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The map label for this gene is acoA [H]

Identifier: 41406786

GI number: 41406786

Start: 708525

End: 709418

Strand: Direct

Name: acoA [H]

Synonym: MAP0688

Alternate gene names: 41406786

Gene position: 708525-709418 (Clockwise)

Preceding gene: 41406785

Following gene: 41406788

Centisome position: 14.67

GC content: 71.14

Gene sequence:

>894_bases
ATGACAGCACCCGAACACGACGACCGGCTGGAGCCCTACCGCCGGATGTGGGTCTTGCGGCTGCTCGACATGGCGCTGGA
CGAATCAGGCGTCGGCGCCGCGATCGACGACGACGCGCCGGTGGACTTCGGGCAGGAGGCGGTCGCCGTCGGGGCGGTCG
CCGCGCTTCGACCGGGAGACCTGGTCAACGCGACTACCCCGCGATTCCGGCACGCCCAGCAGATCGGCCTGGGCCTGCCG
CTGGGCCCGGCGATCGCGGAGTTGCTCGGAACCACGCGCGGAGGCGCCGGCGGATCGCGGAAAAGCGGTGCGGCTGACTG
GAAGCAGGCGCTGGCCAACGAAAGCGCGTTGGGGCAATCGACCCTGTTTGCGCTCGGCGACGCCAACGCGCAGCGGATGG
CCGGTGACGGCAGGGTCACGCTGTGTGCCATCGCGGGTAGTGACACGCACTCCGTCGAGTTCGCCACGGCCGCAAAGATC
GCCGCGTCGTGGCGGTTGCCGGTGGTGTTCGTCGTGCAGAATGTCCGCGGCGGCCCGGATGCCCGGCGGTGCGCCTACCG
GTCCGAGACGATGCCCATGGCGTTGGTCGACGACAGAGACGTTGTGGCCGTGGGTGATTCGGTGGGCCAAGCGGTACGGC
GCGCCAGCGCCGGCGGCGGGCCAAGCCTGGTCGAGGCGATCACCTACCGGACGAACCACCCCGTCGCCATCGACCCGCTG
GTCCTGGCGCGACGGCGGCTGATGGCCGACGGGATCGATCCCGACCGGCTCGTGGAGGTCGAACGCGGAGCCCGGCATCT
GGTGGCCGAGGCGATGGCGTGCGCGAAAGCGCTGGTGCGAGCGCGGCGGTTCGATGCGGTGAGCGCACCCGACCGCTGGT
CGGCTGCTAGCTGA

Upstream 100 bases:

>100_bases
CATTCATCACGTTTGCGGACCGATCGGCGGAGGCGCGCCGCGGGCTATCCCCCTACCTTGAGGACCAAGCAAATCGCTTG
CGACTCAGGAGGTCCGGCAC

Downstream 100 bases:

>100_bases
GCAGACCTTGGCGCATTGCCTCGGCGACGGCGGCCGCGCGGTCGCTGACCCCCAGCTTCTCGTAGAGGCGTTGCACGTGG
GTCTTGACCGTCGACGGCGC

Product: hypothetical protein

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTAPEHDDRLEPYRRMWVLRLLDMALDESGVGAAIDDDAPVDFGQEAVAVGAVAALRPGDLVNATTPRFRHAQQIGLGLP
LGPAIAELLGTTRGGAGGSRKSGAADWKQALANESALGQSTLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFATAAKI
AASWRLPVVFVVQNVRGGPDARRCAYRSETMPMALVDDRDVVAVGDSVGQAVRRASAGGGPSLVEAITYRTNHPVAIDPL
VLARRRLMADGIDPDRLVEVERGARHLVAEAMACAKALVRARRFDAVSAPDRWSAAS

Sequences:

>Translated_297_residues
MTAPEHDDRLEPYRRMWVLRLLDMALDESGVGAAIDDDAPVDFGQEAVAVGAVAALRPGDLVNATTPRFRHAQQIGLGLP
LGPAIAELLGTTRGGAGGSRKSGAADWKQALANESALGQSTLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFATAAKI
AASWRLPVVFVVQNVRGGPDARRCAYRSETMPMALVDDRDVVAVGDSVGQAVRRASAGGGPSLVEAITYRTNHPVAIDPL
VLARRRLMADGIDPDRLVEVERGARHLVAEAMACAKALVRARRFDAVSAPDRWSAAS
>Mature_296_residues
TAPEHDDRLEPYRRMWVLRLLDMALDESGVGAAIDDDAPVDFGQEAVAVGAVAALRPGDLVNATTPRFRHAQQIGLGLPL
GPAIAELLGTTRGGAGGSRKSGAADWKQALANESALGQSTLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFATAAKIA
ASWRLPVVFVVQNVRGGPDARRCAYRSETMPMALVDDRDVVAVGDSVGQAVRRASAGGGPSLVEAITYRTNHPVAIDPLV
LARRRLMADGIDPDRLVEVERGARHLVAEAMACAKALVRARRFDAVSAPDRWSAAS

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=248, Percent_Identity=28.2258064516129, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI291084742, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4505685, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536047, Length=248, Percent_Identity=27.8225806451613, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32564172, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 31250; Mature: 31119

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPEHDDRLEPYRRMWVLRLLDMALDESGVGAAIDDDAPVDFGQEAVAVGAVAALRPGD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LVNATTPRFRHAQQIGLGLPLGPAIAELLGTTRGGAGGSRKSGAADWKQALANESALGQS
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHCCCH
TLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFATAAKIAASWRLPVVFVVQNVRGGPD
HEEEECCCCHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCCCCEEEEEECCCCCCH
ARRCAYRSETMPMALVDDRDVVAVGDSVGQAVRRASAGGGPSLVEAITYRTNHPVAIDPL
HHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECHH
VLARRRLMADGIDPDRLVEVERGARHLVAEAMACAKALVRARRFDAVSAPDRWSAAS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPEHDDRLEPYRRMWVLRLLDMALDESGVGAAIDDDAPVDFGQEAVAVGAVAALRPGD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LVNATTPRFRHAQQIGLGLPLGPAIAELLGTTRGGAGGSRKSGAADWKQALANESALGQS
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHCCCH
TLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFATAAKIAASWRLPVVFVVQNVRGGPD
HEEEECCCCHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCCCCEEEEEECCCCCCH
ARRCAYRSETMPMALVDDRDVVAVGDSVGQAVRRASAGGGPSLVEAITYRTNHPVAIDPL
HHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECHH
VLARRRLMADGIDPDRLVEVERGARHLVAEAMACAKALVRARRFDAVSAPDRWSAAS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]