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The map label for this gene is cobI

Identifier: 41407910

GI number: 41407910

Start: 1988428

End: 1989918

Strand: Direct

Name: cobI

Synonym: MAP1812

Alternate gene names: 41407910

Gene position: 1988428-1989918 (Clockwise)

Preceding gene: 41407909

Following gene: 41407912

Centisome position: 41.17

GC content: 73.04

Gene sequence:

>1491_bases
ATGACGGCACCGGCCAACCCGCGAGGGACGTTGTGGGGCGTCGGGCTGGGGCCCGGTGACCCGGAGTTGGTCACCGTCAA
GGCCGCCCGGGTGATCGGCGAGGCCGACGTGGTCGCCTACCACAGCGCCCGGCACGGCCGCAGCATCGCCCGCGGCATCG
CCGAACCGTACCTGCGGCCCGGCCAGATCGAGGAGCACCTGGTGTACCCGGTCACCACCGAGGTGACCGACCATCCCGGC
GGCTATGCCGGCGCGATCGAGGACTTCTACGTCGAGGCCACCGCGCGCATCGCGGCGCACCTCGACGCGGGTCGCGACGT
GGCGCTGCTCGCCGAGGGCGACCCGCTGTTCTACAGCTCCTACATGCACCTCCACACCCGGCTGACGCAGCGGTTCGACG
CCGTCATCGTGCCGGGCGTGACCTCGGTGAGCGCCGCCTCGGCGGCCATCGCCACCCCGTTGGTGGCCGGCGACGAGGTG
CTGTCGGTGCTGCCGGGCACATTGCCGGTCTCCGAGCTGACCCGGCGCCTCGCCGACGCCGACGCCGCCGTCGTCCTCAA
GTTGGGACGCTCGTATCACGCTGTGCGGGAAGCTCTTTCACAGTCCGGTCAGCTCGACGACGCCGTCTATGTGGAGCGGG
CCAGCACGTCCGCGCAACGCATCGTGCCCGCCGCGGACGTGGACGCGGCCGGTGTCCCGTACTTCTCGCTGGCCATCCTG
CCGGGCGGGCAGCGCGCGCGGCGCGCGCCGGGCGCCGGCACCGTCGCGGTGGTGGGCCTGGGCCCCGGCGACGCGCAGTG
GATGACGCCGCAGAGCCGCCGCGAGTTGGCCGCGGCGACCGATCTCGTCGGCTACGGCCGTTACCTGGACCGGGTGCCGG
TTCGCGACGGTCAACGGCGCCACCCCAGCGACAACCGCGACGAACCCGAACGGGCGCGGCTGGCCTGCGCGCTGGCCGAG
CAGGGCCGGGCGGTGGCGGTGGTGTCGTCGGGCGATCCCGGCGTGTTCGCGATGGCGACCGCGGTGCTGGAGGAGGCCAA
GCAGTGGCCGGGCGTGCGGGTGCGGGTGATCCCGGCGATGACGGCCGCCCAGGCGGTCGCCAGCCGGGTCGGCGCGCCGT
TGGGGCACGACTACGCGGTGATCTCGCTGTCCGACCGGCTCAAGCCGTGGGAGGTGATCGCGGCGCGGCTGGAGGCCGCG
GCGGCCGCCGATCTCGTGCTGGCGATCTACAACCCGGCGTCCAAGACGCGGACCTGGCAGGTCGGCGCGATGCGCGACAT
TCTGCTGGCCCGTCGCGAACCCGGCACGCCGGTGGTCATCGGCCGCGACGTGTCCGGCCCCGACGAAGACGTCCGGGTGG
TGCGGCTGGCCGATCTGGATCCCGCCGAGATCGACATGCGCTGTCTGTTGATCGTCGGGTCCTCGCAAACCCAGTGGTAC
TCAGACGATTCCGCGGACCGGGTGTTCACGCCCCGGCGCTACGAGACGTAA

Upstream 100 bases:

>100_bases
TCGACAACCCGCGCGGCATGTCGTACCTGGTGGTGCGGGGCCGCCGCGGGGGTAGCGCGATGGCCGCCGCGGCCGTCAAC
GCGATCGCGAGCGACCGCGA

Downstream 100 bases:

>100_bases
CGCTCAGTCGCGGTCCCAGGTGCTGGGCATCATCGGCACGCCGGGGCCCTCGCTCAACCCGTCGCGGGTCAGCGTCGCCA
ATCCGGCGGGCCTCGCCGCT

Product: CobI

Products: NA

Alternate protein names: Precorrin-2 C(20)-methyltransferase; S-adenosyl-L-methionine--precorrin-2 methyltransferase; SP2MT; Precorrin-3B C17-methyltransferase; S-adenosyl-L-methionine--precorrin-3B methyltransferase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTAPANPRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHLVYPVTTEVTDHPG
GYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEV
LSVLPGTLPVSELTRRLADADAAVVLKLGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAIL
PGGQRARRAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRRHPSDNRDEPERARLACALAE
QGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVIAARLEAA
AAADLVLAIYNPASKTRTWQVGAMRDILLARREPGTPVVIGRDVSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWY
SDDSADRVFTPRRYET

Sequences:

>Translated_496_residues
MTAPANPRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHLVYPVTTEVTDHPG
GYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEV
LSVLPGTLPVSELTRRLADADAAVVLKLGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAIL
PGGQRARRAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRRHPSDNRDEPERARLACALAE
QGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVIAARLEAA
AAADLVLAIYNPASKTRTWQVGAMRDILLARREPGTPVVIGRDVSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWY
SDDSADRVFTPRRYET
>Mature_495_residues
TAPANPRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHLVYPVTTEVTDHPGG
YAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVL
SVLPGTLPVSELTRRLADADAAVVLKLGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAILP
GGQRARRAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRRHPSDNRDEPERARLACALAEQ
GRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAA
AADLVLAIYNPASKTRTWQVGAMRDILLARREPGTPVVIGRDVSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWYS
DDSADRVFTPRRYET

Specific function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A [H]

COG id: COG1010

COG function: function code H; Precorrin-3B methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR006364
- InterPro:   IPR006363
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.130; =2.1.1.131 [H]

Molecular weight: Translated: 52767; Mature: 52636

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPANPRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRP
CCCCCCCCCCEEECCCCCCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCC
GQIEEHLVYPVTTEVTDHPGGYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSS
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHH
YMHLHTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVSELTRRLADA
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCC
DAAVVLKLGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAIL
CCEEHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCEEEEEEE
PGGQRARRAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRR
CCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HPSDNRDEPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAM
CCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCH
TAAQAVASRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAAAADLVLAIYNPASKTRTWQ
HHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCEEEE
VGAMRDILLARREPGTPVVIGRDVSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWY
CHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEE
SDDSADRVFTPRRYET
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPANPRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRP
CCCCCCCCCEEECCCCCCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCC
GQIEEHLVYPVTTEVTDHPGGYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSS
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHH
YMHLHTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVSELTRRLADA
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCC
DAAVVLKLGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAIL
CCEEHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCEEEEEEE
PGGQRARRAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRR
CCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HPSDNRDEPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAM
CCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCH
TAAQAVASRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAAAADLVLAIYNPASKTRTWQ
HHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCEEEE
VGAMRDILLARREPGTPVVIGRDVSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWY
CHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEE
SDDSADRVFTPRRYET
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]