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The map label for this gene is hemH

Identifier: 41406712

GI number: 41406712

Start: 639177

End: 640067

Strand: Direct

Name: hemH

Synonym: MAP0614

Alternate gene names: 41406712

Gene position: 639177-640067 (Clockwise)

Preceding gene: 41406710

Following gene: 41406713

Centisome position: 13.23

GC content: 66.55

Gene sequence:

>891_bases
ATGCCTGCACTGTCGGACTACCAGCATCTGGCCAGCGGCAAGGTCCGTGAGCTGTATCGCGTCGACGACGAGCACCTGCT
GTTGGTCGCCACCGACCGGATCTCGGCGTACGACTTCGTGCTGGACAGCACCATCCCGGACAAGGGCCGCATCCTGACGG
CGATGAGCGTCTTTTTCTTCGGCCTCGTCGATGCCCCCAACCACCTGGCCGGACCGCCCGACGACCCGCGCATTCCCGAC
GAGGTGTTGGGCCGCGCGCTGGTGGTGCGCCAGCTCGAGATGCTCCCGGTGGAATGCGTGGCGCGCGGCTACCTGACAGG
CTCGGGGCTACTGGACTACCAGGCGACCGGCAAGGTCTGCGGCATCGCGTTGCCGCCCGGACTGGTCGAGGCGAGCAAGT
TCGCCGAGCCGCTGTTCACCCCGGCGACCAAGGCCGCCCTGGGCGACCACGACGAGAACATCTCTTTTGCCCGGGTGATC
GAGATGGTCGGCGGGGTGCGGGCCAACCAGCTGCGCGACCGCACGTTGCAGATCTACGTCCAGGCCGCCGACCACGCGCT
ACGGAAGGGAATCATCATCGCGGACACCAAGTTCGAGTTCGGCACCGACCCGGATGGCAATCTTCTGCTGGCCGACGAGA
TCTTCACCCCGGACTCCTCGCGGTACTGGCCGGCCGACGAATACCGGGTCGGCGTGCCGCAGACCAGCTTCGACAAACAG
TTCGTCCGCAACTGGCTCACCAGCCCCGAATCCGGCTGGGACCGGCACGGCACCGAACCGCCCCCACCGCTGCCCGACCA
CATCATCGAGGCCACCCGCAACCGCTATATCGAAGCCTACGAACGCATTTCCGGGCTGCGTTTCGACGACTGGATCGGTC
CGCGCGCATGA

Upstream 100 bases:

>100_bases
GGCCAGCCGCCCGGGCCTGGTGGAGTAGGGCAGAAACCGCGGTGTCATAGCCTCGATCCCAGCACACGGCCGGCGTCCCG
GTGCCCGATAGGCTGACCGG

Downstream 100 bases:

>100_bases
CCGAGACCCACCTGGCCACCTCCGTGCCGCCCGTCGCCAAGCGGGTGGACACCCGCCGCGAGCATCACGGCGACGTCTTC
GTTGACCCCTACGAGTGGTT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPALSDYQHLASGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKGRILTAMSVFFFGLVDAPNHLAGPPDDPRIPD
EVLGRALVVRQLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASKFAEPLFTPATKAALGDHDENISFARVI
EMVGGVRANQLRDRTLQIYVQAADHALRKGIIIADTKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQ
FVRNWLTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPRA

Sequences:

>Translated_296_residues
MPALSDYQHLASGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKGRILTAMSVFFFGLVDAPNHLAGPPDDPRIPD
EVLGRALVVRQLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASKFAEPLFTPATKAALGDHDENISFARVI
EMVGGVRANQLRDRTLQIYVQAADHALRKGIIIADTKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQ
FVRNWLTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPRA
>Mature_295_residues
PALSDYQHLASGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKGRILTAMSVFFFGLVDAPNHLAGPPDDPRIPDE
VLGRALVVRQLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASKFAEPLFTPATKAALGDHDENISFARVIE
MVGGVRANQLRDRTLQIYVQAADHALRKGIIIADTKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQF
VRNWLTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPRA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=295, Percent_Identity=42.7118644067797, Blast_Score=246, Evalue=4e-66,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 32918; Mature: 32786

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALSDYQHLASGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKGRILTAMSVFFF
CCCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHEECCCCCCCCHHHHHHHHHHH
GLVDAPNHLAGPPDDPRIPDEVLGRALVVRQLEMLPVECVARGYLTGSGLLDYQATGKVC
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCEE
GIALPPGLVEASKFAEPLFTPATKAALGDHDENISFARVIEMVGGVRANQLRDRTLQIYV
EEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCEEEEEE
QAADHALRKGIIIADTKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQ
HHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECEECCCCCCCCCCCCCEECCCCCHHHHH
FVRNWLTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPRA
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure 
PALSDYQHLASGKVRELYRVDDEHLLLVATDRISAYDFVLDSTIPDKGRILTAMSVFFF
CCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHEECCCCCCCCHHHHHHHHHHH
GLVDAPNHLAGPPDDPRIPDEVLGRALVVRQLEMLPVECVARGYLTGSGLLDYQATGKVC
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCCCEE
GIALPPGLVEASKFAEPLFTPATKAALGDHDENISFARVIEMVGGVRANQLRDRTLQIYV
EEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCEEEEEE
QAADHALRKGIIIADTKFEFGTDPDGNLLLADEIFTPDSSRYWPADEYRVGVPQTSFDKQ
HHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECEECCCCCCCCCCCCCEECCCCCHHHHH
FVRNWLTSPESGWDRHGTEPPPPLPDHIIEATRNRYIEAYERISGLRFDDWIGPRA
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA