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The map label for this gene is lipB

Identifier: 41408056

GI number: 41408056

Start: 2162097

End: 2162798

Strand: Direct

Name: lipB

Synonym: MAP1958

Alternate gene names: 41408056

Gene position: 2162097-2162798 (Clockwise)

Preceding gene: 41408055

Following gene: 41408057

Centisome position: 44.77

GC content: 73.65

Gene sequence:

>702_bases
GTGATCGATTCCATCCGGTCCAGCCGCGCCCTGATCGATGTCCGCCGGCTCGGCACCGTCGACTACCGCGCGGCCTGGCA
GCAGCAACGCGACCTGGCCGACGCCCGGGTCGCCGGCGGCCCCGACACGTTGCTGTTGCTGCAACACCCGGCGGTGTACA
CCGCGGGCCGGCGCACCGAACCGCACGAGCGGCCGCTGGACGGCACGCCCGTGGTCGACACCGACCGGGGCGGCAAGATC
ACCTGGCACGGGCCCGGCCAGTTGGTCGGCTATCCGATCATCGGCCTGGCCGAACCGCTGGACGTGGTCGACTACGTGCG
ACGGCTGGAGGAGGCGCTGATCAAGGTGTGCGCCGACCTGGGCCTGGACACGGTCCGCGTGCCGGGCCGCTCCGGGGTGT
GGGTGCCGGGCGACGCCGGCCGGCCCGACCGCAAGGTGGCCGCCATCGGGGTGCGGGTGTCCCGCGCCACCACCCTGCAC
GGCTTCGCGCTGAACTGCGACTGCGAGCTGGGCGCCTTCAACGCCATCGTGCCGTGCGGCATCAGCGACGCCGGGGTGAC
GTCGCTGACGGCCGAACTGCGCCGCCCGGTCGCGGTCGACGACGTCGTGACGTCGGTCGCCGACGCCGTCTGCGACGCCC
TGGACGGGGTGCTGCCGGTGCGTGAGCACTCACCCGGCGCCCGCGTAGCATCGGCGATGTGA

Upstream 100 bases:

>100_bases
ACCATTGGCGAGGCGCTGGGCTATGCCACCGCCCGGCCCGCCCACGACTGACCCCGCCCGGATTGGGCCCGACCGGGCCG
GGCCGAGTACCGTCGCGAAC

Downstream 100 bases:

>100_bases
CTGTCGCACCCGAGGGACGCAAACTGCTGCGCCTGGAAGTGCGCAACGCCGAGACCCCGATCGAGCGCAAACCGCCGTGG
ATCCGGGTGCGGGCCCGGAT

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MIDSIRSSRALIDVRRLGTVDYRAAWQQQRDLADARVAGGPDTLLLLQHPAVYTAGRRTEPHERPLDGTPVVDTDRGGKI
TWHGPGQLVGYPIIGLAEPLDVVDYVRRLEEALIKVCADLGLDTVRVPGRSGVWVPGDAGRPDRKVAAIGVRVSRATTLH
GFALNCDCELGAFNAIVPCGISDAGVTSLTAELRRPVAVDDVVTSVADAVCDALDGVLPVREHSPGARVASAM

Sequences:

>Translated_233_residues
MIDSIRSSRALIDVRRLGTVDYRAAWQQQRDLADARVAGGPDTLLLLQHPAVYTAGRRTEPHERPLDGTPVVDTDRGGKI
TWHGPGQLVGYPIIGLAEPLDVVDYVRRLEEALIKVCADLGLDTVRVPGRSGVWVPGDAGRPDRKVAAIGVRVSRATTLH
GFALNCDCELGAFNAIVPCGISDAGVTSLTAELRRPVAVDDVVTSVADAVCDALDGVLPVREHSPGARVASAM
>Mature_233_residues
MIDSIRSSRALIDVRRLGTVDYRAAWQQQRDLADARVAGGPDTLLLLQHPAVYTAGRRTEPHERPLDGTPVVDTDRGGKI
TWHGPGQLVGYPIIGLAEPLDVVDYVRRLEEALIKVCADLGLDTVRVPGRSGVWVPGDAGRPDRKVAAIGVRVSRATTLH
GFALNCDCELGAFNAIVPCGISDAGVTSLTAELRRPVAVDDVVTSVADAVCDALDGVLPVREHSPGARVASAM

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=192, Percent_Identity=41.6666666666667, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI87081767, Length=181, Percent_Identity=31.4917127071823, Blast_Score=97, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323268, Length=222, Percent_Identity=29.2792792792793, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355483, Length=231, Percent_Identity=35.0649350649351, Blast_Score=130, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 24768; Mature: 24768

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSIRSSRALIDVRRLGTVDYRAAWQQQRDLADARVAGGPDTLLLLQHPAVYTAGRRTE
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCC
PHERPLDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVDYVRRLEEALIKVCADL
CCCCCCCCCCEEECCCCCEEEECCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHC
GLDTVRVPGRSGVWVPGDAGRPDRKVAAIGVRVSRATTLHGFALNCDCELGAFNAIVPCG
CCCEEEECCCCCEECCCCCCCCCCEEEEEEEEEECEEEEEEEEEECCCCCCCCCEEEECC
ISDAGVTSLTAELRRPVAVDDVVTSVADAVCDALDGVLPVREHSPGARVASAM
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MIDSIRSSRALIDVRRLGTVDYRAAWQQQRDLADARVAGGPDTLLLLQHPAVYTAGRRTE
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCC
PHERPLDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVDYVRRLEEALIKVCADL
CCCCCCCCCCEEECCCCCEEEECCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHC
GLDTVRVPGRSGVWVPGDAGRPDRKVAAIGVRVSRATTLHGFALNCDCELGAFNAIVPCG
CCCEEEECCCCCEECCCCCCCCCCEEEEEEEEEECEEEEEEEEEECCCCCCCCCEEEECC
ISDAGVTSLTAELRRPVAVDDVVTSVADAVCDALDGVLPVREHSPGARVASAM
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA