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The map label for this gene is purD

Identifier: 41406704

GI number: 41406704

Start: 630388

End: 631656

Strand: Direct

Name: purD

Synonym: MAP0606

Alternate gene names: 41406704

Gene position: 630388-631656 (Clockwise)

Preceding gene: 41406703

Following gene: 41406707

Centisome position: 13.05

GC content: 72.66

Gene sequence:

>1269_bases
GTGCGCGTCCTGGTGATCGGCTCCGGTGCCCGTGAGCATGCGCTGCTGCTGGCGCTGCGCAAAGACCCGCAAGTCACCGG
GCTGGCCATCGCCCCCGGCAACGCCGGCACCGCCCGGCTGGCCGAGCAGCACGACGTCGACATCACCTCGGCGCCCGACG
TCGTGGCTCTGGCCCGCGCGGTGCGCGCCGACCTGGTGGTCATCGGCCCCGAGGTGCCGCTGGTCCTCGGAGTCGCCGAC
GCGCTGCGGGCGGCCGGCATCGTGTGCTTCGGACCGGGCAAGGACGCCGCCCGCATCGAAGGCTCCAAGGCGTTCGCCAA
AGAGGTGATGGCCGCGGCCGGGGTCCGCACCGCGGCCAGTGAAATCGTCGATACCCCCGCGCATTTGGACGCCGCGCTGG
ACCGGTTCGGCCCGCCGGCGGGCGAGGCGGCCTGGGTGGTGAAGGACGACCGGCTGGCCGCGGGCAAGGGCGTGGTGGTG
ACAGCCGACCGCGAGGTGGCGCGCGCCCACGCCGCCGCGCTGCTGGAGGCCGGCCACCCGGTGCTGCTGGAGTCGTTTCT
GGACGGCCCGGAGGTGTCGCTGTTCTGCGTCGTCGACGGCGAGACCGTGGTGCCGCTGCTGCCGGCGCAGGATTTCAAGC
GGGTCGGCGACGCCGACAGCGGACCCAACACCGGCGGGATGGGCGCCTACGCCCCCGTGCCGTGGCTGCCCGATCGGGTG
TATCGCGACATCGTGCACCGCATCGTCGAACCCGTTGCGGCCGAGATGGTTGCGCGTGGCTGCCCGTTCAGCGGATTGCT
GTACGCCGGGCTGGCGATCACCTCCAACGGACCGGCCGTGGTCGAATTCAATTGCCGCTTCGGCGATCCCGAGACCCAGG
CGGTGCTGGCGCTGCTGGAGTCGCCGCTCGGGCAGCTGCTGTACGCGGCGGGCAGCGGCACCCTGGCGGACTTCGGTGAA
CTGCGCTGGCACGACGGTGCGGCGGTGACGGTGGTGCTGGCGGCGGCGAACTATCCCGGACGGCCCCGGGTGGGCGACGT
CATCACCGGCTCGGAAGCCGAGGGCGTGCTGCACGCCGGAACCGCGCGACGCGAGGACGGCGAGATCGTCTCCTCAGGGG
GCCGGGTGCTGTCGGTGGTGGGGACGGGCCCCGACCTGGCGGCCGCGCGGGCCAAGGCATACCAGATCCTCGGCTCGATT
CGGTTGCCGGGCAGCCATTTTCGCACCGACATCGCACAGTCGGCGGCCGACGGCAAGATCCGGGTCTAA

Upstream 100 bases:

>100_bases
GCCAAGGGCGCCGGCGAGGACAAGAAGGCCAACGTGGACGCCGCATTGAAGATGCACTCGGGCGGTGAGCGGGGCTGATC
GCCCGCTAGAGTGGCGTGTC

Downstream 100 bases:

>100_bases
AACGCGGCGGCCTGGCCGTCGCGGCGCGGGTCGCTGGCCGCGACGTAGCCGGTATCCATCCGCCAGATCGCCTGGCAGCT
GCCGAACTGGTTGTAGTCGT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQHDVDITSAPDVVALARAVRADLVVIGPEVPLVLGVAD
ALRAAGIVCFGPGKDAARIEGSKAFAKEVMAAAGVRTAASEIVDTPAHLDAALDRFGPPAGEAAWVVKDDRLAAGKGVVV
TADREVARAHAAALLEAGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRV
YRDIVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQAVLALLESPLGQLLYAAGSGTLADFGE
LRWHDGAAVTVVLAAANYPGRPRVGDVITGSEAEGVLHAGTARREDGEIVSSGGRVLSVVGTGPDLAAARAKAYQILGSI
RLPGSHFRTDIAQSAADGKIRV

