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The map label for this gene is purM

Identifier: 41406737

GI number: 41406737

Start: 662437

End: 663531

Strand: Direct

Name: purM

Synonym: MAP0639

Alternate gene names: 41406737

Gene position: 662437-663531 (Clockwise)

Preceding gene: 41406736

Following gene: 41406740

Centisome position: 13.72

GC content: 69.59

Gene sequence:

>1095_bases
ATGACGGATCCCGGAAAAAGCCCCGGACGCCACTCGGGCAGTCAGGGCATCACCTACGCGTCGGCCGGGGTGGACATTGA
AGCCGGCGATCGCGCTGTCGAATTGTTCAAGCCGCTGGCGACCAAGGCCACGCGGCCCGAGGTGCGCGGCGGCCTGGGCG
GATTCGCCGGCTTGTTCGCGCTACGCGGCGAATACCGCGAGCCGCTGCTGGCGGCCTCCACCGACGGCGTCGGGACCAAG
CTGGCGGTCGCCCAGGCGATGGACAAGCACGACACCGTCGGGCTGGACCTGGTGGCGATGGTGGTCGACGACCTGGTGGT
GTGCGGCGCCGAGCCGCTGTTCTTGCAGGACTACATCGCGGTGGGCCGCACGGTGCCGGAACGGTTGAGCGCCATCGTCA
GTGGCATCGCCGAGGGCTGCGTGCGGGCCGGCTGCGCGCTGCTGGGCGGGGAGACGGCCGAACACCCGGGCCTGATGGAA
CCCGACCACTACGACATCTCGGCCACCGGCGTCGGCGTGGTCGAGGCCGACGACGTGCTGGGGCCGGATCGGGTCAAACC
CGGCGACGTCATCATCGCGATGGGCTCGTCGGGTCTGCACTCCAACGGATACTCGTTGGCCCGCACGGTGTTGCTCGAGA
TCGACCGGATGAACCTGGAAGGCTATGTCGAAGAGTTCGGCCGCACGCTGGGCGAAGAGCTGCTCGAACCCACCCGCATT
TACGCCAAGGACTGCCTGGCGCTGGCCGCCGAAACCCACGTGCGCACGTTCTGCCACGTCACCGGTGGGGGACTGGCCGG
CAACCTGGCGCGCGTCATCCCGCACGGGCTGGTCGCCGAGTTGGACCGCGGCACCTGGACCCCCGCGCCGGTGTTCGCCA
TGATCGCCCAGCGCGGCCGGGTGACCCGCGAGGAGATGGAGAAGACGTTCAACATGGGTGTCGGCATGATCGCCGTCGTC
GCCCCCGAGGACACCGACCGGGCCCTGGCCATCCTGACCGCCCGGCACCTGGACTGCTGGGTGCTGGGCACCGTGGGCAA
AGGCGGCAAGGCGGGGCCGCGGGCCAAACTCGTGGGCCAACACCCGAGATTTTGA

Upstream 100 bases:

>100_bases
CGACGACCTGGCGGCCGACGAAGTGCCCGTCGTCCACTGAGCGGCTCGTTCGCCGACGTTTGATACCGGCGGTCAGCGCC
GACCGGTAGCCTTTATCGCG

Downstream 100 bases:

>100_bases
ACGAGATTTTGAAATAGCCGCGCCGCGGTAGAACCAACGCGGCGCCGGTGCAGTACGCATCGGCGCCGGATTGTCGCTGT
TAGCCTCGCCAGCCGTCCTG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTDPGKSPGRHSGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFALRGEYREPLLAASTDGVGTK
LAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLME
PDHYDISATGVGVVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLARTVLLEIDRMNLEGYVEEFGRTLGEELLEPTRI
YAKDCLALAAETHVRTFCHVTGGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFNMGVGMIAVV
APEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQHPRF

Sequences:

>Translated_364_residues
MTDPGKSPGRHSGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFALRGEYREPLLAASTDGVGTK
LAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLME
PDHYDISATGVGVVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLARTVLLEIDRMNLEGYVEEFGRTLGEELLEPTRI
YAKDCLALAAETHVRTFCHVTGGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFNMGVGMIAVV
APEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQHPRF
>Mature_363_residues
TDPGKSPGRHSGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFALRGEYREPLLAASTDGVGTKL
AVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEP
DHYDISATGVGVVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLARTVLLEIDRMNLEGYVEEFGRTLGEELLEPTRIY
AKDCLALAAETHVRTFCHVTGGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFNMGVGMIAVVA
PEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQHPRF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=5e-79,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=47.7203647416413, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17567511, Length=358, Percent_Identity=33.5195530726257, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321203, Length=348, Percent_Identity=41.9540229885057, Blast_Score=260, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24582400, Length=268, Percent_Identity=38.8059701492537, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38258; Mature: 38127

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPGKSPGRHSGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFA
CCCCCCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHH
LRGEYREPLLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIA
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEPDHYDISATGVGVVEADDVL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCC
GPDRVKPGDVIIAMGSSGLHSNGYSLARTVLLEIDRMNLEGYVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETHVRTFCHVTGGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCC
VTREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQ
CCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
HPRF
CCCC
>Mature Secondary Structure 
TDPGKSPGRHSGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFA
CCCCCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHH
LRGEYREPLLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIA
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEPDHYDISATGVGVVEADDVL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCC
GPDRVKPGDVIIAMGSSGLHSNGYSLARTVLLEIDRMNLEGYVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETHVRTFCHVTGGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCC
VTREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQ
CCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
HPRF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA