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The map label for this gene is cobC

Identifier: 41408081

GI number: 41408081

Start: 2189413

End: 2190483

Strand: Reverse

Name: cobC

Synonym: MAP1983c

Alternate gene names: 41408081

Gene position: 2190483-2189413 (Counterclockwise)

Preceding gene: 41408085

Following gene: 41408080

Centisome position: 45.35

GC content: 75.82

Gene sequence:

>1071_bases
GTGCTGCTCCGGGCCGCCGGGCCGGCCACTAATGTTTCACGGATGGCGAGTCTGAACCTGAGCCCGCCGGCGGCGCGCTA
CCACGGTGATCAGGCCGTCGCACCCGGGATGCTGGATTTCGCCGTCAACGTCCGGCACAGCCGGCCGCCGCAGTGGCTGC
TGGATCGGTTGGCGGCGCGGCTGCCCGACCTGGCCCGCTACCCGGGCGACGACGACGTGCACCGGGCGCAGGACGCCGCC
GCCGAACGGCACGGCCGCCGCCGCGACGAGGTGCTGCCGCTGGCCGGGGCGGCCGAGGCGTTCGCGCTGCTGAGCAACCT
GCGCCCGGCGCGGGCGGCGGTCATCGCGCCGTCGTTCACCGAGCCGGCCGCGGCGCTGAGCGCGGCCGGGGTGCCGGTGC
ACCACGTCGTGCTGGAGCCGCCGTTCGGTCTGCGCGGCGTGGCCGTCCCCGAGGAGGCCGACCTGGTGGTGGTGGGAAAT
CCCACCAATCCCACCGCGGTGCTGCACGGCCGCGAGCAGCTGCTGGCGCTGCGCCGGCCCGGACGGCTCCTGGTGGTCGA
CGAGGCGTTCGCCGACGCGATTCCCGGCGAGCCGCAATCGCTGGCCGGTGACGCGCTGCCCGACGTGCTGGTGCTGCGCA
GCCTGACCAAGACATGGGCGCTGGCCGGGCTGCGGGTGGGCTACGCGCTGGGCGCACCGGAGGTGCTGGCGCGGCTGACC
GCGCAGCGGGCGCACTGGCCGGTGGGCACGCTGCAGCTGACGGCGCTGGCGGCCTGCTGCGGCCGGCGGGCCGTCGCCGA
CGCGGCGGCCGGGGCGGAGCGGTTGAGCCGGCTGCGCGAGAAGATGGCGGCCGGGCTGGCGTCGGTGGGCGCCGACGTGC
TCGACGGGCGGGCGCCGTTTGTGTTGTTCCGGATGCCGGATGCGGTCCGGGTCCGAAAGCTGTTGCACGACAAGGGGATC
GCCGTCCGTCGCGGTGACACGTTCGTCGGCCTGGACGAGCGGTACCTGCGCGCCGCGGTGCGCCCGGAGTGGCCGCTGCT
GGTGCAGGCGATCGCGGAGGTGCAGCGGTGA

Upstream 100 bases:

>100_bases
TCACCAGCTGCGCCGCGGGGGCGGCGGGATCGGCTGACGTTGTGCCTGTCACCTCACCATTGTCCTCGATGGCCGCGGCG
GGCCGGGACGGTGTTGCTCG

Downstream 100 bases:

>100_bases
GCGTGAAACTCGCCGACGTCATCGCGGTGCTCGACCAGGCCTACCCGCCGTGGCTGGCCGAGCCCTGGGATTCGGTGGGG
CTGGTCTGCGGTGACCCCGA

Product: hypothetical protein

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLLRAAGPATNVSRMASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAARLPDLARYPGDDDVHRAQDAA
AERHGRRRDEVLPLAGAAEAFALLSNLRPARAAVIAPSFTEPAAALSAAGVPVHHVVLEPPFGLRGVAVPEEADLVVVGN
PTNPTAVLHGREQLLALRRPGRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGLRVGYALGAPEVLARLT
AQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVLDGRAPFVLFRMPDAVRVRKLLHDKGI
AVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEVQR

Sequences:

>Translated_356_residues
MLLRAAGPATNVSRMASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAARLPDLARYPGDDDVHRAQDAA
AERHGRRRDEVLPLAGAAEAFALLSNLRPARAAVIAPSFTEPAAALSAAGVPVHHVVLEPPFGLRGVAVPEEADLVVVGN
PTNPTAVLHGREQLLALRRPGRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGLRVGYALGAPEVLARLT
AQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVLDGRAPFVLFRMPDAVRVRKLLHDKGI
AVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEVQR
>Mature_356_residues
MLLRAAGPATNVSRMASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAARLPDLARYPGDDDVHRAQDAA
AERHGRRRDEVLPLAGAAEAFALLSNLRPARAAVIAPSFTEPAAALSAAGVPVHHVVLEPPFGLRGVAVPEEADLVVVGN
PTNPTAVLHGREQLLALRRPGRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGLRVGYALGAPEVLARLT
AQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVLDGRAPFVLFRMPDAVRVRKLLHDKGI
AVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEVQR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=287, Percent_Identity=28.9198606271777, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 37944; Mature: 37944

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRAAGPATNVSRMASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAAR
CCEECCCCCCCHHHHHCCCCCCCHHHHCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHH
LPDLARYPGDDDVHRAQDAAAERHGRRRDEVLPLAGAAEAFALLSNLRPARAAVIAPSFT
CCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHEEECCCCC
EPAAALSAAGVPVHHVVLEPPFGLRGVAVPEEADLVVVGNPTNPTAVLHGREQLLALRRP
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEECCHHHHHHHCCC
GRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGLRVGYALGAPEVLARLT
CCEEEEEHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVLDGRAPF
HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCE
VLFRMPDAVRVRKLLHDKGIAVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEVQR
EEEECCHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLLRAAGPATNVSRMASLNLSPPAARYHGDQAVAPGMLDFAVNVRHSRPPQWLLDRLAAR
CCEECCCCCCCHHHHHCCCCCCCHHHHCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHH
LPDLARYPGDDDVHRAQDAAAERHGRRRDEVLPLAGAAEAFALLSNLRPARAAVIAPSFT
CCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHEEECCCCC
EPAAALSAAGVPVHHVVLEPPFGLRGVAVPEEADLVVVGNPTNPTAVLHGREQLLALRRP
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEECCHHHHHHHCCC
GRLLVVDEAFADAIPGEPQSLAGDALPDVLVLRSLTKTWALAGLRVGYALGAPEVLARLT
CCEEEEEHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AQRAHWPVGTLQLTALAACCGRRAVADAAAGAERLSRLREKMAAGLASVGADVLDGRAPF
HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCE
VLFRMPDAVRVRKLLHDKGIAVRRGDTFVGLDERYLRAAVRPEWPLLVQAIAEVQR
EEEECCHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]