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The map label for this gene is lip2 [H]

Identifier: 41407833

GI number: 41407833

Start: 1896774

End: 1897700

Strand: Direct

Name: lip2 [H]

Synonym: MAP1735

Alternate gene names: 41407833

Gene position: 1896774-1897700 (Clockwise)

Preceding gene: 41407832

Following gene: 41407834

Centisome position: 39.27

GC content: 69.47

Gene sequence:

>927_bases
ATGGCTGACCGGCTCCCCGACGATGCCTTCACGGCGCCCCAGGTGGTGGATCCCGGTCTGCGCAAGGTGGCTCGATTCCT
GCCCCGCGGGTACGCCCTGCACCGCGGTCTCAAGCTGCAGCGCGCCATCATGAACCTGATGGGCAACGCGGGCCGCCTCC
GCACGGTGCCGGTGGTCGCGGTCAACGAGCACGTCACCGTCCGGCTGCACCGTCCACCCAACCTCGCCGAGCATGCGCCC
GCGCTGCTCTGGATCCACGGCGGCGGCACGGTCATGGGGCGCGCCGCCCAGGACGACAAGTACCTGCGCAAGCTTTCGCA
CCGCACCGGTGTCGCGATCGCGGCGGTGGAACACCGGTTGGCTCCCGAACACCCGTACCCCGCGCCGGTCGAGGACTGTT
ACGCGGCCCTGCTGTGGCTGGCGCGCCAGCCCTGGGTGGATCCGGAGCGGGTCGCCGTCGGTGGGGCAAGTGCCGGTGGA
CTTTTCGCGGCCACCCTGGCGCAGCGGGCGCACGACCGCAACGACGTCAAAATCGCCTTCCAGATGCTGGTGTATCCGAT
GCTCGACGATCGCACCGGCGCCCAACGCGACGGCCCCCGACGCCTCATGTGGACCGAATCCGACAACCAGCTGGCCTGGC
AGTGGTACCTCAACGGGGCCGATCCCGACGAGGCGGCACCGGCCCGCCGCAAGGACCTGTCGGGCTTGGCGCCGGCCTGG
ATCGGCGTCGGCACCCTGGACCTCTTTTATCCGGAGTGCCTGGAGTACGCGCGGCGTCTGCGCGAGGCCGGCGTTCCAGC
GCAGGAGGAGATCGTCCCCGGCGCGTTTCACGCCTTCGACCAGATCGTGGACAAGGCGCCGATCTCCGCCAAATTCTTCG
AAAGTCAGTGCGATTTTCTGCGCGGTGCTCTCGCCCCCAACGGGTGA

Upstream 100 bases:

>100_bases
GCGGACCCGCGATTCGCAAACCCCGTCGACACTATCCCGGTCCTGTATGGTCAGCGTGTCCACCGGCGCACGCAGACCGC
ACGGAAACCGAGGGCACTCG

Downstream 100 bases:

>100_bases
CAAGCCAGCCCGGCCCGGTACACCGCTGAGTTCCGTTGTCCGACAATCGCTCTCACGCGCCACGGGCACCGCCCGCGGCT
CTGCTCAGCCCCGCCGGACA

Product: hypothetical protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVAVNEHVTVRLHRPPNLAEHAP
ALLWIHGGGTVMGRAAQDDKYLRKLSHRTGVAIAAVEHRLAPEHPYPAPVEDCYAALLWLARQPWVDPERVAVGGASAGG
LFAATLAQRAHDRNDVKIAFQMLVYPMLDDRTGAQRDGPRRLMWTESDNQLAWQWYLNGADPDEAAPARRKDLSGLAPAW
IGVGTLDLFYPECLEYARRLREAGVPAQEEIVPGAFHAFDQIVDKAPISAKFFESQCDFLRGALAPNG

Sequences:

>Translated_308_residues
MADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVAVNEHVTVRLHRPPNLAEHAP
ALLWIHGGGTVMGRAAQDDKYLRKLSHRTGVAIAAVEHRLAPEHPYPAPVEDCYAALLWLARQPWVDPERVAVGGASAGG
LFAATLAQRAHDRNDVKIAFQMLVYPMLDDRTGAQRDGPRRLMWTESDNQLAWQWYLNGADPDEAAPARRKDLSGLAPAW
IGVGTLDLFYPECLEYARRLREAGVPAQEEIVPGAFHAFDQIVDKAPISAKFFESQCDFLRGALAPNG
>Mature_307_residues
ADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVAVNEHVTVRLHRPPNLAEHAPA
LLWIHGGGTVMGRAAQDDKYLRKLSHRTGVAIAAVEHRLAPEHPYPAPVEDCYAALLWLARQPWVDPERVAVGGASAGGL
FAATLAQRAHDRNDVKIAFQMLVYPMLDDRTGAQRDGPRRLMWTESDNQLAWQWYLNGADPDEAAPARRKDLSGLAPAWI
GVGTLDLFYPECLEYARRLREAGVPAQEEIVPGAFHAFDQIVDKAPISAKFFESQCDFLRGALAPNG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=182, Percent_Identity=31.8681318681319, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI157041239, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI206597554, Length=134, Percent_Identity=32.089552238806, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567059, Length=263, Percent_Identity=25.4752851711027, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=172, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71996133, Length=304, Percent_Identity=25.9868421052632, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001146, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33994; Mature: 33863

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVA
CCCCCCCCCCCCCHHCCHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHCCCCCEEEEEEEE
VNEHVTVRLHRPPNLAEHAPALLWIHGGGTVMGRAAQDDKYLRKLSHRTGVAIAAVEHRL
ECCEEEEEEECCCCHHHCCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCEEHHHHHHHC
APEHPYPAPVEDCYAALLWLARQPWVDPERVAVGGASAGGLFAATLAQRAHDRNDVKIAF
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCCCHHHHH
QMLVYPMLDDRTGAQRDGPRRLMWTESDNQLAWQWYLNGADPDEAAPARRKDLSGLAPAW
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCHHH
IGVGTLDLFYPECLEYARRLREAGVPAQEEIVPGAFHAFDQIVDKAPISAKFFESQCDFL
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RGALAPNG
HHHCCCCC
>Mature Secondary Structure 
ADRLPDDAFTAPQVVDPGLRKVARFLPRGYALHRGLKLQRAIMNLMGNAGRLRTVPVVA
CCCCCCCCCCCCHHCCHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHCCCCCEEEEEEEE
VNEHVTVRLHRPPNLAEHAPALLWIHGGGTVMGRAAQDDKYLRKLSHRTGVAIAAVEHRL
ECCEEEEEEECCCCHHHCCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCEEHHHHHHHC
APEHPYPAPVEDCYAALLWLARQPWVDPERVAVGGASAGGLFAATLAQRAHDRNDVKIAF
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCCCHHHHH
QMLVYPMLDDRTGAQRDGPRRLMWTESDNQLAWQWYLNGADPDEAAPARRKDLSGLAPAW
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCHHH
IGVGTLDLFYPECLEYARRLREAGVPAQEEIVPGAFHAFDQIVDKAPISAKFFESQCDFL
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RGALAPNG
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]