Click here to switch to the map view.

The map label for this gene is pdhA

Identifier: 41408407

GI number: 41408407

Start: 2589104

End: 2590195

Strand: Reverse

Name: pdhA

Synonym: MAP2309c

Alternate gene names: 41408407

Gene position: 2590195-2589104 (Counterclockwise)

Preceding gene: 41408408

Following gene: 41408406

Centisome position: 53.63

GC content: 68.86

Gene sequence:

>1092_bases
ATGGCGCAGACATCTCAGCCGCCGATGACCGTCGACTTGCAACCGGTGCAACTCGTCGCCGCCGACGGCACCCCGACCCC
CGAACATCGCTACAGCCGTGAGCTTCCCGCGGAGACGCTGAGCTGGCTCTACGAGATGATGGTGCTCACCCGCGAGCTCG
ACGGCGAATTCGTGAACCTCAAACGCCAAGGCCAGTTGGCGCTGTTCGCGTCCTGCCGCGGCCAGGAAGCCGCTCAGGTG
GGCGCGACTGCCTGCCTGCGCAAAACCGACTGGTTGTTCCCCCAATACCGGGAACTCGGCGCCTTTTTGGTGCGCGGCAT
CCCGCCCGGCAACGTCGGGGCGGTGTGGCGCGGAACGTGGCACGGCGGACTGGGATTCACCGACAAGTGCTGCGCTCCGC
TGTCCATCCCGATCGGCACCCAAAGCCTGCACGCGGTGGGCGCGGCGATGGCCGCCCAACGGCTGGGCGAAGATTCGGTG
ACGATCGCGTTCCTGGGCGACGGAGCCACCAGTGTGGGCGACGTGCACGAGGCGCTGAACTTCGCCGCCGTGTTCCGCAC
ACCCTGCGTGTTCTTCGTGCAGAACAACCAGTGGGCGATCTCCCTGCCGGTCGCCAAACAGACCGCCGCCCCGTCGTTGG
CGCACAAGGCAATTGGCTACGGGATGCCCGGCATCCGGGTGGACGGCAATGACGTGCTGGCCTGCTACGCGGTGACGGCC
GAGGCCGCCGCCCGGGCCCGCGCCGGGCGCGGCCCGACGTTGATCGAGGCGATCACCTACCGGCTGGGGCCGCACACCAC
CTCCGATGACCCGACCCGGTACCGGACACAGGACGAGGTCGACCACTGGGCCGCGCTGGACCCGATCCCGCGCTACCGCA
GCTACCTGCAGGGCCAGGGCCTGTGGTCGGAGCGCTTGGAGGAGCGGGTGATCGGGCGCGCCACGCGGATGCGCGCCGAG
CTGCGCGACGCGGTGTTCGATGCGCCCGATCTCGACGTCGACGAGGTGTTCACCGCGGTGTACGCCGAAATCACGCCGGA
GCTGCAGGCGCAGCGCCGTGCGCTGCGGACCGAACTCGAGAAAAGTGATTGA

Upstream 100 bases:

>100_bases
GCGCATAATGGTGAGTACGCCAGTGTCGCGGCGAGCGAAGCCTTTCGTGTAGCTGGCGATCGACTTCCGCTCGCGGTATG
CACCGAGCAAGGGAGGCGGT

Downstream 100 bases:

>100_bases
GAGATGACCCAGCTCGCTGATCGCCCGACCGGCCACGGCGAAACCCTCACCGCGGCAGTGCAGGATGTCGCGCTGCACGC
GCAGGCGTTGACCATGGTGC

Product: PdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MAQTSQPPMTVDLQPVQLVAADGTPTPEHRYSRELPAETLSWLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQV
GATACLRKTDWLFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIGTQSLHAVGAAMAAQRLGEDSV
TIAFLGDGATSVGDVHEALNFAAVFRTPCVFFVQNNQWAISLPVAKQTAAPSLAHKAIGYGMPGIRVDGNDVLACYAVTA
EAAARARAGRGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPRYRSYLQGQGLWSERLEERVIGRATRMRAE
LRDAVFDAPDLDVDEVFTAVYAEITPELQAQRRALRTELEKSD

Sequences:

>Translated_363_residues
MAQTSQPPMTVDLQPVQLVAADGTPTPEHRYSRELPAETLSWLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQV
GATACLRKTDWLFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIGTQSLHAVGAAMAAQRLGEDSV
TIAFLGDGATSVGDVHEALNFAAVFRTPCVFFVQNNQWAISLPVAKQTAAPSLAHKAIGYGMPGIRVDGNDVLACYAVTA
EAAARARAGRGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPRYRSYLQGQGLWSERLEERVIGRATRMRAE
LRDAVFDAPDLDVDEVFTAVYAEITPELQAQRRALRTELEKSD
>Mature_362_residues
AQTSQPPMTVDLQPVQLVAADGTPTPEHRYSRELPAETLSWLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQVG
ATACLRKTDWLFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIGTQSLHAVGAAMAAQRLGEDSVT
IAFLGDGATSVGDVHEALNFAAVFRTPCVFFVQNNQWAISLPVAKQTAAPSLAHKAIGYGMPGIRVDGNDVLACYAVTAE
AAARARAGRGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPRYRSYLQGQGLWSERLEERVIGRATRMRAEL
RDAVFDAPDLDVDEVFTAVYAEITPELQAQRRALRTELEKSD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=337, Percent_Identity=38.2789317507418, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI258645172, Length=337, Percent_Identity=38.2789317507418, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI291084742, Length=327, Percent_Identity=30.5810397553517, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI4505685, Length=327, Percent_Identity=30.5810397553517, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=30.9375, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI291084744, Length=334, Percent_Identity=29.940119760479, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI291084757, Length=310, Percent_Identity=29.6774193548387, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=368, Percent_Identity=34.2391304347826, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI86563357, Length=368, Percent_Identity=34.2391304347826, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17536047, Length=360, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564172, Length=360, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321026, Length=327, Percent_Identity=29.0519877675841, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355903, Length=354, Percent_Identity=32.4858757062147, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24639740, Length=350, Percent_Identity=29.1428571428571, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24639744, Length=350, Percent_Identity=29.1428571428571, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571106, Length=350, Percent_Identity=29.1428571428571, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24639746, Length=317, Percent_Identity=29.9684542586751, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39725; Mature: 39594

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTSQPPMTVDLQPVQLVAADGTPTPEHRYSRELPAETLSWLYEMMVLTRELDGEFVNL
CCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEE
KRQGQLALFASCRGQEAAQVGATACLRKTDWLFPQYRELGAFLVRGIPPGNVGAVWRGTW
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEECCC
HGGLGFTDKCCAPLSIPIGTQSLHAVGAAMAAQRLGEDSVTIAFLGDGATSVGDVHEALN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
FAAVFRTPCVFFVQNNQWAISLPVAKQTAAPSLAHKAIGYGMPGIRVDGNDVLACYAVTA
HHHHHHCCEEEEEECCCEEEECCCHHHHCCHHHHHHHHHCCCCCEEECCCCEEEEEEEHH
EAAARARAGRGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPRYRSYLQGQG
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCC
LWSERLEERVIGRATRMRAELRDAVFDAPDLDVDEVFTAVYAEITPELQAQRRALRTELE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
KSD
CCC
>Mature Secondary Structure 
AQTSQPPMTVDLQPVQLVAADGTPTPEHRYSRELPAETLSWLYEMMVLTRELDGEFVNL
CCCCCCCEEEECCCEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEE
KRQGQLALFASCRGQEAAQVGATACLRKTDWLFPQYRELGAFLVRGIPPGNVGAVWRGTW
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEECCC
HGGLGFTDKCCAPLSIPIGTQSLHAVGAAMAAQRLGEDSVTIAFLGDGATSVGDVHEALN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
FAAVFRTPCVFFVQNNQWAISLPVAKQTAAPSLAHKAIGYGMPGIRVDGNDVLACYAVTA
HHHHHHCCEEEEEECCCEEEECCCHHHHCCHHHHHHHHHCCCCCEEECCCCEEEEEEEHH
EAAARARAGRGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPRYRSYLQGQG
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCC
LWSERLEERVIGRATRMRAELRDAVFDAPDLDVDEVFTAVYAEITPELQAQRRALRTELE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
KSD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]