Click here to switch to the map view.

The map label for this gene is ddn [H]

Identifier: 41408572

GI number: 41408572

Start: 2779482

End: 2779946

Strand: Reverse

Name: ddn [H]

Synonym: MAP2474c

Alternate gene names: 41408572

Gene position: 2779946-2779482 (Counterclockwise)

Preceding gene: 41408575

Following gene: 41408568

Centisome position: 57.56

GC content: 69.03

Gene sequence:

>465_bases
TTGATGCGCCGCTTCGCGTCCACGACCGCCGGCGTGGCGCTGCTGCGCCCGACGGCGCATAACCTCGACCGCCTCGTCGC
TAAGGCCACCGGCGGGCGGAGCAGCTTCGCCGGGTTGGCAACCGGCATCCCGGTGATCATGCTCACCACGACCGGCGCCA
AATCCGGTGAGCCGCGCACCGTCCCCGTGTACGGGATTCCGCATCCCGAGGGCCTGGCCCTGATCGCGTCCAACTTCGGC
GGCGCCAAGCATCCGGCCTGGTATTTCAACCTCAAGGCCCACCCGGAAGCGACGGTCACGGTCGGGCGCGACAGCTGGCC
TGCCACCGCACGGCTGGCCACGCCCGACGAGCGCGACCAGATCTGGGCCAAAGGTGTCGAGCTGTATCCAGGTTGGCGAA
AATACGAGGTGCGGGCCGGCGATCGCCATATCGAGGCGTTCATCCTGAGCCGGGCGCCGGCCTAA

Upstream 100 bases:

>100_bases
CACGCCCCGGTCGGGCCAAAACGCCCCTCGGCGCCGTCCGGCGAGTCACACTGAGGCCATGTCCGGGCGATCGTTCGACG
ATGCGAATGCTTTTCACCGG

Downstream 100 bases:

>100_bases
TCCCTCACGGGCGCTTCGCGTTTGGTAGGCCGCCGCCGACGCTGGTTTCGTATGGCTATGCACACGTCCCGACAACAATG
ACTGCCGCAGAAATCTCCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MMRRFASTTAGVALLRPTAHNLDRLVAKATGGRSSFAGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFG
GAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQIWAKGVELYPGWRKYEVRAGDRHIEAFILSRAPA

Sequences:

>Translated_154_residues
MMRRFASTTAGVALLRPTAHNLDRLVAKATGGRSSFAGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFG
GAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQIWAKGVELYPGWRKYEVRAGDRHIEAFILSRAPA
>Mature_154_residues
MMRRFASTTAGVALLRPTAHNLDRLVAKATGGRSSFAGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFG
GAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQIWAKGVELYPGWRKYEVRAGDRHIEAFILSRAPA

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 16602; Mature: 16602

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRFASTTAGVALLRPTAHNLDRLVAKATGGRSSFAGLATGIPVIMLTTTGAKSGEPRT
CCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEEECCCCCCCCCE
VPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQ
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCCEEEECCCCCHHH
IWAKGVELYPGWRKYEVRAGDRHIEAFILSRAPA
HHHCCEEECCCCEEEEEECCCCEEEEEEEECCCC
>Mature Secondary Structure
MMRRFASTTAGVALLRPTAHNLDRLVAKATGGRSSFAGLATGIPVIMLTTTGAKSGEPRT
CCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEEECCCCCCCCCE
VPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQ
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCCEEEECCCCCHHH
IWAKGVELYPGWRKYEVRAGDRHIEAFILSRAPA
HHHCCEEECCCCEEEEEECCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]