Sequences:

>Translated_422_residues
MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQHDVDITSAPDVVALARAVRADLVVIGPEVPLVLGVAD
ALRAAGIVCFGPGKDAARIEGSKAFAKEVMAAAGVRTAASEIVDTPAHLDAALDRFGPPAGEAAWVVKDDRLAAGKGVVV
TADREVARAHAAALLEAGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRV
YRDIVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQAVLALLESPLGQLLYAAGSGTLADFGE
LRWHDGAAVTVVLAAANYPGRPRVGDVITGSEAEGVLHAGTARREDGEIVSSGGRVLSVVGTGPDLAAARAKAYQILGSI
RLPGSHFRTDIAQSAADGKIRV
>Mature_422_residues
MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQHDVDITSAPDVVALARAVRADLVVIGPEVPLVLGVAD
ALRAAGIVCFGPGKDAARIEGSKAFAKEVMAAAGVRTAASEIVDTPAHLDAALDRFGPPAGEAAWVVKDDRLAAGKGVVV
TADREVARAHAAALLEAGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRV
YRDIVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQAVLALLESPLGQLLYAAGSGTLADFGE
LRWHDGAAVTVVLAAANYPGRPRVGDVITGSEAEGVLHAGTARREDGEIVSSGGRVLSVVGTGPDLAAARAKAYQILGSI
RLPGSHFRTDIAQSAADGKIRV

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=424, Percent_Identity=41.2735849056604, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI4503915, Length=424, Percent_Identity=41.2735849056604, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI209869995, Length=424, Percent_Identity=41.2735849056604, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI209869993, Length=424, Percent_Identity=41.2735849056604, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1790438, Length=431, Percent_Identity=43.6194895591647, Blast_Score=313, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=427, Percent_Identity=36.768149882904, Blast_Score=234, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=446, Percent_Identity=37.4439461883408, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI62471619, Length=433, Percent_Identity=41.8013856812933, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24582400, Length=433, Percent_Identity=41.8013856812933, Blast_Score=268, Evalue=6e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 43377; Mature: 43377

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQHDVDITSAPDVVALARA
CEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
VRADLVVIGPEVPLVLGVADALRAAGIVCFGPGKDAARIEGSKAFAKEVMAAAGVRTAAS
HHCCEEEECCCCCEEEEHHHHHHHCCEEEECCCCCCCEECCHHHHHHHHHHHHCHHHHHH
EIVDTPAHLDAALDRFGPPAGEAAWVVKDDRLAAGKGVVVTADREVARAHAAALLEAGHP
HHHCCHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCEEEECCHHHHHHHHHHHHHCCCH
VLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRV
HHHHHHCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
YRDIVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQAVLALLE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEECCCCEEEEEEECCCCCHHHHHHHHHH
SPLGQLLYAAGSGTLADFGELRWHDGAAVTVVLAAANYPGRPRVGDVITGSEAEGVLHAG
CCHHHHEEECCCCCHHHHHCEEECCCCEEEEEEEECCCCCCCCCCCEEECCCCCCEEECC
TARREDGEIVSSGGRVLSVVGTGPDLAAARAKAYQILGSIRLPGSHFRTDIAQSAADGKI
CCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
RV
CC
>Mature Secondary Structure
MRVLVIGSGAREHALLLALRKDPQVTGLAIAPGNAGTARLAEQHDVDITSAPDVVALARA
CEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
VRADLVVIGPEVPLVLGVADALRAAGIVCFGPGKDAARIEGSKAFAKEVMAAAGVRTAAS
HHCCEEEECCCCCEEEEHHHHHHHCCEEEECCCCCCCEECCHHHHHHHHHHHHCHHHHHH
EIVDTPAHLDAALDRFGPPAGEAAWVVKDDRLAAGKGVVVTADREVARAHAAALLEAGHP
HHHCCHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCEEEECCHHHHHHHHHHHHHCCCH
VLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDADSGPNTGGMGAYAPVPWLPDRV
HHHHHHCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
YRDIVHRIVEPVAAEMVARGCPFSGLLYAGLAITSNGPAVVEFNCRFGDPETQAVLALLE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEECCCCEEEEEEECCCCCHHHHHHHHHH
SPLGQLLYAAGSGTLADFGELRWHDGAAVTVVLAAANYPGRPRVGDVITGSEAEGVLHAG
CCHHHHEEECCCCCHHHHHCEEECCCCEEEEEEEECCCCCCCCCCCEEECCCCCCEEECC
TARREDGEIVSSGGRVLSVVGTGPDLAAARAKAYQILGSIRLPGSHFRTDIAQSAADGKI
CCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]