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The map label for this gene is panB

Identifier: 41408068

GI number: 41408068

Start: 2177649

End: 2178506

Strand: Direct

Name: panB

Synonym: MAP1970

Alternate gene names: 41408068

Gene position: 2177649-2178506 (Clockwise)

Preceding gene: 41408060

Following gene: 41408069

Centisome position: 45.09

GC content: 70.4

Gene sequence:

>858_bases
ATGTCTGAGCACAATGTTTACGGTGCCGCCCAGCCGGCCCAACCGGGCCAGCCCGCCCAGCCGCGCACCAGGATTCGCAC
CCACCATCTGCAAAAGATGAAGGCCGAGGGCCACAAGTGGGCCATGCTGACGGCGTACGACTATTCCACCGCCCGCATCT
TCGACGAGGCCGGCATCCCGGTGCTGCTGGTGGGCGACTCGGCGGCCAACGTCGTCTACGGCTACGACACCACCGTGCCG
GTGTCGATCGACGAGCTGATCCCGCTGGTCCGCGGCGTGGTGCGGGGGGCGCCGCACGCCCTGGTGGTCGCCGACCTGCC
GTTCGGCAGCTACGAGGCCGGGCCGGCCGCCGCTCTGGCCGCCGCCACCCGGTTCATGAAGGAGGGCGGCGCGCACGCGG
TGAAGCTGGAGGGCGGTGAACGGGTGGCCGAGCAGATCGCTCACCTGACCGCCGCGGGCATCCCGGTGATGGCGCACATC
GGCTTCACCCCGCAGAGCGTGAACAGCCTGGGCGGTTTCCGGGTGCAGGGCCGCGGCGACGCGGCCGAACAGACCATCGC
CGACGCGATCGCCGTCGCCGAGGCCGGAGCGTTCTCGGTGGTGATGGAGATGGTGCCGGCCGAGCTGGCCACCCAGATCA
CCGGCAAGCTCACCATCCCGACCATCGGGATCGGCGCCGGCCCCAACTGCGACGGCCAGGTTCTGGTTTGGCAGGACATG
GCCGGCATGAGCAGCGGCAAGTCCGCCCGCTTCGTCAAGCGCTTCGCCGACATCGGCGGCGAATTGCGCCGCGCCGCAAC
GCAGTATGCGCACGAGGTGGCCGCCGGGGTCTTCCCGGCCGACGAGCACTGCTTCTGA

Upstream 100 bases:

>100_bases
AATGGCAGAATGACACCCGTCAGACGAACCCGGGGACCCGCTCAGGATCTTTCAAAACTGAGGGCCACGAGGATCGACCC
GACCACCCACTAGGACAACG

Downstream 100 bases:

>100_bases
CGCGGTCGTTGGGGCCCTCGCCCCGCTGCGCTACTGTGACGGCGTAGCAAGGGTTTTAGCGCGCACCGCAACCGTCCCGG
TCACCGCCCGGCGGCTGGCG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVP
VSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHI
GFTPQSVNSLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDM
AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF

Sequences:

>Translated_285_residues
MSEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVP
VSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHI
GFTPQSVNSLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDM
AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF
>Mature_284_residues
SEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPV
SIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIG
FTPQSVNSLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDMA
GMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=47.8599221789883, Blast_Score=230, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6319653, Length=269, Percent_Identity=36.4312267657993, Blast_Score=173, Evalue=3e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29838; Mature: 29707

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCE
VLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALA
EEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
AATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGD
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCC
AAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECEEECCCCCCCCCCEEEEECC
AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHCCCCE
VLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALA
EEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
AATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGD
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCCC
AAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECEEECCCCCCCCCCEEEEECC
AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA