAVALATEVSDA
PAG
>Mature_403_residues
MKRVSELLESIQSRAEQGAITDAEIFAAHVGGKLSVSLTSPLDTQRALSIAYTPGVAQVSRAIAADHRQAAHYTWANRLV
AVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIE
RRLIEALDCPVMHDDQHGTAIVVLAALMGASKLLGRDMSSLKVVVSGAGAAGVACTNLLMAMGVSDITVLDSRGILHAGR
DDMNDVKAALSRRTNPAGLTGSLAEAIRGADVFLGLSGGVVPEEMIAAMAPNGIVFALSNPDPEIHPQIAAKYATVVATG
RSDFPNQINNVLAFPGVFRGALEAGARRITEKMMVAAAEAIFSVVSDDLAPDRIVPSPLDTRVGDAVATAVALATEVSDA
PAG

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=426, Percent_Identity=26.056338028169, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62420882, Length=428, Percent_Identity=26.8691588785047, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI62420880, Length=428, Percent_Identity=26.8691588785047, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI239049447, Length=428, Percent_Identity=26.8691588785047, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4505145, Length=372, Percent_Identity=27.1505376344086, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI270265879, Length=331, Percent_Identity=26.8882175226586, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=391, Percent_Identity=45.5242966751918, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17537199, Length=448, Percent_Identity=24.1071428571429, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=345, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646388, Length=374, Percent_Identity=29.6791443850267, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646386, Length=374, Percent_Identity=29.6791443850267, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363503, Length=405, Percent_Identity=25.4320987654321, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78707232, Length=405, Percent_Identity=25.4320987654321, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363505, Length=405, Percent_Identity=25.4320987654321, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78707236, Length=405, Percent_Identity=25.4320987654321, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281362672, Length=347, Percent_Identity=25.6484149855908, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362674, Length=347, Percent_Identity=25.6484149855908, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356279, Length=347, Percent_Identity=25.6484149855908, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78707242, Length=360, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI78707238, Length=360, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI78707240, Length=360, Percent_Identity=25, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 41772; Mature: 41772

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVSELLESIQSRAEQGAITDAEIFAAHVGGKLSVSLTSPLDTQRALSIAYTPGVAQVS
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHHHEEEEECCCHHHHH
RAIAADHRQAAHYTWANRLVAVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAI
HHHHHHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCEE
PIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRLIEALDCPVMHDDQHGTA
EEEEECCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHH
IVVLAALMGASKLLGRDMSSLKVVVSGAGAAGVACTNLLMAMGVSDITVLDSRGILHAGR
HHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCEECCC
DDMNDVKAALSRRTNPAGLTGSLAEAIRGADVFLGLSGGVVPEEMIAAMAPNGIVFALSN
CCHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECC
PDPEIHPQIAAKYATVVATGRSDFPNQINNVLAFPGVFRGALEAGARRITEKMMVAAAEA
CCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IFSVVSDDLAPDRIVPSPLDTRVGDAVATAVALATEVSDAPAG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRVSELLESIQSRAEQGAITDAEIFAAHVGGKLSVSLTSPLDTQRALSIAYTPGVAQVS
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHHHEEEEECCCHHHHH
RAIAADHRQAAHYTWANRLVAVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAI
HHHHHHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCEE
PIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRLIEALDCPVMHDDQHGTA
EEEEECCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHH
IVVLAALMGASKLLGRDMSSLKVVVSGAGAAGVACTNLLMAMGVSDITVLDSRGILHAGR
HHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCEECCC
DDMNDVKAALSRRTNPAGLTGSLAEAIRGADVFLGLSGGVVPEEMIAAMAPNGIVFALSN
CCHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECC
PDPEIHPQIAAKYATVVATGRSDFPNQINNVLAFPGVFRGALEAGARRITEKMMVAAAEA
CCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IFSVVSDDLAPDRIVPSPLDTRVGDAVATAVALATEVSDAPAG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]