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The map label for this gene is ptpA

Identifier: 41408083

GI number: 41408083

Start: 2191193

End: 2191684

Strand: Direct

Name: ptpA

Synonym: MAP1985

Alternate gene names: 41408083

Gene position: 2191193-2191684 (Clockwise)

Preceding gene: 41408082

Following gene: 41408084

Centisome position: 45.37

GC content: 70.93

Gene sequence:

>492_bases
GTGTCTGAACCGCTGCACGTCACGTTCGTCTGCACCGGCAACATCTGCCGGTCGGTGATGGCCGAGAAGATGTTCGCCGA
CCAGCTGCGCCGCCGCGGCTTGGCCGATGCCGTGCGGGTGAGCAGCGCCGGCACCGGCAACTGGCATGTCGGCGAGTGCG
CCGACGAGCGGGCCGCCGGCGTGCTGCGCGCCCACGGCTACCCGACCGAGCACCGCGCCGCGCAGGTGGGCGCCGAGCAT
CTGTCCGCCGATCTGGTGGTGGCCCTGGACCGCAACCACGCCCGGATGCTGCGGCACCTGGGCGTCGACGAGGACCGCAT
CCGGATGCTGCGGTCGTTCGATCCGCGCACCGGCGCGCACACCCCCGACGTCGACGACCCCTACTACGGCGACAGCAAAG
ACTTCGAACGCGTCTACACCGTCATCGAGGCCGCGCTGCCCGGCCTGCACGACTGGGTCGACGAACGGCTGGCGCAGAAC
GGATCGTCGTGA

Upstream 100 bases:

>100_bases
ATCGACACCGTGGTGGTCGGCTGGGGCTACGGGCACGCCGACTCGCACCCCGACGGCGTCACCCGCGTCGCCACCATCGA
CGAGCTGCGGAGGGCGCTGG

Downstream 100 bases:

>100_bases
TGCCCCGGTGGCTGCGCGGCTTGTCGTTTCTGCTGCGGCCGGGCTGGGTCGTGCTGGCACTGGTGGTGGTCGCGTTCGCG
TACCTGTGCTTCACCGTGCT

Product: PtpA

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSEPLHVTFVCTGNICRSVMAEKMFADQLRRRGLADAVRVSSAGTGNWHVGECADERAAGVLRAHGYPTEHRAAQVGAEH
LSADLVVALDRNHARMLRHLGVDEDRIRMLRSFDPRTGAHTPDVDDPYYGDSKDFERVYTVIEAALPGLHDWVDERLAQN
GSS

Sequences:

>Translated_163_residues
MSEPLHVTFVCTGNICRSVMAEKMFADQLRRRGLADAVRVSSAGTGNWHVGECADERAAGVLRAHGYPTEHRAAQVGAEH
LSADLVVALDRNHARMLRHLGVDEDRIRMLRSFDPRTGAHTPDVDDPYYGDSKDFERVYTVIEAALPGLHDWVDERLAQN
GSS
>Mature_162_residues
SEPLHVTFVCTGNICRSVMAEKMFADQLRRRGLADAVRVSSAGTGNWHVGECADERAAGVLRAHGYPTEHRAAQVGAEHL
SADLVVALDRNHARMLRHLGVDEDRIRMLRSFDPRTGAHTPDVDDPYYGDSKDFERVYTVIEAALPGLHDWVDERLAQNG
SS

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=138, Percent_Identity=34.7826086956522, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI4757714, Length=138, Percent_Identity=34.0579710144928, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325330, Length=142, Percent_Identity=28.8732394366197, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI78706766, Length=156, Percent_Identity=32.0512820512821, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706768, Length=156, Percent_Identity=32.0512820512821, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706764, Length=124, Percent_Identity=34.6774193548387, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706770, Length=140, Percent_Identity=32.1428571428571, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI78706772, Length=140, Percent_Identity=32.1428571428571, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 18065; Mature: 17934

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLHVTFVCTGNICRSVMAEKMFADQLRRRGLADAVRVSSAGTGNWHVGECADERAAG
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
VLRAHGYPTEHRAAQVGAEHLSADLVVALDRNHARMLRHLGVDEDRIRMLRSFDPRTGAH
HHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCC
TPDVDDPYYGDSKDFERVYTVIEAALPGLHDWVDERLAQNGSS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEPLHVTFVCTGNICRSVMAEKMFADQLRRRGLADAVRVSSAGTGNWHVGECADERAAG
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
VLRAHGYPTEHRAAQVGAEHLSADLVVALDRNHARMLRHLGVDEDRIRMLRSFDPRTGAH
HHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHCCCCCCCC
TPDVDDPYYGDSKDFERVYTVIEAALPGLHDWVDERLAQNGSS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]