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The map label for this gene is fadA3

Identifier: 41408505

GI number: 41408505

Start: 2703305

End: 2704525

Strand: Reverse

Name: fadA3

Synonym: MAP2407c

Alternate gene names: 41408505

Gene position: 2704525-2703305 (Counterclockwise)

Preceding gene: 41408506

Following gene: 41408504

Centisome position: 56.0

GC content: 71.09

Gene sequence:

>1221_bases
GTGAGCGCGGTCCGCGAAGCCGTCATCTGCGAGCCCGTCCGGACGCCGATCGGCCGCTACGGGGGAATGTTCAAGGCGCT
CACCGCCGTCGACCTCGGCGTCGCGGCGCTCGGTGGGCTGTTGCAGCGAACCGGGTTGCCCCCCGAGGCCGTGCAGGACG
TCATTCTCGGGCACTGCTATCCCAGCAGCGAGGCGCCGGCGATCGGACGCGTCGTGGCGCTGGATTCCGGTCTGCCGGTG
ACGGTTCCGGGCATGCAGGTCGACCGGCGCTGCGGCTCGGGACTGCAAGCCGTGATCCAGGCCTGCCTGCAGGTGCGCAA
CGGCGATCACGATCTGGTCATCGCCGGCGGCTGCGAAAGCATGAGCAACGTCGCCTTCTACTCCACCGACATGCGCTGGG
GCGGCGCCCGCAGCGGTGTGCGGGTGCATGACGGGCTGGCCCGCGGACGCACCACGGCCGGGGGCCGGCGCTACCCGGTG
CCCGGCGGCATGCTGGAAACGGCCGAGAATCTGCGCCGCCAGTACGGCATTTCCCGCCAGGAGCAGGACGAGCTGGCGGT
GCGGTCACACCAGCGCGCGGTGGCCGCGCAGAAAGACGGCATCCTGGCCCAGGAGATCATCGCCGTCGCGGTGCCCACCC
GGCACGGCGACGAGCTGATCGACACCGACGAACACCCGCGCGCGGATACCTCGGTGGAGTCGCTGAGCAAGCTCAAACCC
GTTCTGCTGGACCAGGATCCAGAGGCCACCGTCACGGCGGGCAACGCCAGCGGGCAGAACGACGTGGCCTCGATGTGCGT
GGTGACCACGCCGGAGAAGGCCGACGAGCACGGCCTGAGGCCATTGGTGCGGCTGGTGTCGTGGGCAGTGGCCGGGGTCG
CCCCTCACATCATGGGCATCGGGCCGGTCCCGGCCACCGAGGTGGCGCTGGCCAAGGCGGGGCTGTCACTGTCCGACATC
GACCTCATCGAGCTCAACGAAGCCTTTGCCGCGCAAGCGCTTGCGGTGATGCGGGAATGGAAGTTCGGCGCCGCCGACCA
CGACCGCACCAATGTGCACGGCTCCGGGATCTCCCTGGGCCATCCGGTCGGCGCCACCGGCGGCCGGATGCTGGCCACCC
TGGCACGCGAGCTCACCCGCCGCCAGGCCCGCTACGGCCTGGAGACGATGTGCATCGGCGGCGGCCAGGGCCTGGCCGCC
GCCTTCGAGCGGGTCGCCTGA

Upstream 100 bases:

>100_bases
GCGAGCCCAGCGAGGTCGCCAGCGTGGCGCTGTTTTTGGCCTCCGACATGTCGTCGTACATGACCGGCACCGTCATGGAG
ATCACGGGCGGCCGGCACCT

Downstream 100 bases:

>100_bases
GATGACCGATCCGCGGCTGCCCCTGCACGGCCTCAGTGTGGTGGAGGTGTCCAGCTTCGTCGCCGCGCCGTTGTGCGGCA
TGACGCTGAGTCAGCTCGGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSAVREAVICEPVRTPIGRYGGMFKALTAVDLGVAALGGLLQRTGLPPEAVQDVILGHCYPSSEAPAIGRVVALDSGLPV
TVPGMQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWGGARSGVRVHDGLARGRTTAGGRRYPV
PGGMLETAENLRRQYGISRQEQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLSKLKP
VLLDQDPEATVTAGNASGQNDVASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDI
DLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAA
AFERVA

Sequences:

>Translated_406_residues
MSAVREAVICEPVRTPIGRYGGMFKALTAVDLGVAALGGLLQRTGLPPEAVQDVILGHCYPSSEAPAIGRVVALDSGLPV
TVPGMQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWGGARSGVRVHDGLARGRTTAGGRRYPV
PGGMLETAENLRRQYGISRQEQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLSKLKP
VLLDQDPEATVTAGNASGQNDVASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDI
DLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAA
AFERVA
>Mature_405_residues
SAVREAVICEPVRTPIGRYGGMFKALTAVDLGVAALGGLLQRTGLPPEAVQDVILGHCYPSSEAPAIGRVVALDSGLPVT
VPGMQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWGGARSGVRVHDGLARGRTTAGGRRYPVP
GGMLETAENLRRQYGISRQEQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLSKLKPV
LLDQDPEATVTAGNASGQNDVASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDID
LIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAAA
FERVA

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=408, Percent_Identity=40.1960784313725, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=39.7022332506204, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI4501853, Length=406, Percent_Identity=38.1773399014778, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=34.0740740740741, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=33.2552693208431, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI194353979, Length=400, Percent_Identity=27.5, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=44.0677966101695, Blast_Score=284, Evalue=6e-78,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=42.4317617866005, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=41.9354838709677, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI48994986, Length=411, Percent_Identity=39.4160583941606, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788683, Length=415, Percent_Identity=33.2530120481928, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=40.8866995073892, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=34.1584158415842, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=31.9796954314721, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=31.6784869976359, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=27.5949367088608, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=33.5820895522388, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=410, Percent_Identity=31.7073170731707, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=38.6699507389163, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI17648125, Length=409, Percent_Identity=38.8753056234719, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=31.4356435643564, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=32.1596244131455, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42659; Mature: 42528

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVREAVICEPVRTPIGRYGGMFKALTAVDLGVAALGGLLQRTGLPPEAVQDVILGHCY
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
PSSEAPAIGRVVALDSGLPVTVPGMQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCES
CCCCCCCCEEEEEECCCCCEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCC
MSNVAFYSTDMRWGGARSGVRVHDGLARGRTTAGGRRYPVPGGMLETAENLRRQYGISRQ
CCCEEEEECCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLSKLKP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
VLLDQDPEATVTAGNASGQNDVASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGI
HHCCCCCCCEEEECCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
GPVPATEVALAKAGLSLSDIDLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLG
CCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
HPVGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAAAFERVA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SAVREAVICEPVRTPIGRYGGMFKALTAVDLGVAALGGLLQRTGLPPEAVQDVILGHCY
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
PSSEAPAIGRVVALDSGLPVTVPGMQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCES
CCCCCCCCEEEEEECCCCCEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCC
MSNVAFYSTDMRWGGARSGVRVHDGLARGRTTAGGRRYPVPGGMLETAENLRRQYGISRQ
CCCEEEEECCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLSKLKP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
VLLDQDPEATVTAGNASGQNDVASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGI
HHCCCCCCCEEEECCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
GPVPATEVALAKAGLSLSDIDLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLG
CCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
HPVGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAAAFERVA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]