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The map label for this gene is mcmA2

Identifier: 41406772

GI number: 41406772

Start: 695934

End: 696374

Strand: Direct

Name: mcmA2

Synonym: MAP0674

Alternate gene names: 41406772

Gene position: 695934-696374 (Clockwise)

Preceding gene: 41406771

Following gene: 41406773

Centisome position: 14.41

GC content: 70.07

Gene sequence:

>441_bases
GTGGCCGTCCGGATTCTGGTTGCCAAACCCGGGTTGGACGGACACGACCGGGGCGCCAAGATCGTGGCCCGCACCTTGCG
GGACGCCGGATTCGAGGTCATCTACACCGGCATCCGGCAGCGTATCGAGGACATCGCCTCGATCGCCGTCCAGGAGGACG
TGGCGGTGGTCGGCCTGAGCATCCTGTCCGGCACCCACCTGGCGCTCACCGCGCGCACCGTCGAGGCGCTGCGCGCCTGC
GACGCCGCTGACATCGCCGTCGTCGTCGGCGGAACCATCCCGCACGCCGACGTCCCCAAGCTGCTCGCGGCCGGTGCCGC
GGCCGTATTCCCCACCGGCACGCCGCTGGACAAACTGGTGCGTGAGATCCGCGCACTGACCGGCACCGGGGAGCCGGACG
ACAAGGAAGCGATCACGGAGGAACAGTGCGCGTCGGAGTGA

Upstream 100 bases:

>100_bases
ACAAGCTCATCGACTGCGCCAACGCGTACTGCACGGTCGGGGAGATGGTCTCCGCGCTCAAGGCGGTGTGGGGCGAATTC
CAGCAACCGGTGGTGTTCTA

Downstream 100 bases:

>100_bases
TGATCGGCGCCGAGCGCGGCGACATGGCCCGCAAGGTGAACAAGCTGGTCTCCGACATCGAATGGGCCGAGTCGGCGGGA
CTGGACACGGCGTGGATGCC

Product: McmA2

Products: succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MAVRILVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIASIAVQEDVAVVGLSILSGTHLALTARTVEALRAC
DAADIAVVVGGTIPHADVPKLLAAGAAAVFPTGTPLDKLVREIRALTGTGEPDDKEAITEEQCASE

Sequences:

>Translated_146_residues
MAVRILVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIASIAVQEDVAVVGLSILSGTHLALTARTVEALRAC
DAADIAVVVGGTIPHADVPKLLAAGAAAVFPTGTPLDKLVREIRALTGTGEPDDKEAITEEQCASE
>Mature_145_residues
AVRILVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIASIAVQEDVAVVGLSILSGTHLALTARTVEALRACD
AADIAVVVGGTIPHADVPKLLAAGAAAVFPTGTPLDKLVREIRALTGTGEPDDKEAITEEQCASE

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=115, Percent_Identity=40.8695652173913, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1789284, Length=123, Percent_Identity=45.5284552845528, Blast_Score=98, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144500, Length=120, Percent_Identity=43.3333333333333, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: NA

Molecular weight: Translated: 15176; Mature: 15044

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRILVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIASIAVQEDVAVVGLS
CEEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGTHLALTARTVEALRACDAADIAVVVGGTIPHADVPKLLAAGAAAVFPTGTPLDKLV
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHCCCCCCCHHHHH
REIRALTGTGEPDDKEAITEEQCASE
HHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AVRILVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIASIAVQEDVAVVGLS
EEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGTHLALTARTVEALRACDAADIAVVVGGTIPHADVPKLLAAGAAAVFPTGTPLDKLV
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHCCCCCCCHHHHH
REIRALTGTGEPDDKEAITEEQCASE
HHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Co [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-methylmalonyl-CoA [C]

Specific reaction: L-methylmalonyl-CoA = succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]