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The map label for this gene is aroK

Identifier: 41407190

GI number: 41407190

Start: 1145827

End: 1146357

Strand: Direct

Name: aroK

Synonym: MAP1092

Alternate gene names: 41407190

Gene position: 1145827-1146357 (Clockwise)

Preceding gene: 41407189

Following gene: 41407191

Centisome position: 23.72

GC content: 74.95

Gene sequence:

>531_bases
ATGGCGCCCAAAGCGGTGCTGATCGGGCTGCCGGGCTCCGGCAAGTCCACCATCGGGCGGCGGCTGGCCAAGGCGCTCGG
GGTGGGTTTCCTGGACACCGATGCGGCCATCGAGCAGCGCACCGGCCGGCCCATCGCCGAGATCTTCGCCACCGACGGTG
AGCGGGAGTTCCGCCGCATCGAGGAGGAGGTGGTGCGCGCGGCGCTGACCGAGCACGACGGCGTGCTGTCGCTGGGCGGC
GGCGCGGTCACCAGCCCCGGGGTGCGCGAGGCGCTGGCCGGCCACACCGTCGTCTACCTGGAGATCAGCGCCACCGAGGG
GGTGCGGCGCACCGGCGGCAACACGGTGCGCCCGCTGCTGGCCGGGCCGGATCGCGCCGAGAAGTACCGCGCGCTGCTGG
CCGAGCGCAGCCCGCTGTACCGGCGGGCCGCCACCATCCGGGTCGACACCAACCGGCGCAACCCCGGCGCGGTGGTGCGC
TACATCGTGTCGCGGCTGCCCGCCACCGATGCCTGCCGGGCCGCCACATGA

Upstream 100 bases:

>100_bases
AGTTCGGCGGCGACTCGCTGGCCGAGACCCGCCGCAACATCGACGCCTACCGGCGGGCGGTCGCCGAGCGCGAGGCGCCG
GCCGCCCGGGGAACCGCGTG

Downstream 100 bases:

>100_bases
GAACCACCCGCGAACCGGTGACCGTGCAGGTGGCCGTCGACCCGCCCTACCCGGTGATCATCGGCACCGGGCTGCTGGGC
GAGCTGGACGAACTGCTCGG

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MAPKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRIEEEVVRAALTEHDGVLSLGG
GAVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLLAGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVR
YIVSRLPATDACRAAT

Sequences:

>Translated_176_residues
MAPKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRIEEEVVRAALTEHDGVLSLGG
GAVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLLAGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVR
YIVSRLPATDACRAAT
>Mature_175_residues
APKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRIEEEVVRAALTEHDGVLSLGGG
AVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLLAGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVRY
IVSRLPATDACRAAT

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=175, Percent_Identity=40.5714285714286, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1786587, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_MYCA1 (A0QI60)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_882598.1
- ProteinModelPortal:   A0QI60
- SMR:   A0QI60
- STRING:   A0QI60
- EnsemblBacteria:   EBMYCT00000013254
- GeneID:   4528730
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_3416
- TIGR:   MAV_3416
- eggNOG:   COG0703
- GeneTree:   EBGT00050000016251
- HOGENOM:   HBG335815
- OMA:   MSISAFF
- PhylomeDB:   A0QI60
- ProtClustDB:   PRK00131
- BioCyc:   MAVI243243:MAV_3416-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 18757; Mature: 18625

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 34-34 BINDING 58-58 BINDING 80-80 BINDING 117-117 BINDING 136-136 BINDING 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRI
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHH
EEEVVRAALTEHDGVLSLGGGAVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLL
HHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHCCCEEEEEEEECCCCHHHCCCCCCCCCC
AGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVRYIVSRLPATDACRAAT
CCCCHHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
APKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRI
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHH
EEEVVRAALTEHDGVLSLGGGAVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLL
HHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHCCCEEEEEEEECCCCHHHCCCCCCCCCC
AGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVRYIVSRLPATDACRAAT
CCCCHHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA