Click here to switch to the map view.

The map label for this gene is pdhB

Identifier: 41408406

GI number: 41408406

Start: 2588045

End: 2589100

Strand: Reverse

Name: pdhB

Synonym: MAP2308c

Alternate gene names: 41408406

Gene position: 2589100-2588045 (Counterclockwise)

Preceding gene: 41408407

Following gene: 41408405

Centisome position: 53.61

GC content: 70.08

Gene sequence:

>1056_bases
ATGACCCAGCTCGCTGATCGCCCGACCGGCCACGGCGAAACCCTCACCGCGGCAGTGCAGGATGTCGCGCTGCACGCGCA
GGCGTTGACCATGGTGCAGGCGCTCAACCGCGCCCTGCACGACGCGATGGCCGCCGACGAGCGGGTGCTGGTGTTCGGTG
AAGACGTCGCGGTCCAGGGCGGTGTCTTCCGGGTGACCGAAGGGCTGGCGGAGGCGTTCGGCGAGAGTCGTTGCTTCGAT
ACGCCGTTGGCGGAATCCGCGATCATCGGCATCGCGGTGGGGCTGGCGCTGCGCGGCTTCGTGCCGGTGCCGGAGATCCA
GTTCGACGGGTTCTCCTACCCGGCGTTCGACCAAGTGGTCAGCCATCTGGCGAAGTACCGCACCCGGACCCGCGGCGCGA
TCGACATGCCGGTGACGGTCCGGGTACCGTCGTTCGGCGGAATCGGTGCCGCCGAACATCATTCGGAATCCACCGAGTCG
TACTGGGCGCACACCGCCGGCCTGAAGGTGGTGGTGCCGTCCAACCCGGCCGACGCGTACTGGCTGCTGCGCCACGCCAT
CGCCTGCCCGGACCCGGTGATGTACCTGGAGCCCAAGCGTCGCTACCAAGGCCGCGGCCTGGTGGACGCCGGCCGGCCCG
AACCGCCGATCGGGCGGGCGATGGTGCGCCGGGCGGGGACCGACGTGACCGTCGTGACCTACGGCAGTCTGGTCGGCACG
GCGGTCGGAGCCGCCGAAGAGGCTCAGCGCCAACGCGGTTGGAGCCTGGAGGTCATCGACCTGCGGTCGTTGGTGCCGCT
GGACTTCGACACCATCGCGACATCCATCCACCGGACCGGTCGGTGCGTGGTGATGCACGAGGGGCCGCGGACCCTGGGTT
ACGGAGCCGAGCTGGCCGCCCGCATCCAGGAGGAGTTGTTCTACGAACTGGAGGCGCCGGTGTTGCGCGCGTGCGGATTC
GACACCCCCTACCCGCCGGCCCGGCTGGAGAAGTGGTGGCTGCCGGGCCCGGACCGGCTGCTGGACTGCGTCGAGCGCAC
GTTGGAGCTGCCGTGA

Upstream 100 bases:

>100_bases
CGTCGACGAGGTGTTCACCGCGGTGTACGCCGAAATCACGCCGGAGCTGCAGGCGCAGCGCCGTGCGCTGCGGACCGAAC
TCGAGAAAAGTGATTGAGAG

Downstream 100 bases:

>100_bases
GCGACGAGCGCGTCAAACCGTTTCTGGTCCCGGATCTCGGCGAGGGACTCGAAGAGGTGACCGTGACGCACTGGAACGTC
GCGGTGGGCGACGACGTCGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTQLADRPTGHGETLTAAVQDVALHAQALTMVQALNRALHDAMAADERVLVFGEDVAVQGGVFRVTEGLAEAFGESRCFD
TPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTES
YWAHTAGLKVVVPSNPADAYWLLRHAIACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVGT
AVGAAEEAQRQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMHEGPRTLGYGAELAARIQEELFYELEAPVLRACGF
DTPYPPARLEKWWLPGPDRLLDCVERTLELP

Sequences:

>Translated_351_residues
MTQLADRPTGHGETLTAAVQDVALHAQALTMVQALNRALHDAMAADERVLVFGEDVAVQGGVFRVTEGLAEAFGESRCFD
TPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTES
YWAHTAGLKVVVPSNPADAYWLLRHAIACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVGT
AVGAAEEAQRQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMHEGPRTLGYGAELAARIQEELFYELEAPVLRACGF
DTPYPPARLEKWWLPGPDRLLDCVERTLELP
>Mature_350_residues
TQLADRPTGHGETLTAAVQDVALHAQALTMVQALNRALHDAMAADERVLVFGEDVAVQGGVFRVTEGLAEAFGESRCFDT
PLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTESY
WAHTAGLKVVVPSNPADAYWLLRHAIACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVGTA
VGAAEEAQRQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMHEGPRTLGYGAELAARIQEELFYELEAPVLRACGFD
TPYPPARLEKWWLPGPDRLLDCVERTLELP

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=330, Percent_Identity=39.3939393939394, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI34101272, Length=330, Percent_Identity=39.3939393939394, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI156564403, Length=334, Percent_Identity=35.0299401197605, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI291084858, Length=334, Percent_Identity=33.8323353293413, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17506935, Length=339, Percent_Identity=38.9380530973451, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17538422, Length=331, Percent_Identity=36.5558912386707, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=329, Percent_Identity=34.9544072948328, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=40.9785932721713, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=40.9785932721713, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21358145, Length=334, Percent_Identity=40.4191616766467, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24650940, Length=334, Percent_Identity=40.4191616766467, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24650943, Length=95, Percent_Identity=44.2105263157895, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650945, Length=95, Percent_Identity=44.2105263157895, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38222; Mature: 38091

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLADRPTGHGETLTAAVQDVALHAQALTMVQALNRALHDAMAADERVLVFGEDVAVQG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECC
GVFRVTEGLAEAFGESRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
SHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTESYWAHTAGLKVVVPSNPADAY
HHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHCCEEEEECCCCCHHH
WLLRHAIACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVGT
HHHHHHHCCCCCEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHH
AVGAAEEAQRQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMHEGPRTLGYGAELAA
HHHHHHHHHHHCCCCEEEEEHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
RIQEELFYELEAPVLRACGFDTPYPPARLEKWWLPGPDRLLDCVERTLELP
HHHHHHHHHHCHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQLADRPTGHGETLTAAVQDVALHAQALTMVQALNRALHDAMAADERVLVFGEDVAVQG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECC
GVFRVTEGLAEAFGESRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
SHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTESYWAHTAGLKVVVPSNPADAY
HHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHCCEEEEECCCCCHHH
WLLRHAIACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVGT
HHHHHHHCCCCCEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHH
AVGAAEEAQRQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMHEGPRTLGYGAELAA
HHHHHHHHHHHCCCCEEEEEHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
RIQEELFYELEAPVLRACGFDTPYPPARLEKWWLPGPDRLLDCVERTLELP
HHHHHHHHHHCHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA