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The map label for this gene is phoP

Identifier: 41406689

GI number: 41406689

Start: 617268

End: 617987

Strand: Direct

Name: phoP

Synonym: MAP0591

Alternate gene names: 41406689

Gene position: 617268-617987 (Clockwise)

Preceding gene: 41406688

Following gene: 41406690

Centisome position: 12.78

GC content: 66.11

Gene sequence:

>720_bases
ATGACATCGGCCACCCCCACTGACGCCAAACCGGAGGCTCGCGTTCTCGTCGTCGACGACGAGGCCAACATCGTCGAACT
GCTCTCGGTGAGCCTGAAATTCCAGGGGTTCGAGGTCCACACCGCCACCAACGGCGCCCAAGCCCTGGACCGGGCGCGCG
AGGCCCGTCCCGACGCGGTGATCCTGGACGTGATGATGCCCGGCATGGACGGGTTCGGGGTGCTGCGCCGGCTGCGCGCC
GACGGCATCGACGCGCCCGCGTTGTTCCTGACGGCGCGAGATTCCTTGCAGGACAAGATCGCCGGGCTGACCCTGGGCGG
CGACGACTACGTGACCAAACCGTTCAGCTTGGAAGAGGTGGTCGCCCGGCTGCGGGTCATCCTGCGGCGCGCCGGTAAGG
GCGGGGCCGAACCACGCAGCGCCCGACTGACTTTCGCCGACATCGAACTCGACGAGGAAACCCACGAAGTGTGGAAGGCC
GGTCAACCGGTCTCGCTGTCGCCGAACGAATTCACGCTGCTGCGCTACTTTGTCATCAACGCGGGCACGGTGTTGAGCAA
GCCGAAGATCCTCGACCACGTGTGGCGCTACGACTTCGGAGGTGACGTCAATGTCGTCGAGTCCTACGTGTCGTACCTGC
GCCGCAAGATCGACACCGGCGAGAAGCGGCTGCTGCACACGCTGCGCGGCGTCGGCTATGTGCTGCGGGAACCGCGCTGA

Upstream 100 bases:

>100_bases
ATGATTCCTGGCAGACTACTATCAGTCTGTTGGCACTGAGCTCGCAGGAATCACACAATCTTTCCATAGCAAACGTTCAA
GCAAGGGACACCAGCACCTC

Downstream 100 bases:

>100_bases
GCGCGCGCTCGGCCACCGGCGGTAGCGAGGAATCGGTCAGATGGTGGTGACAAGGCCTCGACGCGGACTACCCCTGCGGG
TGGGGCTGGTCGCCGCCACC

Product: PhoP

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTSATPTDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTATNGAQALDRAREARPDAVILDVMMPGMDGFGVLRRLRA
DGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGGAEPRSARLTFADIELDEETHEVWKA
GQPVSLSPNEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR

Sequences:

>Translated_239_residues
MTSATPTDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTATNGAQALDRAREARPDAVILDVMMPGMDGFGVLRRLRA
DGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGGAEPRSARLTFADIELDEETHEVWKA
GQPVSLSPNEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR
>Mature_238_residues
TSATPTDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTATNGAQALDRAREARPDAVILDVMMPGMDGFGVLRRLRAD
GIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGGAEPRSARLTFADIELDEETHEVWKAG
QPVSLSPNEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=37.6106194690265, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=40.1785714285714, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.0807174887892, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.0535714285714, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=32.8828828828829, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=31.6742081447964, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.0396475770925, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=35.2941176470588, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.7354260089686, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788550, Length=155, Percent_Identity=34.1935483870968, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.3333333333333, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.8793103448276, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=34.2592592592593, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=35.4545454545455, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693157, Length=144, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788191, Length=127, Percent_Identity=34.6456692913386, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=33.6283185840708, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26477; Mature: 26345

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSATPTDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTATNGAQALDRAREARPDAV
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHEECCEEEEECCCHHHHHHHHHHCCCCEE
ILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEV
EEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHH
VARLRVILRRAGKGGAEPRSARLTFADIELDEETHEVWKAGQPVSLSPNEFTLLRYFVIN
HHHHHHHHHHCCCCCCCCCCCEEEEEEEEECHHHHHHHHCCCCCCCCCCCCEEHHHHHHC
AGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSATPTDAKPEARVLVVDDEANIVELLSVSLKFQGFEVHTATNGAQALDRAREARPDAV
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHEECCEEEEECCCHHHHHHHHHHCCCCEE
ILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEV
EEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHH
VARLRVILRRAGKGGAEPRSARLTFADIELDEETHEVWKAGQPVSLSPNEFTLLRYFVIN
HHHHHHHHHHCCCCCCCCCCCEEEEEEEEECHHHHHHHHCCCCCCCCCCCCEEHHHHHHC
AGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA