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The map label for this gene is gmk

Identifier: 41407221

GI number: 41407221

Start: 1176608

End: 1177279

Strand: Direct

Name: gmk

Synonym: MAP1123

Alternate gene names: 41407221

Gene position: 1176608-1177279 (Clockwise)

Preceding gene: 41407220

Following gene: 41407222

Centisome position: 24.36

GC content: 70.98

Gene sequence:

>672_bases
GTGACTGCCGACGGGGGACCGGACGTCCGGCATGGGACGCGTCCCGAACCATCAGGTGACGGACGTGTGGTCGTGCTGTC
CGGTCCCTCCGCGGTCGGCAAATCGACAGTGGTTCGGTGCCTGCGCGAGCGGGTCCCCAACCTGCATTTCTCCGTCTCGG
CCACGACGCGGGCACCGCGGCCGGGCGAGGTCGACGGCGTCGACTACCACTTCGTCAGCCCCGCCCGATTCCAGCAGCTC
ATCGACGAGGGCGCGCTGCTGGAGTGGGCCGAAATCCACTCCGGGCTGCACCGGTCGGGCACCCTGGCCGCGCCGGTGCG
GGCCGCCGTCGCGCGGGGCTGCCCGGTGCTGATCGAGGTCGACCTGGCCGGCGCCCGGGCGGTGAAGAAGGCGATGCCCG
AGGCGCTCACCGTGTTCCTGGCCCCGCCCAGCTGGGAGGACCTGGAGGCCAGGCTGATCGGCCGGGGCACCGAAACCCCG
GAGGTCATCGCCCGGCGCCTGCAGACCGCCCGCGTCGAAATGGCGGCCCAACACGACTTCGACCGGGTGGTGGTCAACAG
TCGATTGGAGTCTGCCTGCGCCGAATTGGTATCCTTGCTGGTGGGAACTGCGCCGGACCGGCACGATACGTCTGGCCGGA
CCGGGCGCCAGACCACCTCCCATCCCGATTGA

Upstream 100 bases:

>100_bases
AAGTTCGGCTCCTAACCCGCCCGCCGACGATGCAGGCCGCACGGCCTGAGGAGGCGGGCCATCGGACCCGAGCCGTGGGC
GCATCCGACCGGGAGCGCCC

Downstream 100 bases:

>100_bases
GCACCGAATCCTCAATATTTTTCAGTGGCTTTCCGGTAGCGACGAGCCGCTCCAATCCGCCAGGAGATTGACCTACGTGA
CTAACTCGCAGTCCGACGCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPRPGEVDGVDYHFVSPARFQQL
IDEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEVDLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETP
EVIARRLQTARVEMAAQHDFDRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD

Sequences:

>Translated_223_residues
MTADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPRPGEVDGVDYHFVSPARFQQL
IDEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEVDLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETP
EVIARRLQTARVEMAAQHDFDRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD
>Mature_222_residues
TADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPRPGEVDGVDYHFVSPARFQQLI
DEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEVDLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETPE
VIARRLQTARVEMAAQHDFDRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=40.9836065573771, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=40.9836065573771, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI226874831, Length=179, Percent_Identity=41.340782122905, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI38570142, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI14780902, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1790080, Length=197, Percent_Identity=35.0253807106599, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=37.5, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=37.5, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=42.1621621621622, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21356141, Length=184, Percent_Identity=34.7826086956522, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=28.804347826087, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=28.4153005464481, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_MYCPA (P60553)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960057.1
- ProteinModelPortal:   P60553
- SMR:   P60553
- EnsemblBacteria:   EBMYCT00000040461
- GeneID:   2721634
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1123
- NMPDR:   fig|262316.1.peg.1123
- GeneTree:   EBGT00050000017746
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23871; Mature: 23740

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
PGEVDGVDYHFVSPARFQQLIDEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEV
CCCCCCCCEEEECHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEE
DLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETPEVIARRLQTARVEMAAQHDF
ECCHHHHHHHHCHHHEEEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCH
DRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
PGEVDGVDYHFVSPARFQQLIDEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEV
CCCCCCCCEEEECHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEE
DLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETPEVIARRLQTARVEMAAQHDF
ECCHHHHHHHHCHHHEEEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCH
DRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA